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ThreatLocker Zero Trust Platform vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Mar 17, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

ThreatLocker Zero Trust Pla...
Ranking in Advanced Threat Protection (ATP)
4th
Average Rating
9.2
Reviews Sentiment
7.1
Number of Reviews
82
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (5th), Application Control (1st), ZTNA as a Service (5th), ZTNA (5th), Ransomware Protection (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
22nd
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of August 2026, in the Advanced Threat Protection (ATP) category, the mindshare of ThreatLocker Zero Trust Platform is 2.7%, up from 2.3% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 1.9%, up from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
ThreatLocker Zero Trust Platform2.7%
Trellix Advanced Threat Defense1.9%
Other95.4%
Advanced Threat Protection (ATP)
 

Featured Reviews

Santo Joy - PeerSpot reviewer
Head Of Cyber Security at a outsourcing company with 201-500 employees
Security controls have been strengthened with granular application, ringfencing, and access policies
The features of ThreatLocker Zero Trust Endpoint Protection Platform that I like the most are the Ringfencing, elevation control, storage control, and application whitelisting functionality. For examples of how these features benefit my company, we were looking for a solution across various vendors to actually implement application whitelisting controls. ThreatLocker's agent, which is very lightweight and does not use much CPU or RAM, helped us achieve that solution. Ringfencing was an add-on that ticked off a lot of Australian framework security controls, which is the reason we chose it. My impression of the allowlisting feature in terms of managing which software, scripts, and libraries run on my devices is that ThreatLocker's community page has a lot of information around this, which is very helpful. Not only that, the Cyber Hero support that ThreatLocker provides gives us insights and best practices, helping us achieve that solution and guiding us to the right platform. The impact of Ringfencing on controlling the behavior of approved applications has been a big winner for us because it is something that many other platforms do not provide as a functionality. Having that allowed us to identify what applications talk to each other, which is something that many other platforms do not do. The network control feature impacts my ability to manage network traffic across my endpoints and servers. We have not used this widely across all our partners, but wherever required, we use it. It has been an easy solution for those customers to get that control implemented. The elevation feature's role in facilitating just-in-time administrative access for approved applications shows that elevation control helps in many use cases involving remote control platforms, door usage, and security system platforms that require local admins. There are many solutions that provide this functionality, but the licensing cost seems to be expensive, and it also adds another solution into the mix. Rather than doing that, we try to use ThreatLocker Zero Trust Endpoint Protection Platform to achieve that control. Regarding the storage control feature, I have used it. The primary function is USB blocking, which is very widely adopted, and also just locking down and allowing certain users to access certain file locations helps us there. When it comes to enforcing policy-driven access over various storage devices, it depends on the business risk adapted by the companies that we support, but generally the use case is USB and external storage devices where companies know that is a risk, but they do not have appropriate solutions. There are EDR platforms that claim to do this, but ThreatLocker Zero Trust Endpoint Protection Platform does it at an advanced level. My assessment of the efficiency of the real-time threat intelligence and category controls employed by Web Control in blocking malicious and non-compliant sites leads me to think that Web Control is another functionality within ThreatLocker Zero Trust Endpoint Protection Platform that is an add-on on top of the current set. That is another solution that we use based on what is required for the company, but again, that is not widely adapted yet for our partners.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Our assessment of Elevation Control's role in facilitating Just-In-Time administrative access for approved applications is that we are loving it so far."
"Zero-Touch is the future, and ThreatLocker Zero Trust Endpoint Protection Platform is the easiest way to accomplish that."
"The solution has made knowing and managing what is running on our clients' devices much easier for us. We know they cannot run what they are not supposed to run."
"We use ThreatLocker's Allowlisting to whitelist specific applications and prevent unauthorized software from running."
"ThreatLocker Zero Trust Endpoint Protection Platform has helped reduce the incidents of clients getting exploits or ransomware put on their devices by 110 times."
"From one to ten, I would probably rate ThreatLocker Zero Trust Endpoint Protection Platform overall a nine."
"The benefits of using ThreatLocker Zero Trust Endpoint Protection Platform for my company include removing previous tools that we did not prefer, replacing them with this solution, and enjoying a significantly better user experience."
"For companies that are considering ThreatLocker Zero Trust Endpoint Protection Platform, my advice would be to go for it, as it truly changes how you secure your clients and offers more opportunities to provide services to clients that were not feasible before."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."
"I recommend this solution because of its ease of use."
"It is stable and reliable."
"The features I find most valuable are: the management, the ability for automatic remediation of threats and it can successfully detect a threat, and to act upon it."
"The product is expensive, but it is better than the rest of them in the industry."
"Provides good exfiltration, and is an all-in-one product."
"I see ROI, as it stops in excess of twenty-five malware events per month, all of which could be critical to the business."
 

Cons

"ThreatLocker Zero Trust Endpoint Protection Platform can be improved by making the installation easier."
"It's very annoying to uninstall. You have to go into the online control panel and disable tampering for a device before it'll let you uninstall it without complaining really loudly."
"I find that the learning mode is too accessible. Technicians sometimes default to it instead of manually building policy controls. I would prefer the learning mode to be harder to access, ideally hidden behind a layer that requires creating at least one policy first before using the learning mode as a supplement."
"It would be beneficial if it became more recognized in the EU to gain respect."
"One of the things I would really like is the ability to create custom groups and assign machines to them."
"ThreatLocker Zero Trust Endpoint Protection Platform could be improved by being able to consolidate even more with an EDR for deeper scanning as needed."
"The snapshots used in the ThreatLocker University portal are outdated snippets and have not been updated in conjunction with the portal itself."
"From one to ten, I would rate the solution overall as a nine out of ten just because the initial setup was a little confusing."
"Some of our customers have mentioned the lack of a tool that would allow for remote capabilities without being attached to the internet."
"Lacks remote capabilities not dependent on the internet."
"The support on their side is not readily available. It takes a while."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"This solution needs to be made "cloud ready"."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
 

Pricing and Cost Advice

"I do not know about the licensing and price as it comes bundled from our MSP. However, it seems fairly reasonable for us, which is why we chose it."
"Considering what this product does, ThreatLocker is very well-priced, if not too nicely priced for the customer."
"We have not had any real issues with the pricing. As they have added more features, due to the way our contracts are structured with our customers, we have had to hold off on adopting the new features because they do add costs."
"The price of ThreatLocker Allowlisting is reasonable in the market, but it is not fantastic."
"Others say ThreatLocker is too expensive, and I tell them they're dreaming. It's well-priced for what it does."
"The pricing works fine for me. It's very reasonably priced."
"I can't complain. Cheaper would always be nice, but I think it's reasonable compared to other software in the cybersecurity market."
"Its price is fair. They have added some additional things to it beyond allowlisting. They are up-charging for them, but in terms of the value we get and the way it impacts us, we get a bang for our buck with ThreatLocker than a lot of our other security tools."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Computer Software Company
11%
Financial Services Firm
11%
Manufacturing Company
11%
Comms Service Provider
7%
Construction Company
17%
Financial Services Firm
12%
Comms Service Provider
10%
Outsourcing Company
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business56
Midsize Enterprise14
Large Enterprise13
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
My experience with pricing, setup cost, and licensing for ThreatLocker Zero Trust Platform is that the pricing is reasonable, the cost is fair, and the licensing is not too high.
What needs improvement with ThreatLocker Allowlisting?
I would suggest adding an AI-based policy recommendation feature to ThreatLocker Zero Trust Platform because we have to create every policy manually. If there were a custom AI that could help with ...
What is your primary use case for ThreatLocker Allowlisting?
Our main use case for ThreatLocker Zero Trust Platform is to provide endpoint security and to control each and every application end-to-end that can run on the company's devices, primarily to secur...
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
What advice do you have for others considering McAfee Advanced Threat Defense?
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it'...
 

Also Known As

Protect, Allowlisting, Network Control, Ringfencing
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Information Not Available
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about ThreatLocker Zero Trust Platform vs. Trellix Advanced Threat Defense and other solutions. Updated: August 2026.
909,725 professionals have used our research since 2012.