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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
20th
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (12th), Data Loss Prevention (DLP) (21st), Cloud Access Security Brokers (CASB) (13th), Distributed Denial-of-Service (DDoS) Protection (8th), Software Defined WAN (SD-WAN) Solutions (12th), Access Management (11th), Bot Management (3rd), ZTNA as a Service (9th), ZTNA (4th), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email Threat D...
Ranking in Email Security
19th
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of June 2026, in the Email Security category, the mindshare of Cloudflare One is 1.6%, up from 1.6% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 6.3%, down from 12.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3656.3%
Cisco Secure Email Threat Defense1.1%
Cloudflare One1.6%
Other91.0%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Using Cloudflare One makes my work quite easy because for DDoS protection, all I need to do is understand the OSI model and click; it makes it easier than trying to write a command line or use a Linux command."
"The capabilities of the software are strong enough for me to do what it's supposed to do. For me, we don't need to do a lot of configuration on our site. We just enable it and monitor it."
"It's the endpoint exposition. We don't need to expose our VPN server to the internet and need a zero-test solution. I can apply some conditional access to the endpoint that's connecting to our network to check their security policies or the security condition of their workstation. Once the workstation is trying to connect to my internal network, then I would like to check the discrete condition of these endpoints that are trying to access my internal network. We created some conditional access. We have CrowdStrike, to check if the CrowdStrike is installed, to check if it's updated, and to check for Windows updates. We created some conditional policies to check it."
"It's a perfect solution from my perspective; it's easy to understand and easy to configure."
"Cloudflare, in my opinion, was easy to implement."
"Clover is the best product globally."
"The simplicity of the solution is its valuable features as almost no effort was needed to learn the configurations. It is also one of the cheapest firewalls available in this category."
"Cloudflare One has assisted in securing my remote workforce through a SASE solution with Cloudflare One and the Workers part, although I am not currently using the Workers component."
"On ease of use, it rates very high. It's something that I was able to get into without really looking at any documentation. I wanted to see what it felt like before I started looking at any documentation on how to use it, and it was very easy to use. It works very smoothly. The user experience is very intuitive. They did an amazing job on that."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"On ease of use, it rates very high."
"It's very easy to deploy and configure."
"I highly recommend it as one of the best choices."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The coolest feature of Microsoft Defender for Office 365 is its ability to look for phishing emails."
"Technical support is very good. They are knowledgeable and respond quickly."
"I would say that 90% of the spam and phishing attack emails get blocked right off the bat."
"Microsoft Defender for Office 365 is a stable solution."
"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."
"Microsoft Defender for Office 365 facilitates efficient management and updates through the cloud. We do not have to worry about incompatibilities. It just works."
"Defender enables us to secure all 365-related activity from a single place. It gives us visibility into everything happening in Outlook, protecting us against phishing and other email-based threats. Defender helps us detect any suspicious behaviors."
 

Cons

"I would like them to include a VPN feature to provide a secure connection to the data center."
"Feedback could be enhanced. While I work efficiently with Clover as a partner in Mexico City, sometimes the information and requests are easier to manage with more concrete solutions."
"The pricing is an area that can be improved. Pricing, as far as I recall, was the source of our problems."
"Cloudflare One is not very powerful, but for what we require, it is basic and sufficient."
"Our subscription plan for the solution has a limitation of bot signatures."
"From a logging perspective, it is still a bit difficult to see exactly what users are being blocked with the current views."
"The tool should provide on-premise versions. Currently, all versions are cloud-based."
"They don't have a person to provide support for customers using the solution under their free plan."
"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"I wouldn't recommend Cisco to others because I think Fortinet is better."
"We encounter issues while searching for missing emails."
"The solution is a bit expensive. It could be cheaper."
"The search area has room for improvement."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"This solution could be improved by integration with Sandbox."
"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."
"Microsoft sometimes has downtime, and we'll get several incidents coming in back to back. We have a huge backlog of notifications, many of which may be false positives. However, there might be serious alerts, so we can't risk dismissing all of them at once."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"Microsoft wants its well-paying customers to finish testing some of its half-baked products, find bugs, and report bugs back to Microsoft's team, which is a little frustrating for those who have to manage it and roll it up to thousands of people across the organization."
"The product must provide better malware detection."
"This is quite an expensive solution and understanding the pricing model and features is quite complicated and it can, in fact, be a nightmare when dealing with Microsoft."
"I think that Microsoft Defender for Office 365 could be improved if it could use VirusTotal to compare the programs or anything that I download."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
 

Pricing and Cost Advice

"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"The solution is not that expensive."
"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"The prices are slightly expensive."
"Cloudflare Zero Trust Platform's pricing is good."
"The solution's pricing lacks transparency."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"The pricing has become expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
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Top Industries

By visitors reading reviews
Construction Company
19%
Comms Service Provider
10%
Financial Services Firm
9%
Manufacturing Company
8%
Marketing Services Firm
12%
Manufacturing Company
8%
Computer Software Company
7%
Government
7%
Computer Software Company
12%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise1
Large Enterprise12
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What needs improvement with Cloudflare Zero Trust Platform?
In my opinion, Cloudflare One can be improved mainly through compatibility, as the integration should be much simpler...
What is your primary use case for Cloudflare Zero Trust Platform?
Cloudflare One's primary use case for my organization is to protect servers and to provide remote access with the VPN...
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, ...
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new ...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat De...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Defender for Office 365 and other solutions. Updated: June 2026.
900,838 professionals have used our research since 2012.