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Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco HyperFlex HX-Series [...
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
90
Ranking in other categories
No ranking in other categories
Nutanix Cloud Infrastructur...
Average Rating
8.6
Reviews Sentiment
7.4
Number of Reviews
197
Ranking in other categories
Software Defined Storage (SDS) (3rd), HCI (3rd), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (5th)
 

Featured Reviews

Nuno Mendes - PeerSpot reviewer
High performance solution that makes it easy to efficiently manage VM resources
In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).
MahendraPanchotiya - PeerSpot reviewer
Offers a unified platform, reduces downtime, and simple updates
Nutanix offers a unified platform for managing databases, virtual machines, and applications. This simplifies management by consolidating everything into a single interface. While Nutanix may have a higher upfront cost compared to other hypervisors, it can significantly reduce the resources needed for infrastructure management. With our previous hypervisor, we needed nearly ten IT personnel. Nutanix has allowed us to streamline our team to just three members. We use a combination of database technologies, including SQL databases and web servers such as IIS, BHP, and NGINX. Nutanix features helped our organization reduce downtime. I don't recall the last time we had downtime related to Nutanix because it is such a stable product. Nutanix, a reliable product, helps us streamline our processes, which in turn improves company revenue. We began to see the benefits after two years, with a 40 percent reduction in operational costs. We migrated 200 servers from AWS to Nutanix. Nutanix may not consolidate applications, but it helps us run them more efficiently on its platform. Updating is simple with one click. I would rate the updating processes 10 out of 10. Adding compute and storage on demand is not difficult. However, we need to factor in the existing and new firmware and software requirements.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cisco HyperFlex is helping us to put everything in centrally so that we can manage in one place."
"The most valuable features of this solution are scalability, performance, and reliability. It scales well inside of a large data center."
"The most valuable feature of Cisco HyperFlex HX-Series is its performance."
"I love the Cisco design, the visual interface to manage and use the platform."
"The solution is stable."
"The feature that we are most interested in is the scalability. When needed, we are able to add more nodes and scale it up further."
"The UCS, which is by far the best management tool there is on the market, regardless of vendor. It's the only tool I see that gives you the opportunity to size and scale all the assets and capacity you have in your data center, from a unified view."
"The initial setup is very straightforward."
"The replication method between Nutanix clusters is a valuable feature."
"The flexibility of this system is very good. It's also faster than others, and has skilled technical support who showed more initiative than a competitor, e.g. VMware."
"Everything is core centralized on the UI."
"Its most valuable feature is simplicity. It is so easy to use. Upgrades are easy. It is easy in terms of disaster recovery, failover, database provisioning, and reporting. Everything about it is just simple."
"This is a very flexible solution that you are able to run however you want."
"The best feature of Nutanix Acropolis AOS is the central management of all of our resources. Additionally, it is easy to use"
"I have found the solution to be stable."
"The most valuable features are its ease of use and its good performance."
 

Cons

"I would like to see them expand onto the cloud."
"It would have been nice if the product provided some cloud integrations."
"I would rate the installation of Cisco HyperFlex HX-Series an eight out of ten. It can be complex."
"I have been receiving a memory overflow message every day when I use the solution."
"Deployment on-prem was quite difficult."
"The solution's price could be affordable."
"There are sometimes issues with memory failure."
"The architecture separates data, computing, memory, and storage into different parts."
"It would be fantastic if there was a built-in layer, in Nutanix, that acted like a cloud interface. So far, we need to integrate a cloud interface on top of Nutanix for billing the usage for specific customers' domains. It would be great if a cloud gateway was built-in, inside Nutanix."
"The reporting feature isn't very good."
"Nutanix has a complex infrastructure, we have customers that consider VMware instead. Additionally, the performance could be better."
"We'd like to have more resource management."
"In the licensing, it needs to be clear about features because it is not clear whether Flow is integrated or not."
"I feel like the flow chart and the automated processes have some room for improvement. They're nearly there, and the rest is fine. They've improved a lot over the past few years."
"Make it easier to manage."
"Nutanix needs to improve network features like Passthrough – SR-IOV. It could be improved by supporting SR-IOV, if they had that support, I would not have needed to implement the VMWare vSAN."
 

Pricing and Cost Advice

"It's roughly $30,000 per Hyperflex license, so that would be about $60,000 a year."
"We would not have invested if we didn't feel the return was there for our customers."
"Cisco is quite expensive, but not in the initial first buy."
"I would like the pricing to be cheaper."
"Our licensing is Hybrid. We have all of our applications for billing and outage management through this."
"We negotiated with Cisco and we got some price benefit from that."
"There is a recurring cost for the VMware license and the HyperFlex licenses."
"We are on an annual subscription and the price is fair."
"It's a bit expensive, but it's worth it."
"It is slightly more expensive compared to a standard, on-prem, bare-metal configuration. There is about a 30 percent overhead there."
"The basic license that comes with the box allows basic virtualization features but advanced automation features would require an upgrade of licenses."
"Pricing varies greatly between license and editions."
"Able to grow with smaller, more linear increments of investment"
"Nutanix Cloud Infrastructure’s pricing is very good and competitive."
"The price of the solution could improve. Nutanix has recently changed its pricing model from perpetual to subscription. They have identified there are challenges with the pricing model."
"The initial cost is affordable but the renewal fees are high."
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Comparison Review

it_user244362 - PeerSpot reviewer
Aug 30, 2015
Nutanix vs. VMware EVO:RAIL vs. FlexPod
Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…
 

Answers from the Community

NC
Aug 2, 2022
Aug 2, 2022
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrat...
See 2 answers
Oct 17, 2021
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.
Steffen Hornung - PeerSpot reviewer
Aug 2, 2022
With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.
 

Top Industries

By visitors reading reviews
Computer Software Company
25%
Financial Services Firm
9%
Government
8%
Manufacturing Company
7%
Educational Organization
38%
Computer Software Company
12%
Financial Services Firm
6%
Manufacturing Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...
How does VxRail compare with Cisco HyperFlex HX Series?
VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...
What is the biggest difference between Nutanix Acropolis and VMware vSphere?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
Which would you choose - Nutanix Acropolis AOS or VMware vSAN?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
What makes Nutanix Cloud Infrastructure (NCI) worth using?
NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...
 

Also Known As

No data available
Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis
 

Overview

 

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest
St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.
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