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ThreatLocker Zero Trust Platform vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Mar 17, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

ThreatLocker Zero Trust Pla...
Ranking in Advanced Threat Protection (ATP)
7th
Average Rating
9.2
Reviews Sentiment
7.1
Number of Reviews
74
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
22nd
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of March 2026, in the Advanced Threat Protection (ATP) category, the mindshare of ThreatLocker Zero Trust Platform is 2.6%, up from 2.0% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.1%, up from 1.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
ThreatLocker Zero Trust Endpoint Protection Platform2.6%
Trellix Advanced Threat Defense2.1%
Other95.3%
Advanced Threat Protection (ATP)
 

Featured Reviews

Santo Joy - PeerSpot reviewer
Head Of Cyber Security at a outsourcing company with 201-500 employees
Security controls have been strengthened with granular application, ringfencing, and access policies
The features of ThreatLocker Zero Trust Endpoint Protection Platform that I like the most are the Ringfencing, elevation control, storage control, and application whitelisting functionality. For examples of how these features benefit my company, we were looking for a solution across various vendors to actually implement application whitelisting controls. ThreatLocker's agent, which is very lightweight and does not use much CPU or RAM, helped us achieve that solution. Ringfencing was an add-on that ticked off a lot of Australian framework security controls, which is the reason we chose it. My impression of the allowlisting feature in terms of managing which software, scripts, and libraries run on my devices is that ThreatLocker's community page has a lot of information around this, which is very helpful. Not only that, the Cyber Hero support that ThreatLocker provides gives us insights and best practices, helping us achieve that solution and guiding us to the right platform. The impact of Ringfencing on controlling the behavior of approved applications has been a big winner for us because it is something that many other platforms do not provide as a functionality. Having that allowed us to identify what applications talk to each other, which is something that many other platforms do not do. The network control feature impacts my ability to manage network traffic across my endpoints and servers. We have not used this widely across all our partners, but wherever required, we use it. It has been an easy solution for those customers to get that control implemented. The elevation feature's role in facilitating just-in-time administrative access for approved applications shows that elevation control helps in many use cases involving remote control platforms, door usage, and security system platforms that require local admins. There are many solutions that provide this functionality, but the licensing cost seems to be expensive, and it also adds another solution into the mix. Rather than doing that, we try to use ThreatLocker Zero Trust Endpoint Protection Platform to achieve that control. Regarding the storage control feature, I have used it. The primary function is USB blocking, which is very widely adopted, and also just locking down and allowing certain users to access certain file locations helps us there. When it comes to enforcing policy-driven access over various storage devices, it depends on the business risk adapted by the companies that we support, but generally the use case is USB and external storage devices where companies know that is a risk, but they do not have appropriate solutions. There are EDR platforms that claim to do this, but ThreatLocker Zero Trust Endpoint Protection Platform does it at an advanced level. My assessment of the efficiency of the real-time threat intelligence and category controls employed by Web Control in blocking malicious and non-compliant sites leads me to think that Web Control is another functionality within ThreatLocker Zero Trust Endpoint Protection Platform that is an add-on on top of the current set. That is another solution that we use based on what is required for the company, but again, that is not widely adapted yet for our partners.
PP
RSSI at SDIS49
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent."
"The biggest one that we focus on is the application control with ringfencing. That combination is very beneficial."
"Overall, I would rate ThreatLocker Zero Trust Endpoint Protection Platform a ten out of ten."
"The most valuable feature is probably the ability to block programs from running. ThreatLocker has some built-in features that make it super easy. You can also contact their support within the program. If you're having issues, you can click on that button and connect with someone in five to 10 seconds."
"Application control, ring-fencing, and storage control are the most important features, followed closely by elevation."
"While it can be frustrating at times, we appreciate the low-level security provided by the application whitelist."
"ThreatLocker Zero Trust Endpoint Protection Platform provides no-sweat security that we can easily deploy. We do not worry about our habitual clickers because we receive an alert if they try to do something, and we know ThreatLocker has already taken care of it."
"ThreatLocker Allowlisting has all of these features integrated into one console, making it effective."
"I recommend this solution because of its ease of use."
"The most valuable features are the administration console and its detection and response module."
"It is stable and reliable."
"Provides good exfiltration, and is an all-in-one product."
"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."
"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."
"The features I find most valuable are: the management, the ability for automatic remediation of threats and it can successfully detect a threat, and to act upon it."
"It is very scalable."
 

Cons

"A valuable addition to ThreatLocker would be a column in the audit page displaying a VirusTotal score for each file."
"We have had a few instances where the local database gets corrupted and starts blocking random Windows DLLs, and the support team has always been very quick at helping us identify and remediate that."
"I have encountered some problems with stability, however, they are resolved quickly."
"ThreatLocker Zero Trust Endpoint Protection Platform could be improved by addressing the human identity piece, whether through ThreatLocker Zero Trust Endpoint Protection Platform or another tool."
"To become the best solution, some sort of integration or remote management, like remotely connecting, could be beneficial."
"The reporting could be improved."
"Sometimes it does block new things we try to run, but once we get them approved, it works perfectly and successfully blocks the things we want to be hindered."
"The biggest thing I would like to see improved in ThreatLocker Zero Trust Endpoint Protection Platform is reporting."
"We'd like them to be better at dealing with script threats."
"Some of our customers have mentioned the lack of a tool that would allow for remote capabilities without being attached to the internet."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
"This product does the job, but it is not flexible enough to do new environments yet."
"This solution needs to be made "cloud ready"."
"We'd like them to be better at dealing with script threats."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
 

Pricing and Cost Advice

"The pricing works fine for me. It's very reasonably priced."
"Considering what this product does, ThreatLocker is very well-priced, if not too nicely priced for the customer."
"I can't complain. Cheaper would always be nice, but I think it's reasonable compared to other software in the cybersecurity market."
"I find ThreatLocker's pricing to be reasonable for the services it provides."
"I do not deal with pricing, but I assume it is cost-effective for us. We choose a solution based on functionality and affordability."
"I believe ThreatLocker's pricing model is fair and flexible, allowing account managers to offer customized deals based on our specific needs."
"We have encountered a few challenges regarding pricing, contract renewals, and additions. As we explored adding features like Cyber Hero, it proved to be an increased expense for our clients. This was primarily a mistake on our part due to how we initially priced it to clients."
"Others say ThreatLocker is too expensive, and I tell them they're dreaming. It's well-priced for what it does."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Computer Software Company
17%
Manufacturing Company
8%
Retailer
8%
Financial Services Firm
7%
Construction Company
17%
Comms Service Provider
12%
Outsourcing Company
10%
Performing Arts
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business51
Midsize Enterprise13
Large Enterprise8
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
My experience with pricing, setup cost, and licensing for ThreatLocker Zero Trust Endpoint Protection Platform is good because it has a nominal price.I would say ThreatLocker Zero Trust Endpoint Pr...
What needs improvement with ThreatLocker Allowlisting?
ThreatLocker Zero Trust Endpoint Protection Platform can be improved by providing admin rights that allow us to manage it from the server by providing some token IDs or any kind of OTP if someone h...
What is your primary use case for ThreatLocker Allowlisting?
My main use case for ThreatLocker Zero Trust Endpoint Protection Platform is to secure the server.A specific example of how I use ThreatLocker Zero Trust Endpoint Protection Platform to secure my s...
What do you like most about McAfee Advanced Threat Defense?
I recommend this solution because of its ease of use.
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
 

Also Known As

Protect, Allowlisting, Network Control, Ringfencing
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Information Not Available
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about ThreatLocker Zero Trust Platform vs. Trellix Advanced Threat Defense and other solutions. Updated: March 2026.
885,311 professionals have used our research since 2012.