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Cisco Secure Endpoint vs ThreatLocker Zero Trust Endpoint Protection Platform comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Mar 23, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Cisco Secure Endpoint enhances productivity and reduces costs by streamlining threat detection, integrating tools, and minimizing manual intervention.
Sentiment score
8.1
ThreatLocker Zero Trust Platform enhances security, improves efficiency, saves costs, increases revenue, and supports business growth by reducing threats.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
It keeps malware, Trojans, and ransomware at bay.
 

Customer Service

Sentiment score
6.1
Cisco Secure Endpoint support is praised for responsiveness and expertise, providing quick issue resolution and valuable user guidance.
Sentiment score
8.8
ThreatLocker Zero Trust's responsive customer service, highlighted by the Cyber Hero program, is praised for speed, professionalism, and effectiveness.
Cisco has good technical support, especially considering these are newer solutions compared to traditional routing and switching products.
They have been very responsive, helpful, and knowledgeable.
I would rate their customer support a ten out of ten.
Their support is world-class.
 

Scalability Issues

Sentiment score
8.4
Cisco Secure Endpoint is scalable, integrates with SecureX for efficient management, and supports diverse industries without extra resources.
Sentiment score
8.2
ThreatLocker Zero Trust Platform offers seamless scalability and adaptability, efficiently managing diverse environments and dynamic growth across endpoints.
Cisco Secure Endpoint is definitely scalable.
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
I would rate it a ten out of ten for scalability.
 

Stability Issues

Sentiment score
6.5
Cisco Secure Endpoint is highly stable, reliable, and trusted for performance, earning high ratings from users in various enterprises.
Sentiment score
7.5
ThreatLocker Zero Trust Platform is praised for stability and reliability, with minor issues swiftly addressed by support.
We have not encountered any problems.
For five years, we have not had a problem.
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
It has been very stable, reliable, and accessible.
 

Room For Improvement

Cisco Secure Endpoint requires better integration, reporting, and UI enhancements, alongside improved pricing, AI capabilities, and IoT support.
ThreatLocker needs UI improvements, better integrations, expanded training, enhanced analytics, restricted Learning Mode, and faster support.
The forensic capabilities need enhancement, especially for deep forensic data collection.
Controlling the cloud environment, not just endpoints, is crucial.
This is problematic when immediate attention is needed.
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
 

Setup Cost

Cisco Secure Endpoint offers competitive and flexible pricing with value-rich features, despite some complexity in licensing.
Enterprise buyers find ThreatLocker's pricing competitive and flexible, valuing its affordability, transparency, and accessible setup costs.
Cisco is aggressive in pricing, making it competitive and sometimes even cheaper than other good products like CrowdStrike, Microsoft Defender, or SentinelOne.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
I had a really good deal at the time, and it continues to be cost-effective.
 

Valuable Features

Cisco Secure Endpoint provides advanced security features, cross-platform support, and ease of use with strong threat intelligence and support.
ThreatLocker Zero Trust Platform enhances security with features like application control, selective elevation, and robust network access controls.
Cisco Secure Endpoint is very good in machine learning, which allows it to secure offline contents even if not connected to the internet.
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
It protects our customers.
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
 

Categories and Ranking

Cisco Secure Endpoint
Ranking in Endpoint Protection Platform (EPP)
12th
Average Rating
8.6
Reviews Sentiment
7.2
Number of Reviews
49
Ranking in other categories
Endpoint Detection and Response (EDR) (15th), Cisco Security Portfolio (6th)
ThreatLocker Zero Trust End...
Ranking in Endpoint Protection Platform (EPP)
7th
Average Rating
9.2
Reviews Sentiment
7.6
Number of Reviews
39
Ranking in other categories
Network Access Control (NAC) (5th), Advanced Threat Protection (ATP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (2nd)
 

Mindshare comparison

As of June 2025, in the Endpoint Protection Platform (EPP) category, the mindshare of Cisco Secure Endpoint is 1.5%, down from 1.9% compared to the previous year. The mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 0.8%, down from 0.8% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Protection Platform (EPP)
 

Featured Reviews

Ahmed-Dawood - PeerSpot reviewer
A tool that offers good performance and technical support along with great protection to endpoint devices
The vendor from Cisco takes care of the maintenance. We need three people to take care of the tool in case of crashes. From the dashboard, we come to know about everything related to the endpoint. You can take action unless it is not the physical hardware to which something wrong has happened, especially if something wrong happens to the operating system. I would definitely recommend the solution to those planning to use it. To provide endpoint protection, I feel the product should be speedy enough to detect malicious programs and trojans. There are a lot of tools that are not acting as signature-based but as behavior-based antivirus. Cisco Secure Endpoint is required, especially if the customers don't have a sandbox. Overall, I rate the product an eight out of ten.
Johnathan Bodily - PeerSpot reviewer
Ensures ransomware protection and reduces phishing chaos
The application control has been great so far, and while I am still exploring the network access controls, I unfortunately don't have access to one module I would love to have due to licensing restrictions. It's easy to use in regard to reducing attack surfaces. For me, it's a piece of cake. We can have something approved within 30 seconds, thanks to the mobile app. We haven't eliminated security solutions. We just add to it, and ThreatLocker has been a great addition. We also have Kaseya and ThreatLocker as a supplement to that. It's useful. They have overlap, and we look at the overlap as a good thing. It's helped your organization save on operational costs or expenses by ensuring that many fewer hours are spent dealing with ransomware nonsense. I cannot count the amount of hours that I personally have not had to put in to recovering an environment from a ransomware event. The last big one took us about three weeks to completely recover from. Since we've grouped ThreatLocker in, the management of that whole setup has gone down to just daily help desk tasks and general server maintenance instead of having the whole system on fire. There are probably thousands of hours of saved time between our teams. It's been great so far. ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications is great. It's my biggest protection, the blocked applications. In a lot of cases, you go to install something yourself that you need for management, and it comes in and says, nope. And then I have to log into the portal and approve it. I get our other guys saying, hey, why are you trying to approve something? Any of the tools that I'm using on a day-to-day basis that haven't been in the environment during the whole learning mode initially, I could go through and set extensions and all that. So, while it's a headache on that end, the amount of saved time I can't even count. It is a little frustrating on my end since I like to go as quickly as I possibly can, and it slows me down. However, that's a really good thing. Depending on the site, it can save a lot of time and cut down headaches. It's likely saved a week's worth of time. It's cut down the amount of sever help desk tickets. Those have become minimal.
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Top Industries

By visitors reading reviews
Computer Software Company
22%
Manufacturing Company
8%
Government
8%
Financial Services Firm
7%
Computer Software Company
35%
Retailer
8%
Manufacturing Company
5%
Financial Services Firm
5%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Cisco Secure Endpoint?
The product's initial setup phase was very simple.
What is your experience regarding pricing and costs for Cisco Secure Endpoint?
Cisco is aggressive in pricing, making it competitive and sometimes even cheaper than other good products like CrowdStrike, Microsoft Defender, or SentinelOne.
What needs improvement with Cisco Secure Endpoint?
Cisco Secure Endpoint lacks features like DLP which other vendors offer. XDR is new, so integration capabilities with third-party tools need improvement. The forensic capabilities need enhancement,...
What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
For the space that it's in, it's already there. I don't know of another product that compares to its level. Even recently, with the addition of the detect module is a very nice add-on to the packet...
 

Also Known As

Cisco AMP for Endpoints
Protect, Allowlisting, Network Control, Ringfencing
 

Overview

 

Sample Customers

Heritage Bank, Mobile County Schools, NHL University, Thunder Bay Regional, Yokogawa Electric, Sam Houston State University, First Financial Bank
Information Not Available
Find out what your peers are saying about Cisco Secure Endpoint vs. ThreatLocker Zero Trust Endpoint Protection Platform and other solutions. Updated: June 2025.
859,438 professionals have used our research since 2012.