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Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Jul 27, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco HyperFlex HX-Series [...
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
90
Ranking in other categories
No ranking in other categories
Nutanix Cloud Infrastructur...
Average Rating
8.6
Reviews Sentiment
7.4
Number of Reviews
198
Ranking in other categories
Software Defined Storage (SDS) (5th), HCI (4th), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (4th)
 

Featured Reviews

Nuno Mendes - PeerSpot reviewer
High performance solution that makes it easy to efficiently manage VM resources
In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).
MahendraPanchotiya - PeerSpot reviewer
Offers a unified platform, reduces downtime, and simple updates
Nutanix offers a unified platform for managing databases, virtual machines, and applications. This simplifies management by consolidating everything into a single interface. While Nutanix may have a higher upfront cost compared to other hypervisors, it can significantly reduce the resources needed for infrastructure management. With our previous hypervisor, we needed nearly ten IT personnel. Nutanix has allowed us to streamline our team to just three members. We use a combination of database technologies, including SQL databases and web servers such as IIS, BHP, and NGINX. Nutanix features helped our organization reduce downtime. I don't recall the last time we had downtime related to Nutanix because it is such a stable product. Nutanix, a reliable product, helps us streamline our processes, which in turn improves company revenue. We began to see the benefits after two years, with a 40 percent reduction in operational costs. We migrated 200 servers from AWS to Nutanix. Nutanix may not consolidate applications, but it helps us run them more efficiently on its platform. Updating is simple with one click. I would rate the updating processes 10 out of 10. Adding compute and storage on demand is not difficult. However, we need to factor in the existing and new firmware and software requirements.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The possibility to share the workload is one of its most valuable features. We have many applications which have need of workloads only a few times in a month, so we share HyperFlex with them."
"The most valuable feature of Cisco HyperFlex HX-Series is the integration with everything in a much smoother, such as in physical and virtual environments. VMware NSX is a simpler solution but, Cisco HyperFlex HX-Series is more robust compared to VMware NSX."
"It's very easy to use and quite a mature product."
"It increases efficiency, decreases the cost, and manages the network in one single way. That's the most important thing."
"The technical support has been very good for this solution."
"Performance-wise, everything is good. So far, we haven't had any issues. There has been no downtime at all."
"The scalability of the product is quite good overall - as long as you plan correctly from the outset."
"Great integration with backup software."
"Nutanix Acropolis AOS is stable. We didn't receive any concerns regarding any problems, The customers have no concerns about the reliability."
"Most beneficial feature is simplicity, ease of use."
"It is less expensive than VMware products. It is also a little bit more flexible, but it really comes down to price for us."
"It is very easy to clone systems using the solution."
"Nutanix has the best virtual desktop infrastructure."
"The most valuable feature is Move, which allows you to migrate virtual machines from VM to AHV."
"Acropolis' main advantages are high performance and availability."
"Acropolis AOS's networking concept is excellent."
 

Cons

"The initial setup can be complex."
"The initial setup can be a bit complex."
"The price could be better. I think it's more expensive than VxRail. In the next release, I would like to see a better level of protection and availability with six clients."
"The architecture separates data, computing, memory, and storage into different parts."
"We would like HyperFlex to connect the storage directly into Fabric Interconnect along with the features of the solution. We have enough ports in HyperFlex. We don't want to buy another set of switches to connect to Fabric Interconnect, complicating the solution."
"We need to be able to scale out and not just up. When you want to scale up or scale out, you are quite limited."
"I haven't been too impressed with the Cisco HyperFlex HX, honestly. It's a hard concept."
"The utilization needs to be better. It needs more options."
"The licenses for Nutanix are very complicated."
"The storage and back-up facilities could be improved. We need day-to-day encrypting of the database."
"We would like to see it support other systems outside of the compute stack from which it was built."
"We could always use a performance upgrade, or simplified management."
"Nutanix can be a bit complex to understand."
"It already has the capability to integrate with the major cloud providers but, in an upcoming release, if there is a possibility to have it integrate with other cloud providers like IBM, Alibaba, and other moderate-level cloud providers, that would be good."
"The product needs improvement in the areas of SAN attachment for high capacity and high I/O profile workloads."
"Benchmark testing indicated that workloads did slightly better on our Vblock by a few percentage"
 

Pricing and Cost Advice

"Initially HyperFlex was a little costly, it was higher, but Cisco wanted to get into our company, so they gave us a fair discount."
"There is a recurring cost for the VMware license and the HyperFlex licenses."
"There is a 30 percent additional premium that all the companies are charging for Cisco HyperFlex HX-Series because of the lack of chips and bottlenecks in the market. The cost of the solution is high right now."
"Pricing is better if you buy more Cisco products."
"We negotiated with Cisco and we got some price benefit from that."
"Cisco is quite expensive, but not in the initial first buy."
"The cost is expensive, but there is a chance to save money in the future."
"Cisco HyperFlex HX-Series is a bit pricier compared to other brands in the market...There is a need to make additional payments towards the maintenance and support of the solution."
"Our licensing fee on the total setup up was about R900 000."
"I know Nutanix and VxRail have similar prices and licenses. Nutanix is a go-ahead if AHV is used as hypervisor because it is already embedded in the price."
"Able to grow with smaller, more linear increments of investment"
"There are a lot of features included with Nutanix that cost a lot with other companies."
"I don't feel that I am receiving the performance which I am paying for."
"In terms of the solution's licensing, it's quite comprehensive."
"The licensing costs are a bit expensive but when you compare the features, it's reasonable."
"The solution could be a little less expensive."
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Comparison Review

it_user244362 - PeerSpot reviewer
Aug 30, 2015
Nutanix vs. VMware EVO:RAIL vs. FlexPod
Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…
 

Answers from the Community

NC
Aug 2, 2022
Aug 2, 2022
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrat...
See 2 answers
Oct 17, 2021
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.
Steffen Hornung - PeerSpot reviewer
Aug 2, 2022
With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.
 

Top Industries

By visitors reading reviews
Computer Software Company
19%
Financial Services Firm
8%
Government
8%
Manufacturing Company
6%
Computer Software Company
18%
Financial Services Firm
8%
Manufacturing Company
8%
Government
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...
How does VxRail compare with Cisco HyperFlex HX Series?
VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...
What is the biggest difference between Nutanix Acropolis and VMware vSphere?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
Which would you choose - Nutanix Acropolis AOS or VMware vSAN?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
What makes Nutanix Cloud Infrastructure (NCI) worth using?
NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...
 

Also Known As

No data available
Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis
 

Overview

 

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest
St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.
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