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Microsoft Defender for Endpoint vs Palo Alto Networks WildFire comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.9
Microsoft Defender for Endpoint offers significant ROI with cost savings, seamless integration, and real-time protection against ransomware attacks.
Sentiment score
6.5
Palo Alto Networks WildFire provides cost-effective, centralized threat management, reducing security costs and improving efficiency in high-threat environments.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
Consultant at ACT4SERVICES
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
IT CONSULTANT at a tech company with 10,001+ employees
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
Lead security engineer at a computer software company with 11-50 employees
The service generates a low rate of false positives, reducing the overhead of managing false positive events.
Presale Engineer at Westcon-Comstor
 

Customer Service

Sentiment score
6.4
Many users find Microsoft Defender for Endpoint reliable, but support experiences vary, with premium support offering quicker assistance.
Sentiment score
7.0
Palo Alto Networks WildFire's support is responsive and expert but varies in availability and response time, especially for smaller companies.
The Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, 'Just to set expectations, my lunch break is in an hour and I am going to go away then.'
Security Analyst III at a healthcare company with 10,001+ employees
The level-one support seems disconnected from subject matter experts.
Office 365 Subject Expert at a government with 10,001+ employees
I rate Microsoft support 10 out of 10.
Team manager of it department at a financial services firm with 501-1,000 employees
There is a lack of SLA adherence, and third-party partners do not provide prompt responses.
Technical Superintendent at Indian Institute Of Technology, Patna
The service response times are aligned with standards, responding within a few hours based on the problem's criticality.
Presale Engineer at Westcon-Comstor
The support is quite difficult to access promptly.
Content Specialist at PeerSpot
 

Scalability Issues

Sentiment score
7.4
Microsoft Defender for Endpoint is scalable and integrates well with Microsoft’s ecosystem, despite needing improvements for handling massive data.
Sentiment score
8.2
Palo Alto Networks WildFire efficiently scales for diverse environments, supporting thousands of users while integrating well with security modules.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Compatibility is its main feature.
IT CONSULTANT at a tech company with 10,001+ employees
Wildfire is highly scalable.
Technical Superintendent at Indian Institute Of Technology, Patna
Palo Alto Networks WildFire is scalable, and I give it a nine for scalability.
Content Specialist at PeerSpot
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is praised for its reliability and stability, with minor concerns about resource intensity and performance.
Sentiment score
8.5
Palo Alto Networks WildFire is highly rated for reliability, seamless integration, and effective network security performance without disruptions.
I haven't seen any outages with Microsoft.
IT Security Engineer at a financial services firm with 1,001-5,000 employees
I rate Defender 10 out of 10 for stability.
Team manager of it department at a financial services firm with 501-1,000 employees
Defender for Endpoint is extremely stable.
Systems engineers at Delta Dental of Colorado
It performs filtering, malware blocking, and scanning.
Engineer at Taalumgroup
The solution is scalable and stable.
Technical Manager at PSR
 

Room For Improvement

Microsoft Defender for Endpoint faces interface complexity, slow detection, high CPU usage, integration issues, and seeks improvements in multiple areas.
WildFire needs improvements in integration, user-friendliness, and pricing, along with better support, automation, and global availability.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
Office 365 Subject Expert at a government with 10,001+ employees
In contrast, competing products offer reduced pricing for long-term commitments, which makes it difficult for us in that environment.
Solution Consultant at BIM Group of Companies
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Team manager of it department at a financial services firm with 501-1,000 employees
The dashboard should provide better visibility, especially in showing how many files are sent to Wildfire and their findings.
Technical Superintendent at Indian Institute Of Technology, Patna
It is a very good product.
Engineer at Taalumgroup
The support could be improved, as it takes a while to get assistance from the vendors.
Content Specialist at PeerSpot
 

Setup Cost

Microsoft Defender for Endpoint offers flexible pricing, making it competitive and cost-effective compared to standalone security products.
Palo Alto WildFire offers advanced threat protection, appealing to enterprises despite its high cost, potentially deterring smaller organizations.
That has been the trend we have seen with Microsoft lately—it is just getting more and more expensive.
Assistant Director, Hybrid Infrastructure & Operations at a insurance company with 501-1,000 employees
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
Team manager of it department at a financial services firm with 501-1,000 employees
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
Snr. Infrastructure Architect (Data Centre) at LogicEra
I would rate it an eight out of ten in terms of affordability.
Presale Engineer at Westcon-Comstor
 

Valuable Features

Microsoft Defender for Endpoint excels with seamless integration, advanced threat intelligence, AI-driven protection, and continuous cloud-based security management.
Palo Alto Networks WildFire automates threat analysis, excels in sandboxing, and offers robust security with cloud-based, user-friendly features.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
Snr. Infrastructure Architect (Data Centre) at LogicEra
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
Consultant at ACT4SERVICES
Integrating Palo Alto Networks WildFire with various security protocols similar to a firewall has significantly improved the overall threat detection capabilities in our organization.
Content Specialist at PeerSpot
The most valuable feature of Wildfire is its sandboxing capability for examining suspicious files or locations.
Technical Superintendent at Indian Institute Of Technology, Patna
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
3rd
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
210
Ranking in other categories
Endpoint Protection Platform (EPP) (2nd), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (2nd), Microsoft Security Suite (3rd)
Palo Alto Networks WildFire
Ranking in Advanced Threat Protection (ATP)
1st
Average Rating
8.4
Reviews Sentiment
7.2
Number of Reviews
71
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of December 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 7.5%, down from 9.2% compared to the previous year. The mindshare of Palo Alto Networks WildFire is 8.5%, down from 12.7% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Palo Alto Networks WildFire8.5%
Microsoft Defender for Endpoint7.5%
Other84.0%
Advanced Threat Protection (ATP)
 

Featured Reviews

Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.
RK
Engineer at Taalumgroup
Achieve effective threat prevention and seamless integration with powerful technical support
Integration with third-party products is possible. For example, connecting a mail gateway with Palo Alto Networks WildFire allows them to handle prevention. Palo Alto Networks WildFire is a cloud-based sandboxing solution. The firewall is connected to WildFire, and XDR performs sandboxing from the cloud. WildFire conducts malware scanning and emulation, then informs the firewall to block threats based on the response. It also generates reports regarding malware and other issues. The sandboxing process involves sending sample files to the cloud for scanning, checking file authenticity, certificates, and detecting malicious code. WildFire performs multiple checks and informs the XDR agent about file status. This automatic process occurs within minutes or seconds. For unknown or suspicious files, immediate blocking occurs while samples are sent to WildFire for identification. I rate Palo Alto Networks WildFire a 9 out of 10.
report
Use our free recommendation engine to learn which Advanced Threat Protection (ATP) solutions are best for your needs.
879,259 professionals have used our research since 2012.
 

Comparison Review

it_user206346 - PeerSpot reviewer
Security Consultant at Webernetz.net - Network Security Consulting
Mar 11, 2015
Cisco ASA vs. Palo Alto Networks
Cisco ASA vs. Palo Alto: Management Goodies You often have comparisons of both firewalls concerning security components. Of course, a firewall must block attacks, scan for viruses, build VPNs, etc. However, in this post I am discussing the advantages and disadvantages from both vendors concerning…
 

Top Industries

By visitors reading reviews
Computer Software Company
12%
Manufacturing Company
9%
Financial Services Firm
8%
Government
8%
Computer Software Company
14%
Financial Services Firm
9%
Manufacturing Company
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business80
Midsize Enterprise40
Large Enterprise92
By reviewers
Company SizeCount
Small Business36
Midsize Enterprise16
Large Enterprise29
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
How does Cisco Firepower NGFW Firewall compare with Palo Alto Networks Wildfire?
The Cisco Firepower NGFW Firewall is a very powerful and very complex piece of anti-viral software. When one considers that fact, it is all the more impressive that the setup is a fairly straightf...
Which is better - Wildfire or FortiGate?
FortiGate has a lot going for it and I consider it to be the best, most user-friendly firewall out there. What I like the most about it is that it has an attractive web dashboard with very easy nav...
How does Cisco ASA Firewall compare with Palo Alto's WildFire?
When looking to change our ASA Firewall, we looked into Palo Alto’s WildFire. It works especially in preventing advanced malware and zero-day exploits with real-time intelligence. The sandbox featu...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
No data available
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Novamedia, Nexon Asia Pacific, Lenovo, Samsonite, IOOF, Sinogrid, SanDisk Corporation
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Palo Alto Networks WildFire and other solutions. Updated: December 2025.
879,259 professionals have used our research since 2012.