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Microsoft Defender Threat Intelligence [EOL] vs ThreatLocker Zero Trust Endpoint Protection Platform comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Oct 16, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
8.2
Microsoft Defender Threat Intelligence enhances security, saves on budgets, and improves detection, offering significant ROI and value.
Sentiment score
7.9
ThreatLocker Zero Trust boosts ROI by blocking threats, reducing risks, and enhancing security with seamless integration and quick adaptation.
It's a value-for-money product.
Mobility & IT Project Manager at Voicevine Pty Ltd
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
Tier 1 IT Engineer at a retailer with 11-50 employees
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
Project Engineer at Lutz M&A, LLC
It keeps malware, Trojans, and ransomware at bay.
Technical Engineer at Cloud 1 Solutions
 

Customer Service

Sentiment score
7.5
Microsoft Defender support is rated very good, with knowledgeable level two assistance, competent partners, and a helpful community platform.
Sentiment score
7.7
ThreatLocker offers exceptional 24/7 customer service with fast issue resolution, highly rated by users for speed and expertise.
Level two support is knowledgeable and knows how the product works, which is very good.
Cloud Solution architect at a tech services company with 51-200 employees
I would give Microsoft an eight for their technical support.
Mobility & IT Project Manager at Voicevine Pty Ltd
They have been very responsive, helpful, and knowledgeable.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate their customer support a ten out of ten.
Director, Managed Services at a consultancy with 11-50 employees
Their support is world-class.
Supervisor, Client Security at a consultancy with 11-50 employees
 

Scalability Issues

Sentiment score
7.4
Microsoft Defender Threat Intelligence is highly scalable, adaptable for businesses of all sizes, and supports thousands of endpoints efficiently.
Sentiment score
8.0
ThreatLocker scales efficiently, handling thousands of endpoints easily, with updates and flexible deployment supporting diverse organizational needs.
If there were some customizations available, I would rate its scalability as nine out of ten.
Cloud Solution architect at a tech services company with 51-200 employees
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
Technical Engineer at Cloud 1 Solutions
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate it a ten out of ten for scalability.
Project Engineer at Lutz M&A, LLC
 

Stability Issues

Sentiment score
8.0
Microsoft Defender Threat Intelligence is seen as stable and secure, with high reliability and effective phishing prevention despite occasional outages.
Sentiment score
7.4
ThreatLocker Zero Trust Platform offers stable performance, minimal downtime, quick issue resolution, and seamless integration with operating systems.
It provides a high level of security and avoids phishing and scam emails.
Cloud Solution architect at a tech services company with 51-200 employees
For five years, we have not had a problem.
Supervisor, Client Security at a consultancy with 11-50 employees
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
Information Cybersecurity Technology Specialist at Freez.it
It has been very stable, reliable, and accessible.
COO at Panda Technology
 

Room For Improvement

Microsoft Defender needs price adjustments, improved integration, better accuracy, enhanced AI, and smoother user experience for evolving cybersecurity.
ThreatLocker could improve by enhancing training, UI, reporting, integration, and support to address approval and update challenges.
Providing code customization would help keep pace with new vulnerabilities and threats.
Cloud Solution architect at a tech services company with 51-200 employees
The main area of improvement for Microsoft Defender Threat Intelligence is related to how information is conveyed.
Mobility & IT Project Manager at Voicevine Pty Ltd
From the telemetry data standpoint, I would prefer Defender data to be more open in future updates.
Consultant at Dell Technologies
Controlling the cloud environment, not just endpoints, is crucial.
COO at Panda Technology
This is problematic when immediate attention is needed.
Senior System Administrator at Molders Group Limited
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
IMS ENGINEER at a tech vendor with 1,001-5,000 employees
 

Setup Cost

Microsoft Defender Threat Intelligence is cost-effective in bundles, but SMEs face challenges with standalone pricing and evolving licensing.
ThreatLocker offers a cost-effective Zero Trust solution with flexible pricing, appreciated for transparency and easy setup across clients.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
Director, Managed Services at a consultancy with 11-50 employees
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
Supervisor, Client Security at a consultancy with 11-50 employees
I had a really good deal at the time, and it continues to be cost-effective.
Cyber Security Specialist at Bremmar Consulting
 

Valuable Features

Microsoft Defender Threat Intelligence excels in integration, threat detection, user interface, data retention, real-time protection, and analytics.
ThreatLocker enhances security and reduces costs with application control, instant support, intuitive interface, and comprehensive training resources.
If it wasn't for that real-time threat detection on the vulnerability, I think we would not have survived the attack.
Mobility & IT Project Manager at Voicevine Pty Ltd
One of the best features is that it provides a certain level of customization, allowing us to set our spam confidence levels.
Cloud Solution architect at a tech services company with 51-200 employees
Our threat detection is enhanced due to the AI agents in Microsoft Defender Threat Intelligence, which helps in detecting automatically.
Consultant at Dell Technologies
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
Cyber Security Specialist at Bremmar Consulting
It protects our customers.
CTO at Zettabytes
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
Tier 1 IT Engineer at a retailer with 11-50 employees
 

Categories and Ranking

Microsoft Defender Threat I...
Average Rating
8.4
Reviews Sentiment
7.3
Number of Reviews
32
Ranking in other categories
No ranking in other categories
ThreatLocker Zero Trust End...
Average Rating
9.2
Reviews Sentiment
7.4
Number of Reviews
40
Ranking in other categories
Network Access Control (NAC) (4th), Endpoint Protection Platform (EPP) (6th), Advanced Threat Protection (ATP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
 

Featured Reviews

Charles Mokoena - PeerSpot reviewer
Mobility & IT Project Manager at Voicevine Pty Ltd
Has strengthened our ability to detect threats in real time and improved internal security decision-making
The features that I find most valuable in Microsoft Defender Threat Intelligence include the Sentinel part of it. There are several features we've looked at, including Sentinel as well as extended Defender, which is XDR. I've used those two, and that's what I've found quite useful for us, especially in the hardening and analysis part of the whole threat analysis. We use the real-time threat detection features in Microsoft Defender Threat Intelligence. If it wasn't for that real-time threat detection on the vulnerability, I think we would not have survived the attack. The integration capabilities of Microsoft Defender Threat Intelligence with other Microsoft security tools have benefited our organization's threat management process by initially being quite a challenge, especially coming from other security tools such as Fortinet and Check Point. However, once you've gotten used to it, it's quite easy and user-friendly. The dashboard, especially the threat analysis dashboard, is quite detailed in terms of providing a view of which areas in our environment need attention, making it quite useful.
CL
Supervisor, Client Security at a consultancy with 11-50 employees
World-class support and highly effective for application control and elevation
Their product is solid. I have a hard time complaining much about it because when we do find little things, they are usually interface-related or related to things that would be nice to have. Their idea portal, unlike so many other vendors we deal with, shows movement. At least four to eight features of ThreatLocker exist because I made a request in the last five years, and it became a feature of the actual product. When it comes to improvements, we moved the product as customers, and we got to move the product by making suggestions. They seem to be very reactive to it, so there is not a whole lot that they actively need to change right now. It is one of those situations where when we run into something that would be nice to have, it happens. They make it work.
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Top Industries

By visitors reading reviews
Financial Services Firm
16%
Computer Software Company
11%
Educational Organization
9%
Manufacturing Company
9%
Computer Software Company
22%
Retailer
8%
Manufacturing Company
7%
Financial Services Firm
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business17
Midsize Enterprise2
Large Enterprise15
By reviewers
Company SizeCount
Small Business32
Midsize Enterprise4
Large Enterprise3
 

Questions from the Community

What do you like most about Microsoft Defender Threat Intelligence?
It just runs in the background. I don't have to worry about, making sure it's Intelligence. So, you know, this kind of makes it very easy, have to worry about installing. It is easy to use.
What needs improvement with Microsoft Defender Threat Intelligence?
From the telemetry data standpoint, I would prefer Defender data to be more open in future updates.
What is your primary use case for Microsoft Defender Threat Intelligence?
We have tried Microsoft Defender Threat Intelligence. I have expertise with Microsoft Defender products. I am not familiar with Microsoft Defender for IoT because we did not use that in our environ...
What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
Going with the theme of ThreatLocker Zero Trust Endpoint Protection Platform being a one-stop shop where they have just about everything, and they have a really good product stack as is. However, t...
 

Also Known As

No data available
Protect, Allowlisting, Network Control, Ringfencing
 

Overview

Find out what your peers are saying about Palo Alto Networks, Microsoft, Proofpoint and others in Advanced Threat Protection (ATP). Updated: January 2026.
881,757 professionals have used our research since 2012.