There are several endpoint protection solutions available that can provide protection for endpoints running on Linux, Windows, and MacOS. Among them are Symantec (Broadcom) Endpoint Protection, Trend Micro Apex One, McAfee (Trellix) Endpoint Security, Kaspersky Endpoint Security for Business, ESET Endpoint Security, Palo Alto Networks Cortex XDR and, perhaps surprisingly (but then again, not) Microsoft Defender for Endpoint. (This is not an exhaustive list).
However, the devil is in the details regarding which versions of an OS and what kind of hardware requirements a given solution supports. You need to closely check the specifics of the range of devices you have with what a given vendor covers. It's also important to note that for agent-based solutions, the minimum processor requirements may allow you to install the product, but if you're just getting by in that regard, there could be issues with computer performance.
Symantec supports a fairly broad range of Linux and Windows Embedded versions, but does not support application control on Mac, Windows Servers, Windows Embedded, Linux, or mobile devices.
Trend Micro Apex One's agents support support from macOS High Sierra 10.13 to macOS Monterey 12, on Apple M1, Apple M2, or Intel® Core processors. To protect Linux file, web, and application servers with Trend Micro, you'll need its ServerProtect product.
McAfee handles Windows 8.1, 10, and 11, and offers limited customer service if you try running it on Windows 8.0 and 7.x. For macOS it goes as far back as Mac OS X 10.10 and through to macOS 12 (Monterey). For Linux it offers limited coverage: Ubuntu 16.04, Ubuntu 18.04, and Ubuntu 20.4.
With Kaspersky Endpoint Security for Business you get Windows, of course, and pretty extensive Linux coverage, with nine 32-bit OSs covered, and literally dozens of 64-bit Linux flavors. Mac coverage is included in the Advanced and Select versions of Kaspersky ESB (and you also get Android and iOS).
ESET Endpoint Security will work with Windows 7 - 11 (although some features are not supported on ARM processors) macOS 10.12 and up, and a couple of 64-bit Linux systems: Ubuntu Desktop 18.04 LTS and RHEL Desktop 7.
PAN Cortex XDR supports Windows 8 - 11 as well as macOS as far back as 10.13 with its 7.5-CE release. Subsequent 7.x releases cover later macOS versions (with 7.7.3 and later handling macOS 13.x). Cortex XDR only supports 64-bit Linux and you have to install a supported kernel module version, but it does cover a good selection of the main Linux offerings including CentOS, Debian, Oracle, RHEL, openSUSE, and Ubuntu.
Microsoft Defender for Endpoint has coverage for macOS 11 (Big Sur), 12 (Monterey), and 13 (Ventura), although Big Sur requires some additional configuration. It also protects more recent versions of RHEL, CentOS, Ubuntu, Debian, and Oracle Linux. Android (6.0 and higher) and iOS (11.0 and higher) are also available.
As for legacy systems, it's best to explicitly ask the vendor if they cover the particular hardware/OSs you have. For example, older versions of Symantec Endpoint Protection 14 cover Windows as far back as Vista, and Windows Server as far back as Windows Server 2008 (RTM, SP1, SP2).
Search for a product comparison in Endpoint Protection Platform (EPP)
Endpoint Protection Platform (EPP) safeguards endpoints by preventing malware, detecting malicious activities, and providing a centralized management system.
Modern EPPs are designed to address the growing threat landscape with features like real-time monitoring, machine learning-based threat detection, and integration with other security tools. They offer comprehensive protection that includes antivirus, anti-malware, and endpoint detection and response capabilities.
What features...
There are several endpoint protection solutions available that can provide protection for endpoints running on Linux, Windows, and MacOS. Among them are Symantec (Broadcom) Endpoint Protection, Trend Micro Apex One, McAfee (Trellix) Endpoint Security, Kaspersky Endpoint Security for Business, ESET Endpoint Security, Palo Alto Networks Cortex XDR and, perhaps surprisingly (but then again, not) Microsoft Defender for Endpoint. (This is not an exhaustive list).
However, the devil is in the details regarding which versions of an OS and what kind of hardware requirements a given solution supports. You need to closely check the specifics of the range of devices you have with what a given vendor covers. It's also important to note that for agent-based solutions, the minimum processor requirements may allow you to install the product, but if you're just getting by in that regard, there could be issues with computer performance.
Symantec supports a fairly broad range of Linux and Windows Embedded versions, but does not support application control on Mac, Windows Servers, Windows Embedded, Linux, or mobile devices.
Trend Micro Apex One's agents support support from macOS High Sierra 10.13 to macOS Monterey 12, on Apple M1, Apple M2, or Intel® Core processors. To protect Linux file, web, and application servers with Trend Micro, you'll need its ServerProtect product.
McAfee handles Windows 8.1, 10, and 11, and offers limited customer service if you try running it on Windows 8.0 and 7.x. For macOS it goes as far back as Mac OS X 10.10 and through to macOS 12 (Monterey). For Linux it offers limited coverage: Ubuntu 16.04, Ubuntu 18.04, and Ubuntu 20.4.
With Kaspersky Endpoint Security for Business you get Windows, of course, and pretty extensive Linux coverage, with nine 32-bit OSs covered, and literally dozens of 64-bit Linux flavors. Mac coverage is included in the Advanced and Select versions of Kaspersky ESB (and you also get Android and iOS).
ESET Endpoint Security will work with Windows 7 - 11 (although some features are not supported on ARM processors) macOS 10.12 and up, and a couple of 64-bit Linux systems: Ubuntu Desktop 18.04 LTS and RHEL Desktop 7.
PAN Cortex XDR supports Windows 8 - 11 as well as macOS as far back as 10.13 with its 7.5-CE release. Subsequent 7.x releases cover later macOS versions (with 7.7.3 and later handling macOS 13.x). Cortex XDR only supports 64-bit Linux and you have to install a supported kernel module version, but it does cover a good selection of the main Linux offerings including CentOS, Debian, Oracle, RHEL, openSUSE, and Ubuntu.
Microsoft Defender for Endpoint has coverage for macOS 11 (Big Sur), 12 (Monterey), and 13 (Ventura), although Big Sur requires some additional configuration. It also protects more recent versions of RHEL, CentOS, Ubuntu, Debian, and Oracle Linux. Android (6.0 and higher) and iOS (11.0 and higher) are also available.
As for legacy systems, it's best to explicitly ask the vendor if they cover the particular hardware/OSs you have. For example, older versions of Symantec Endpoint Protection 14 cover Windows as far back as Vista, and Windows Server as far back as Windows Server 2008 (RTM, SP1, SP2).
Cortex XDR from Paloalto have solution for all three and talking about legacy infrastructure can you name some of them??