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Cisco Secure Email Threat Defense vs Trellix Collaboration Security comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
20th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Trellix Collaboration Security
Ranking in Email Security
18th
Average Rating
8.6
Reviews Sentiment
7.0
Number of Reviews
15
Ranking in other categories
Instant Communications Security and Compliance (7th), Secure Email Gateway (SEG) (9th)
 

Mindshare comparison

As of June 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.6%, down from 17.6% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Trellix Collaboration Security is 2.0%, down from 2.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
BernardLugalia - PeerSpot reviewer
Provides strong data protection with virtual patching and vulnerability assessments
I primarily use it to monitor database access, particularly in banking and similar environments. It ensures that IT personnel and others do not create unauthorized accounts or users. Collaboration security assists in tracking database access and alerts in case of suspicious activity One of the…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Microsoft Defender for Office 365's most valuable feature is its performance."
"The DLP feature of Microsoft Defender for Office 365 is valuable, and we also use the DLP feature for email real-time detection."
"The deployment capability is a great feature."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"Microsoft Defender for Office 365 is a stable solution."
"We use Microsoft Defender for its ability to integrate with existing business technologies, which is beneficial for protecting business areas."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"It's very easy to deploy and configure."
"The product offers protection, email security, anti-spam, and antivirus."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"The solution is stable."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"Before installing, consider potential challenges with system performance, especially when integrating multiple tools, which could slow down performance."
"The product helps reduce the number of malicious emails reaching the user's inbox."
"FireEye Email Security is easy to use."
"FireEye Email Security helps us prevent spam and phishing emails and all other business-compromised email attacks."
"One of the valuable features of the product stems from the fact that it is easy to implement the tool in our environment."
"Trellix Collaboration Security is valued for being a stable and comprehensive solution that fulfills customer needs."
"We can control this solution from the cloud and are able to access it from wherever we are."
"The initial setup is simple."
 

Cons

"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"Microsoft security solutions work as expected. They are constantly updating the solutions to make them better. At the same time, the changes can impact a customer's environment, and we need to adjust settings. Sometimes we aren't aware of the changes, and nothing is pushed from the backend automatically."
"There's room for improvement regarding the time frame for retrieving emails."
"We need to be able to whitelist data at the backend."
"Configuration requires going to a lot of places rather than just accessing one tab."
"The product must provide better malware detection."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The solution is a bit expensive."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"We encounter issues while searching for missing emails."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"The solution needs better support."
"Sometimes, integration can be challenging, impacting its stability, which is why I rate it a five out of ten."
"The solution is not easy to set up. However, we have employees that have the knowledge that can do the difficult implementation. It would be better if the process was easier."
"FireEye needs single sign-on. They say it's on their roadmap. They should also implement support for Microsoft Authenticator app for 2FA."
"The solution must provide features to scan QR codes for threats."
"In general, our company should make the tool more robust to protect our systems."
"The reporting aspect of the solution needs improvement."
"I would like to see this solution become more flexible."
 

Pricing and Cost Advice

"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"The pricing has become expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"The cost is very high."
"The licensing is on a yearly basis."
"The solution requires a license to be purchased for every user."
"I rate the product price as nine out of ten, where ten is the most expensive, and one is the cheapest. There is no need to pay any extra charges apart from the licensing costs."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
30%
Government
7%
Healthcare Company
7%
Financial Services Firm
5%
Manufacturing Company
16%
Computer Software Company
14%
Financial Services Firm
9%
Government
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The physical appliance has been discontinued, although the platform still exists. Improvements here and there could b...
What do you like most about FireEye Email Security?
One of the valuable features of the product stems from the fact that it is easy to implement the tool in our environm...
What needs improvement with FireEye Email Security?
I would like to see the addition of email digital protection features, such as anti-spam and antivirus, not just sand...
What is your primary use case for FireEye Email Security?
I have worked on Email Security ( /categories/email-security ) both on-premises and in the cloud, Web Security, and a...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
FireEye Email Security
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Northshore Utility District, Luz Technologies, Air Academy Federal Credit Union, Bank Gutmann, Bank of Thailand, Penn State Health Milton S. Hershey Medical Center, State of Missouri, City and County of San Francisco, Denver Public Schools, Vodafone, Go Auto, Stater Bros. Market
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Trellix Collaboration Security and other solutions. Updated: June 2025.
856,874 professionals have used our research since 2012.