Cisco Secure Email Threat Defense vs Trellix Collaboration Security comparison

Why PeerSpot?

Cisco and Trellix are both solutions in the Email Security category. Cisco is ranked #23 with an average rating of 7.3, while Trellix is ranked #10 with an average rating of 8.8. Cisco holds a 1.1% mindshare in Email Security, compared to Trellix’s 2.6% mindshare. Additionally, 93% of Cisco users are willing to recommend the solution, compared to 100% of Trellix users who would recommend it.

Cisco Secure Email Threat D...

Read 16 Cisco Secure Email Threat Defense reviews

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2,730 Comparison Views

93% willing to recommend

Trellix Collaboration Security

Read 21 Trellix Collaboration Security reviews

6,238 Views
4,803 Comparison Views

100% willing to recommend

Cisco Secure Email Threat D...

Trellix Collaboration Security

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Executive SummaryUpdated on Dec 3, 2024

Trellix Collaboration Security and Cisco Secure Email Threat Defense compete in the email security domain. Trellix has better feedback on pricing and support, while Cisco leads in feature comprehensiveness.

Features: Trellix offers robust data protection, seamless integration with collaboration tools, and enhanced control over shared content. Cisco provides advanced threat detection, efficient response capabilities, and superior threat intelligence that supports real-time threat mitigation.

Room for Improvement: Trellix could enhance its threat intelligence capabilities, expand on advanced threat detection, and improve scalability. Cisco might benefit from simplifying its deployment process, reducing its initial setup time, and offering more competitive pricing.

Ease of Deployment and Customer Service: Trellix offers a straightforward deployment process and proactive support, appealing to those seeking simplicity. Cisco requires more setup time but is supported by a broad range of resources and strong technical support, making it suitable for enterprises needing extensive assistance.

Pricing and ROI: Trellix generally has a lower initial setup cost and demonstrates quicker ROI, making it a budget-friendly option. Cisco represents a higher upfront investment but offers significant returns through extensive security features and long-term scalability benefits.

To learn more, read our detailed Cisco Secure Email Threat Defense vs. Trellix Collaboration Security Report (Updated: September 2026).

Buyer's Guide

Cisco Secure Email Threat Defense vs. Trellix Collaboration Security

September 2026

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Cisco Secure Email Threat D...

Ranking in Email Security

23rd

Average Rating

8.0

Reviews Sentiment

6.7

Number of Reviews

Ranking in other categories

No ranking in other categories

Trellix Collaboration Security

Ranking in Email Security

10th

Average Rating

8.8

Reviews Sentiment

6.9

Number of Reviews

Ranking in other categories

Instant Communications Security and Compliance (2nd), Secure Email Gateway (SEG) (5th), AI Security (14th)

Mindshare comparison

As of October 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Trellix Collaboration Security is 2.6%, up from 1.7% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Email Security Mindshare Distribution
Product	Mindshare (%)
Trellix Collaboration Security	2.6%
Cisco Secure Email Threat Defense	1.1%
Other	96.3%

Email Security

Featured Reviews

Glenn-Camilien

Senior Cybersecurity Engineer at a financial services firm with 11-50 employees

Provides robust email security features but requires improved modernization and complexity management

Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.

Read full review

Jorge Abalo

Endpoint Security Analyst at BNP Paribas

Endpoint protection has strengthened network control and has simplified global threat response

In my opinion, the best features Trellix Collaboration Security offers include the firewall, the on-access scan, and the ability to obtain daily signatures for the latest malware. These daily signatures, referred to as content, ensure that we are protected against the most recent malware threats recognized by other companies. Another feature I particularly enjoy is the capability to maintain different locations that can communicate with the fabric, or DXL fabric as I refer to it, allowing me to create something akin to an EDR for immediate responses to resolve issues. The DXL fabric has helped my organization by enabling communication between different locations, such as one in Europe, another in South America, and one here. This fabric communicates with a broker that interacts with the TIE servers, which maintain the reputation of files, certificates, and known signatures from various regions including Europe, South America, and Canada. When something suspicious occurs, such as a certificate appearing malicious on an application, I can easily click and indicate that I trust this file, and through the fabric, I can apply an exclusion for that application across all locations simultaneously. Other features I find valuable include the SSO integration with Trellix EPO, specifically SAML SSO, allowing people not to have to manage usernames and passwords if they already utilize an SSO service for SAML; I consider this functionality to be quite beneficial.

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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."

"The solution is stable."

"On ease of use, it rates very high."

"Currently, the ease of deployment is the low-hanging fruit for Cisco email security."

"Cisco Cloud Mailbox is used for copying emails, anti-spamming, and securing the company's email, and we really enjoy the anti-spamming capabilities as well as the rejecting of bulk emails, which we can customize by adjusting the variables, and it is very user-friendly."

"The features and functionalities are much better than Microsoft's in-built Defender plan, and this product has helped us to protect our organization from any malware attack in the past."

"Regarding stability, Cisco Secure Email Threat Defense is very stable."

"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."

More Cisco Secure Email Threat Defense pros

"FireEye ETP has blocked several campaigns that lead to the post compromise deployment of ransomware, Obfuscated Outlook Phishing impersonation, Attachment based Phishing."

"The solution offers almost every feature that customers need in one solution, for example, spam filtering, antivirus, et cetera, with almost zero false positives."

"The accessibility is one of the features that I love; we can control it from the cloud and we can access it from anywhere."

"The solution's most valuable feature is its simplicity. It's very user-friendly."

"The initial setup is simple."

"FireEye Email Security is easy to use."

"Trellix Collaboration Security has positively impacted our organization by making our collaboration environment very safe, allowing our team to share files and links without worrying about threats."

"A specific example of how I have used Trellix Collaboration Security in my consulting work is in my current work environment, where I manage over 130,000 endpoints, allowing me to protect each endpoint with a firewall, which makes a significant difference because the entire network is not protected by a network firewall alone."

More Trellix Collaboration Security pros

Cons

"The pricing could always be better."

"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."

"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."

"We encounter issues while searching for missing emails."

"The search area has room for improvement."

"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."

"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."

"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."

More Cisco Secure Email Threat Defense cons

"Trellix Collaboration Security can be improved by making the reporting and analysis tools more detailed."

"The cloud product is not open to the customers. If the system itself could be more open to the customer, I'd be able to configure it more specifically."

"If you really need something powerful to handle multiple routes and delivery points then this solution might not be for you."

"I chose a nine out of ten because some improvements are required, especially concerning East-West traffic or zero-day vulnerabilities."

"I would like the solution to be able to automatically quarantine the malicious emails before getting to the user's mailbox and continue with regular email operations. This could result in the user clicking the email before the purge operation is completed."

"I would like to see this solution become more flexible."

"The solution is not easy to set up. However, we have employees that have the knowledge that can do the difficult implementation. It would be better if the process was easier."

"If they want to be the primary or best solution, they need to have better email management features."

More Trellix Collaboration Security cons

Pricing and Cost Advice

"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."

"The feedback from vendors and customer is that it is expensive."

"It is expensive compared to other vendors."

"The solution’s pricing is manageable."

"The cost is very high."

"The solution requires a license to be purchased for every user."

"I rate the product price as nine out of ten, where ten is the most expensive, and one is the cheapest. There is no need to pay any extra charges apart from the licensing costs."

"The licensing is on a yearly basis."

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Top Industries

By visitors reading reviews

Marketing Services Firm

11%

Outsourcing Company

Comms Service Provider

Healthcare Company

Construction Company

14%

Healthcare Company

12%

Comms Service Provider

12%

Manufacturing Company

11%

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	4
Midsize Enterprise	6
Large Enterprise	7

By reviewers
Company Size	Count
Small Business	15
Midsize Enterprise	7
Large Enterprise	17

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?

Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.

See all answers

What needs improvement with Secure Email Threat Defense?

We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...

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What is your primary use case for Secure Email Threat Defense?

We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.

See all answers

What needs improvement with FireEye Email Security?

A few areas stand out: Market coverage. The product needs to expand into markets it currently doesn't fully serve — North Africa in particular — and address the sales restrictions that exist in cer...

See all answers

What is your primary use case for FireEye Email Security?

Trellix Collaboration Security is a tool used for file inspection, URL analysis, behavioral analysis, and integration with existing security tools. The product mainly serves the purpose of scanning...

See all answers

What advice do you have for others considering FireEye Email Security?

Trellix Collaboration Security has seamless integration with most vendors, especially the SIEM solutions vendors, which is an advantage. There is, however, room for improvement in support services,...

See all answers

Comparisons

Cisco Secure Email vs Cisco Secure Email Threat Defense

Compared 18% of the time

Check Point Anti-Spam and Email Security Software Blade vs Cisco Secure Email Threat Defense

Compared 17% of the time

Microsoft Defender for Office 365 vs Cisco Secure Email Threat Defense

Compared 15% of the time

Kiteworks vs Cisco Secure Email Threat Defense

Compared 11% of the time

Comodo Secure Email Gateway vs Cisco Secure Email Threat Defense

Compared 8% of the time

More Cisco Secure Email Threat Defense Competitors

Cisco Secure Email vs Trellix Collaboration Security

Compared 62% of the time

Mimecast Advanced Email Security vs Trellix Collaboration Security

Compared 4% of the time

MetaDefender Email Security Solutions vs Trellix Collaboration Security

Compared 4% of the time

Microsoft Defender for Office 365 vs Trellix Collaboration Security

Compared 3% of the time

Barracuda Email Security Gateway vs Trellix Collaboration Security

Compared 3% of the time

More Trellix Collaboration Security Competitors

Product Reports

Buyer's Guide

Cisco Secure Email Threat Defense

October 2026

Cisco Secure Email Threat Defense report

Download Cisco Secure Email Threat Defense product report

Buyer's Guide

Trellix Collaboration Security

September 2026

Download Trellix Collaboration Security product report

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense

FireEye Email Security

Overview

Cisco Secure Email Threat Defense offers robust email security with features like east-west traffic visibility and seamless SaaS deployment. It enhances cloud email protection by integrating Threat Grid sandboxing and AMP for malware defense, supported by Cisco Talos threat intelligence.

Enhancing email security for Microsoft 365 and cloud emails, Cisco Secure Email Threat Defense acts as an email gateway, blocking phishing, malware, and business email compromise. Users benefit from a centralized management console, efficient graymail administration, and strong filtering capabilities. Despite its strengths, it requires improvements in integration, spam detection accuracy, and enhances phishing protection.

What are the most important features of Cisco Secure Email Threat Defense?

East-West Traffic Visibility: Offers insight into email tenant interactions.
SaaS Application Deployment: Simplifies deployment processes.
Threat Grid Sandboxing: Provides advanced malware protection.
AMP Integration: Enhances malware defense capabilities.
Anti-Spam and Antivirus: Powered by Cisco Talos threat intelligence.
Cloud Mailbox Features: Includes robust email filtering and management.

What benefits or ROI should be evaluated in reviews?

Enhanced Security: Provides protection against advanced threats.
Operational Efficiency: Reduces reliance on help desk services.
User-Friendly Management: Streamlines email administration tasks.
Improved Email Filtering: Ensures effective threat blocking.

Cisco Secure Email Threat Defense is highly applicable in industries requiring stringent data protection, such as finance and healthcare. It serves cloud-based environments by closely monitoring email activity to prevent unauthorized access and breaches. Tailored deployment options cater to both on-premise and cloud architectures, allowing flexible integration in existing workflows.

Cisco

Trellix Collaboration Security enhances communication platforms with robust protective measures, utilizing threat intelligence, secure file sharing, customizable dashboards, and cloud compatibility. Its design fosters real-time threat prevention with features like deep packet inspection and automatic mail scans.

Established to secure communications, Trellix Collaboration Security employs advanced technologies like GTI threat intelligence and SSL to ensure data safety. Users benefit from real-time threat detection, streamlined cloud integration, and a responsive interface. Its functionalities include automatic email scanning, firewall and anti-spam capabilities that build a reliable security infrastructure revered for its scalability and straightforward deployment. Trellix also integrates threat intelligence tools and enhances control over security operations, encouraging efficient prevention strategies.

What are the essential features of Trellix Collaboration Security?

GTI Threat Intelligence: Provides insights into potential threats.
Deep Packet Inspection: Examines data packets to detect malicious activities.
Secure File Sharing: Facilitates secure exchanging of files.
Customizable Dashboards: Offers adaptable views for tailored monitoring.
Automatic Mail Scans: Identifies and filters threats in emails.

Which benefits and ROI should be considered?

Real-Time Threat Response: Ensures immediate action against detected threats.
Cloud Platform Compatibility: Supports hybrid environments for flexible operations.
Scalability: Adapts to the growing security needs without compromising efficiency.
User-Friendly Interface: Enhances user interaction and ease of use.

In distinct industries like finance and healthcare, Trellix Collaboration Security plays a crucial role in ensuring email protection and secure data exchange. It helps these sectors combat threats like phishing and unauthorized access by leveraging advanced scanning methods and integrating management tools such as LDAP. Organizations value its ability to safeguard network communications and manage large-scale endpoints effectively, whether on-premise or in the cloud. The solution's customization and configuration capabilities allow tailored implementations, ensuring optimal protection across diverse operational needs.

Trellix

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom

Northshore Utility District, Luz Technologies, Air Academy Federal Credit Union, Bank Gutmann, Bank of Thailand, Penn State Health Milton S. Hershey Medical Center, State of Missouri, City and County of San Francisco, Denver Public Schools, Vodafone, Go Auto, Stater Bros. Market

Buyer's Guide

Cisco Secure Email Threat Defense vs. Trellix Collaboration Security

September 2026

Free Report: Cisco Secure Email Threat Defense vs. Trellix Collaboration Security

Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Trellix Collaboration Security and other solutions. Updated: September 2026.

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