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Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
21st
Average Rating
7.8
Reviews Sentiment
6.6
Number of Reviews
8
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of August 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.0%, down from 13.2% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 1.9%, up from 1.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
HS
Easy to set up and use with a nice interface
The scalability could be better. We'd like them to be better at dealing with script threats. In sandboxing, the time to respond is slower than we would like. We'd like them to be able to process faster. For example, Fortinet, they are doing 18,000 files per hour. For Wildfire, it is elastic. It can support as many files as you get. McAfee doesn't react like that. It does not support interfaces with HTTPS.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The product's scalability is good."
"The most valuable feature of Microsoft Defender for Office 365 is its spam filter."
"We use Microsoft Defender for its ability to integrate with existing business technologies, which is beneficial for protecting business areas."
"Microsoft Defender for Office 365 helps people to work remotely. It is a secure solution. We don't need to use our company's computers or get VPN connections to the networks. I can control how they share screens and what they send to the devices. It keeps our organizations confidential and sensitive information safe."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"The good part is that you don't have to configure it, which is very convenient."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"It’s easy to handle integrations, and we don't need a lot of people in our IT team."
"Provides good exfiltration, and is an all-in-one product."
"The most valuable features are the administration console and its detection and response module."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"I recommend this solution because of its ease of use."
"It is stable and reliable."
"It is very scalable."
"It stops in excess of twenty-five malware events per month, all of which could be critical to the business."
 

Cons

"Microsoft Defender for Office 365 should improve the troubleshooting tools. It's unclear whether the device is blocked at the firewall level or at the device itself. The granularity needed for troubleshooting is currently lacking. From my perspective, Microsoft should address this issue to benefit many users who likely share the same sentiment."
"The GUI is sometimes slow to fetch the device report and could be improved."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"The phishing and spam filters could use some improvement."
"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"The pre-sales cost calculations could be more transparent."
"This solution needs to be made "cloud ready"."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
"Lacks remote capabilities not dependent on the internet."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"We'd like them to be better at dealing with script threats."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
 

Pricing and Cost Advice

"The product is expensive."
"I know that the product is incredibly expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"The pricing has become expensive."
"The product is very expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Our licensing fees for this solution are approximately one million dollars per year."
"The product is expensive, but it is better than the rest of them in the industry."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Government
6%
Government
17%
Manufacturing Company
15%
Comms Service Provider
11%
Financial Services Firm
10%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published. It's essential to enhan...
What do you like most about McAfee Advanced Threat Defense?
I recommend this solution because of its ease of use.
What needs improvement with McAfee Advanced Threat Defense?
There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client.
What is your primary use case for McAfee Advanced Threat Defense?
We use the solution for client management and security. We used the whole suite for client Firewall, antivirus, and everything provided by Trellix.
 

Also Known As

MS Defender for Office 365
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense and other solutions. Updated: July 2025.
864,155 professionals have used our research since 2012.