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Palo Alto Networks VM-Series vs ThreatLocker Zero Trust Endpoint Protection Platform comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Oct 5, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
5.7
Palo Alto Networks VM-Series delivers strong ROI through enhanced security, rapid deployment, and significant time savings despite high pricing.
Sentiment score
7.9
ThreatLocker Zero Trust boosts ROI by blocking threats, reducing risks, and enhancing security with seamless integration and quick adaptation.
Customers can see data within a week, indicating a quick return on investment.
Senior Manager Technical Security at Hitachi Systems, Ltd.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
Tier 1 IT Engineer at a retailer with 11-50 employees
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
Project Engineer at Lutz M&A, LLC
It keeps malware, Trojans, and ransomware at bay.
Technical Engineer at Cloud 1 Solutions
 

Customer Service

Sentiment score
7.5
Customers appreciate Palo Alto Networks VM-Series support for responsiveness and expertise, despite occasional delays and high premium service costs.
Sentiment score
7.7
ThreatLocker offers exceptional 24/7 customer service with fast issue resolution, highly rated by users for speed and expertise.
The support quality could be improved.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Resolving issues promptly.
Head of Sales at Omgea Exim Ltd
They are responsive and provide high-quality assistance.
Cyber security consultant at L&T Technology Services
They have been very responsive, helpful, and knowledgeable.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate their customer support a ten out of ten.
Director, Managed Services at a consultancy with 11-50 employees
Their support is world-class.
Supervisor, Client Security at a consultancy with 11-50 employees
 

Scalability Issues

Sentiment score
7.4
Palo Alto Networks VM-Series is scalable, easy to deploy, and suits businesses with positive feedback on flexibility and growth.
Sentiment score
8.0
ThreatLocker scales efficiently, handling thousands of endpoints easily, with updates and flexible deployment supporting diverse organizational needs.
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
Security Technical Lead at a tech services company with 11-50 employees
The solution is scalable and can easily handle an increase in the number of users.
Cyber security consultant at L&T Technology Services
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
Senior Security Consultant at Netsecurity.no
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
Technical Engineer at Cloud 1 Solutions
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate it a ten out of ten for scalability.
Project Engineer at Lutz M&A, LLC
 

Stability Issues

Sentiment score
8.2
Palo Alto Networks VM-Series is highly regarded for stability, reliable performance, and consistent uptime, despite minor navigation delays.
Sentiment score
7.4
ThreatLocker Zero Trust Platform offers stable performance, minimal downtime, quick issue resolution, and seamless integration with operating systems.
Hardware is generally very stable.
Security Technical Lead at a tech services company with 11-50 employees
I have not experienced any major problems or downtime.
Senior IT Infrastructure Specialist at contemi
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
Senior Security Consultant at Netsecurity.no
For five years, we have not had a problem.
Supervisor, Client Security at a consultancy with 11-50 employees
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
Information Cybersecurity Technology Specialist at Freez.it
It has been very stable, reliable, and accessible.
COO at Panda Technology
 

Room For Improvement

Palo Alto Networks VM-Series needs UI updates, better platform integration, scalability, user-friendliness, and improved documentation for broader efficiency.
ThreatLocker could improve by enhancing training, UI, reporting, integration, and support to address approval and update challenges.
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Cyber security consultant at L&T Technology Services
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
Security Technical Lead at a tech services company with 11-50 employees
Having those features missing, we are not proposing Palo Alto Networks VM-Series to all customers.
Sr. Network Engineer at a tech services company with 1-10 employees
Controlling the cloud environment, not just endpoints, is crucial.
COO at Panda Technology
This is problematic when immediate attention is needed.
Senior System Administrator at Molders Group Limited
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
IMS ENGINEER at a tech vendor with 1,001-5,000 employees
 

Setup Cost

Palo Alto VM-Series is costly but reliable, with complex licensing; AWS Marketplace offers scalable subscription options.
ThreatLocker offers a cost-effective Zero Trust solution with flexible pricing, appreciated for transparency and easy setup across clients.
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
Security Technical Lead at a tech services company with 11-50 employees
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Senior IT Infrastructure Specialist at contemi
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
Head of Sales at Omgea Exim Ltd
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
Director, Managed Services at a consultancy with 11-50 employees
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
Supervisor, Client Security at a consultancy with 11-50 employees
I had a really good deal at the time, and it continues to be cost-effective.
Cyber Security Specialist at Bremmar Consulting
 

Valuable Features

The VM-Series provides scalable, flexible security with advanced threat management, visibility, and integration features, enhancing network protection.
ThreatLocker enhances security and reduces costs with application control, instant support, intuitive interface, and comprehensive training resources.
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
Security Technical Lead at a tech services company with 11-50 employees
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
Senior Security Consultant at Netsecurity.no
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
Cyber Security Specialist at Bremmar Consulting
It protects our customers.
CTO at Zettabytes
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
Tier 1 IT Engineer at a retailer with 11-50 employees
 

Categories and Ranking

Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
11th
Average Rating
8.6
Reviews Sentiment
6.9
Number of Reviews
66
Ranking in other categories
Firewalls (13th)
ThreatLocker Zero Trust End...
Ranking in Advanced Threat Protection (ATP)
6th
Average Rating
9.2
Reviews Sentiment
7.4
Number of Reviews
40
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
 

Mindshare comparison

As of January 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Palo Alto Networks VM-Series is 2.3%, up from 1.1% compared to the previous year. The mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 2.7%, up from 1.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
ThreatLocker Zero Trust Endpoint Protection Platform2.7%
Palo Alto Networks VM-Series2.3%
Other95.0%
Advanced Threat Protection (ATP)
 

Featured Reviews

AV
Cyber security consultant at L&T Technology Services
Enhance cybersecurity for large enterprises using advanced threat management
An improvement could be the integration of security intelligence with Palo Alto cloud via APIs. This would allow IOCs, domains, and hash values to be automatically entered, reducing manual entry. Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
CL
Supervisor, Client Security at a consultancy with 11-50 employees
World-class support and highly effective for application control and elevation
Their product is solid. I have a hard time complaining much about it because when we do find little things, they are usually interface-related or related to things that would be nice to have. Their idea portal, unlike so many other vendors we deal with, shows movement. At least four to eight features of ThreatLocker exist because I made a request in the last five years, and it became a feature of the actual product. When it comes to improvements, we moved the product as customers, and we got to move the product by making suggestions. They seem to be very reactive to it, so there is not a whole lot that they actively need to change right now. It is one of those situations where when we run into something that would be nice to have, it happens. They make it work.
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Use our free recommendation engine to learn which Advanced Threat Protection (ATP) solutions are best for your needs.
879,422 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
12%
Manufacturing Company
10%
Financial Services Firm
10%
University
6%
Computer Software Company
25%
Retailer
8%
Manufacturing Company
8%
Financial Services Firm
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business29
Midsize Enterprise17
Large Enterprise24
By reviewers
Company SizeCount
Small Business32
Midsize Enterprise4
Large Enterprise3
 

Questions from the Community

Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
Going with the theme of ThreatLocker Zero Trust Endpoint Protection Platform being a one-stop shop where they have just about everything, and they have a really good product stack as is. However, t...
 

Also Known As

No data available
Protect, Allowlisting, Network Control, Ringfencing
 

Overview

 

Sample Customers

Warren Rogers Associates
Information Not Available
Find out what your peers are saying about Palo Alto Networks VM-Series vs. ThreatLocker Zero Trust Endpoint Protection Platform and other solutions. Updated: December 2025.
879,422 professionals have used our research since 2012.