Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense

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Helped 894,668 peers since 2012

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Microsoft Defender for Offi...

Ranking in Advanced Threat Protection (ATP)

2nd

Average Rating

8.4

Reviews Sentiment

6.8

Number of Reviews

Ranking in other categories

Email Archiving (1st), Email Security (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (1st)

Trellix Advanced Threat Def...

Ranking in Advanced Threat Protection (ATP)

23rd

Average Rating

7.8

Reviews Sentiment

5.6

Number of Reviews

Ranking in other categories

No ranking in other categories

Mindshare comparison

As of May 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 6.7%, down from 14.9% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.1%, up from 1.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Advanced Threat Protection (ATP) Mindshare Distribution
Product	Mindshare (%)
Microsoft Defender for Office 365	6.7%
Trellix Advanced Threat Defense	2.1%
Other	91.2%

Advanced Threat Protection (ATP)

Featured Reviews

Emeka Ndulu

Cloud Solutions Architect at a tech services company with 201-500 employees

Improves threat visibility and response while reducing manual tasks and training users against phishing

I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Read full review

Philippe Panardie

RSSI at SDIS49

Ensuring long-term reliability while seeking internal email management enhancements

Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"There are several features that I consider valuable."

"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."

"The most valuable feature is the integration. It's a single console, so we don't have to switch around between multiple products. Another valuable feature is the ease of operations and maintenance."

"It definitely is a must for email protection and O365 app DLP, and combined with Microsoft Defender for Endpoint, Microsoft Defender for Identity, and MCAS, it provides a holistic solution for threat protection, email protection, O365 apps protection, and DLP for both internal and external risks."

"It has significantly decreased my time to detection and response."

"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."

"Defender has reduced the time our security team spends on tasks by 10 to 15 percent, allowing us to focus on other areas."

"Some of the valuable features on the email side are anti-phishing, anti-malware, and Safe Links."

More Microsoft Defender for Office 365 pros

"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."

"The most valuable features are the administration console and its detection and response module."

"The product is expensive, but it is better than the rest of them in the industry."

"It is very scalable."

"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."

"The features I find most valuable are: the management, the ability for automatic remediation of threats and it can successfully detect a threat, and to act upon it."

"It stops in excess of twenty-five malware events per month, all of which could be critical to the business."

More Trellix Advanced Threat Defense pros

Cons

"Microsoft Defender for Office 365 could improve by giving customers information on techniques to prevent threats."

"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."

"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."

"They can improve their security in a way where a customer can know if all their attachments are safe or not to open through a report. The solution does its job perfectly, but it never reports to the customer whether those attachments have been stopped before or not."

"Configuration requires going to a lot of places rather than just accessing one tab."

"The changes to customer service, specifically the new model for support agreements, are not favorable."

"Several simulation options are available within 365, and the phishing simulation could be better."

"Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published."

More Microsoft Defender for Office 365 cons

"I would like to see future versions of the solution incorporate artificial intelligence technology."

"We'd like them to be better at dealing with script threats."

"Lacks remote capabilities not dependent on the internet."

"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."

"Some of our customers have mentioned the lack of a tool that would allow for remote capabilities without being attached to the internet."

"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."

"It was not complex, but there are things to look out for, because it's an intense product. It scans intensely and there are major obstacles to overcome if it scans while users are using a network, then it is not a good thing."

"The support on their side is not readily available. It takes a while."

More Trellix Advanced Threat Defense cons

Pricing and Cost Advice

"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."

"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."

"It is much more expensive than using another solution because we have had to include some options and upgrade our license."

"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."

"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."

"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."

"It's a user-base subscription."

"The license is expensive because the cost is based on the number of users."

More Microsoft Defender for Office 365 pricing and cost advice

"The product is expensive, but it is better than the rest of them in the industry."

"Our licensing fees for this solution are approximately one million dollars per year."

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894,668 professionals have used our research since 2012.

Top Industries

By visitors reading reviews

Computer Software Company

12%

Financial Services Firm

Manufacturing Company

Comms Service Provider

Construction Company

16%

Comms Service Provider

12%

Outsourcing Company

11%

Financial Services Firm

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	24
Midsize Enterprise	12
Large Enterprise	32

By reviewers
Company Size	Count
Small Business	3
Midsize Enterprise	4
Large Enterprise	5

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?

My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...

What needs improvement with Microsoft Defender for Office 365?

I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...

What is your primary use case for Microsoft Defender for Office 365?

My main use cases for Microsoft Defender for Office 365 include email hygiene.

What needs improvement with McAfee Advanced Threat Defense?

I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...

What is your primary use case for McAfee Advanced Threat Defense?

We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...

What advice do you have for others considering McAfee Advanced Threat Defense?

Proofpoint Email Protection vs Microsoft Defender for Office 365

Comparisons

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Check Point Email Security (formerly Harmony Email & Collaboration) vs Microsoft Defender for Office 365

Compared 5% of the time

Barracuda Email Protection vs Microsoft Defender for Office 365

Compared 4% of the time

Cisco Secure Email vs Microsoft Defender for Office 365

Compared 4% of the time

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Digital Guardian vs Trellix Advanced Threat Defense

Compared 10% of the time

Fortinet FortiSandbox vs Trellix Advanced Threat Defense

Compared 10% of the time

Check Point Infinity vs Trellix Advanced Threat Defense

Compared 10% of the time

Microsoft Defender for Identity vs Trellix Advanced Threat Defense

Compared 6% of the time

Morphisec vs Trellix Advanced Threat Defense

Compared 6% of the time

More Trellix Advanced Threat Defense Competitors

Product Reports

Microsoft Defender for Office 365

Download Microsoft Defender for Office 365 product report

Microsoft Defender for Office 365 report

Trellix Advanced Threat Defense

Download Trellix Advanced Threat Defense product report

Also Known As

MS Defender for Office 365

McAfee Advanced Threat Defense

Overview

Microsoft Defender for Office 365 offers real-time email security, enhancing threat detection through integration within the Microsoft ecosystem. Its user-friendly interface and central management streamline operations, providing robust protection against phishing, ransomware, and malware.

Defender for Office 365 is focused on efficiently securing email communication by safeguarding against phishing, malware, and spam threats. With its strong integration with other Microsoft services, it is tailored to improve endpoint security and identity protection. Its centralized management tools simplify threat prioritization, while the automated threat response capabilities ensure swift actions against potential risks. Organizations leverage its capabilities to efficiently manage their cybersecurity efforts, particularly in remote work environments, while maintaining a secure system across Office 365 applications and Azure-hosted services.

What are the key features?

Real-time Email Protection: Continuously monitors and protects email communications.
Safe Attachments and Links: Scans attachments and links for potential threats.
Anti-Phishing Measures: Provides tools to detect and block phishing attempts.
Integration with Microsoft Services: Seamlessly connects with other Microsoft applications for enhanced security.
Automated Threat Responses: Activates immediate responses to detected threats.

What benefits should users expect from reviews?

Time Savings: Automates processes to reduce manual threat management efforts.
Improved Cybersecurity: Strengthens organizational defenses against various cyber threats.
Efficient Remote Work: Enhances protection for remote teams and virtual collaborations.
Comprehensive Coverage: Extends protection across Office 365 and Azure services.

Implementations of Defender for Office 365 vary across industries, optimizing email security for sectors such as finance, healthcare, and education. In finance, it aids in protecting sensitive financial data from phishing and fraud. Healthcare benefits from secure communications, ensuring patient data privacy. Educational institutions use it to maintain secure virtual learning environments against cyber threats.

Microsoft

Trellix Advanced Threat Defense offers efficient threat detection and automatic threat remediation, featuring seamless management and integration with operating systems and extensions.

Providing robust malware defense, Trellix Advanced Threat Defense is easy to set up and use. Its components work collaboratively, with standout features like behavioral analysis, retro-inspection, and ePolicy Orchestration. Despite its strengths, users suggest improvements in Active Directory integration, cloud readiness, artificial intelligence, and faster sandboxing. The API interface and scalability need enhancement, while better compatibility with platforms like Cisco could elevate its function. Effective for server and endpoint security, it effectively blocks threats like WannaCry and disperses attack data through the DXL client quickly.

What are the notable features of Trellix Advanced Threat Defense?

Management and Automatic Threat Remediation: Facilitates seamless management and handling of threats.
Effective Threat Detection and Response: Delivers efficient and reliable threat detection capabilities.
Behavioral Analysis and Retro-Inspection: Offers advanced analysis for comprehensive threat identification.
ePolicy Orchestration: Streamlines processes for enhanced threat management.
Scalability and Price: Provides a stable and scalable solution at a competitive price point.

What key benefits can be identified from reviews?

Ease of Use and Setup: Known for its straightforward implementation and user-friendly interface.
Integration Capabilities: Works well with different operating systems and technologies like Palo Alto firewalls.
Threat Protection Efficiency: Proven effectiveness in stopping threats such as WannaCry.
Rapid Attack Information Dissemination: Utilizes the DXL client for quick data sharing.

Trellix Advanced Threat Defense is widely used across numerous industries for server and desktop protection, ensuring endpoint security and halting attacks without failure. Its integration with diverse technologies enhances protection in varied environments, making it a valuable tool in enterprise security management.

Trellix

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.

The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust

Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense