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Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco HyperFlex HX-Series [...
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
90
Ranking in other categories
No ranking in other categories
Nutanix Cloud Infrastructur...
Average Rating
8.6
Reviews Sentiment
7.4
Number of Reviews
198
Ranking in other categories
Software Defined Storage (SDS) (5th), HCI (3rd), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (4th)
 

Featured Reviews

Nuno Mendes - PeerSpot reviewer
High performance solution that makes it easy to efficiently manage VM resources
In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).
Andrea Beccia - PeerSpot reviewer
Offers satisfying data protection and workload movement features with exceptional stability
Nutanix Cloud Infrastructure can be used up to 100% of its capacity, but our company is presently using 80% of the solution's resources. Our company manufactures iron casting products in the metal industry, and Nutanix Cloud Infrastructure is also used. For virtualization purposes, Nutanix Acropolis is used as a full-stack solution. For the Windows virtual machines in our company's server, Nutanix Acropolis is utilized instead of solutions like VMware Hypervisor. One of the main reasons our company adopted Nutanix Cloud Infrastructure was its data protection features. The solution is also used in disaster recovery through the automatic snapshots feature on the local site. Next year, our organization will try to join clusters in the network using the solution. Network clustering will help our organization's team move workloads into the geographical cluster automatically. Nutanix Cloud Infrastructure is considered an ideal solution for disaster recovery where data protection remains embedded. The solution is capable of even capturing auto snapshots for remote sites. Next year, our company plans to test new features of Nutanix Cloud Infrastructure that will assist in automated workload movements on two sides at a distance of 60 kilometers. I would recommend others use the solution for its exceptional stability, performance, hardware compatibility, and overall flexibility. Nutanix Cloud Infrastructure allows the use of varying hardware for the same cluster. I would rate the solution a nine out of ten overall.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I love the Cisco design, the visual interface to manage and use the platform."
"It is a complete package. For any kind of on-premises hyper-converged solution, we usually have to separate networks, but Cisco HyperFlex HX-Series is a complete solution. It has its own network and storage. The storage part is the most valuable feature."
"Easy to spin up and operate virtual machines without the overhead of managing a storage network."
"Great integration with backup software."
"Deduplication is a valuable feature available in Cisco HyperFlex."
"Cisco technical support is very skilled. From what I've had to access, there were quick responses and the necessary escalation."
"The speed, storage, and management are the most valuable features."
"You can administer things easily. E.g., if you need more power, you can add a system."
"The simplicity when it comes to building your own automation has been excellent."
"The snapshots, cloning, and replication are all effective in helping to reduce downtime. It can replicate cluster data for disaster recovery and it provides high availability in case a node or a disk fails."
"What's best about Nutanix Acropolis AOS is its simplicity. It's simple to install and simple to understand. The technical support and support portal for this product are both very good and very helpful."
"The maintenance software is straightforward because you do not need to do any configuration."
"One of the most valuable features is the One-Click Upgrade. When I need to update the system, I do it with one click. This product is amazing because everything is easy to manage, from network management to snapshots."
"Nutanix Cloud Infrastructure's most valuable features are all the cloud facilities or benefits it provides for my data center."
"The initial setup was quite straightforward."
"Its most valuable feature is simplicity. It is so easy to use. Upgrades are easy. It is easy in terms of disaster recovery, failover, database provisioning, and reporting. Everything about it is just simple."
 

Cons

"Deployment on-prem was quite difficult."
"The architecture separates data, computing, memory, and storage into different parts."
"Cisco's technical support originally was outstanding, but it has declined over the last 12 months. I've heard they're trying to do better, but I haven't been overly impressed with their support recently for HyperFlex."
"When it comes to customer needs, the licensing price could be better."
"The setup was complex, especially since we usually do all the planning, sizing, and workflows before integration."
"We had a bit of complexity to think about how to migrate our legacy infrastructure into Cisco HyperFlex."
"We need to be able to scale out and not just up. When you want to scale up or scale out, you are quite limited."
"The price could be better. I think it's more expensive than VxRail. In the next release, I would like to see a better level of protection and availability with six clients."
"In the future, I would like to see multi-tenancy in Nutanix Acropolis AOS."
"The look and feel of the web GUI of this system needs improvement, when compared to other systems. Its hardware integration also needs improvement."
"NCI's pricing is expensive."
"It would be great if it could emulate some of the features that their competitor VMware has, for example port mirroring or Netflow output at hypervisor level."
"The file services that they also provide need some more features, like on the Windows file server."
"Nutanix needs to improve network features like Passthrough – SR-IOV. It could be improved by supporting SR-IOV, if they had that support, I would not have needed to implement the VMWare vSAN."
"The only problem is that not many operating systems are supported on the AOS hypervisor. They need to probably increase the support on multiple operating systems. As of now, a very limited number of operating systems and patch levels are supported on AOS."
"One disadvantage of Nutanix Acropolis AOS is it doesn't support external storage. Connecting external SAN storage to Nutanix, it's not supported."
 

Pricing and Cost Advice

"One of the challenges we have with HyperFlex is that they have a subscription fee for the operating system that runs on it, and if I remember correctly, it costs approximately $15,000 USD per month."
"We currently have a perpetual license, which is kind of unlimited, so we don't have the normal licensing cost, yet."
"It is relatively expensive, but it can easily return value by freeing up other resources."
"There is a license required to use this solution."
"HyperFlex is relatively expensive, but you get good value for money."
"It's much more expensive than rack servers. It was an issue, but when you compare it to the number of people who were administrative assistants before, it's on the positive ROI side. It's much cheaper."
"Our licensing costs are large, but it is combined between all of the Cisco products that we have."
"We negotiated with Cisco and we got some price benefit from that."
"It is not cheap, but if you look at the return on investment and the total cost of ownership, it is worth the price."
"We got the renewal done recently, and there was no cost involved."
"Nutanix Cloud Infrastructure could be cheaper. It's costly to upgrade the solution. There are no additional costs aside from the license."
"Pricing varies greatly between license and editions."
"The basic license that comes with the box allows basic virtualization features but advanced automation features would require an upgrade of licenses."
"Cost-wise, it is very good. It is like the hypervisor cost is not there. We only need to pay for the system and AOS licenses."
"The overall cost depends on the contract of each customer and the discounts they have, but the price for the three-tier architecture can be slightly lower."
"We are aware of the pricing since we renew every year, at almost $100,000 per year."
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Comparison Review

it_user244362 - PeerSpot reviewer
Aug 30, 2015
Nutanix vs. VMware EVO:RAIL vs. FlexPod
Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…
 

Answers from the Community

NC
Aug 2, 2022
Aug 2, 2022
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrat...
See 2 answers
Oct 17, 2021
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.
Steffen Hornung - PeerSpot reviewer
Aug 2, 2022
With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.
 

Top Industries

By visitors reading reviews
Computer Software Company
24%
Financial Services Firm
9%
Government
8%
Manufacturing Company
7%
Educational Organization
33%
Computer Software Company
13%
Financial Services Firm
7%
Manufacturing Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...
How does VxRail compare with Cisco HyperFlex HX Series?
VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...
What is the biggest difference between Nutanix Acropolis and VMware vSphere?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
Which would you choose - Nutanix Acropolis AOS or VMware vSAN?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
What makes Nutanix Cloud Infrastructure (NCI) worth using?
NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...
 

Also Known As

No data available
Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis
 

Overview

 

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest
St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.
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