How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?

What are the pros and cons of each?

Content Manager at PeerSpot (formerly IT Central Station)
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2 Answers
Real User
Top 5
Oct 17, 2021

Cisco HyperFlex HS series vs Nutanix Acropolis AOS

Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis.

We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise.

While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement.

We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features.

Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting.


Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.

Product comparison that may be of interest to you
Steffen Hornung - PeerSpot reviewer
Administrator at Neuberger Gebäudeautomation GmbH
Real User
Top 5Leaderboard
Aug 2, 2022

With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud.

I don’t know Hyperflex at heart, though.

Also, support at Nutanix is outstanding.

Find out what your peers are saying about Cisco HyperFlex HX-Series vs. Nutanix Cloud Infrastructure (NCI) and other solutions. Updated: September 2023.
734,156 professionals have used our research since 2012.
Related Questions
User at gobernación de cundinamarca
May 4, 2023
Hello community,  I am currently researching Hyper-Converged solutions. Which solution performs better: Nutanix Cloud Infrastructure or VMware vSAN? Which solution do you prefer and why? Thank you for your help.
2 out of 4 answers
Yves Sandfort - PeerSpot reviewer
CEO & Majority Shareholder at Comdivision Consulting GmbH
May 2, 2023
In the early days, Nutanix had the better solution, by now especially when you use a vSphere hypervisor I would go with vSAN for better integration and with ReadyNodes no complex config anymore. Also, I had several customers who complained that Nutanix got very expensive on the first renewal vs. massive initial discounts, however, I can't judge if that is true.
Enterprise Solutions Specialist - System Engineer at a tech services company with 501-1,000 employees
May 2, 2023
Both can get you the performance you might want, however, you should also consider what else you get with the solution. For Nutanix, you're stuck on Acropolis if you start with that. It would be best to run either VMware or Hyper-V on top of that so migration isn't a gym show, plus the renewal cost will be very high. vSAN is a fine option, just ensure it is designed well with enough nodes to tolerate any amount of disk failure. Both options have their unique value but the most important thing is the data. You'll need data protection solutions like Veeam, Nakivo, or Zerto.  For an all-in-one high-performance solution with built-in data protection consider HPE SimpliVity with VMware. You'll also likely buy fewer nodes than the others with SimpliVity.
Content Manager at PeerSpot (formerly IT Central Station)
Jan 23, 2023
How would you rate the protection that this product provides for your data?
2 out of 3 answers
Tech blogger
Dec 18, 2022
I think NCI does a pretty good job with security for its users. My organization was using a different solution before NCI, and we had to switch to this one because of pricing issues. We were worried this one might be less good because it was slightly less expensive, but we were proven wrong. It provides multi-cloud security for your applications and data and does that at an enterprise level. You can expect many benefits from it, and benefit from strong firewalls while using simple navigation. This product definitely protects our data and you can rely on it.
Beth Safire - PeerSpot reviewer
Tech Blogger
Dec 18, 2022
Nutanix Cloud Infrastructure is a very secure solution and ensures this through its Flow Network Security feature. The platform establishes a foundation through a Zero Trust strategy that is compatible with regulations and increases your own data's safety. It gives you services like user-centric identity and enhanced malware protection through which your data's safety from malware and malicious attacks is considerably increased. And the best part is you can enable Flow Network Security for free for two months and give it a try. We tried it like this after requesting a personalized demo, and have not disabled it since. If you are looking for a solution that protects both your applications and your company's data - NCI is the way to go.
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