What Is The Biggest Difference Between NetApp HCI and Nutanix?

The biggest difference is the ability to scale compute and storage independently. NetApp can scale up the storage without the need for extra CPU (and hence VMware licenses for ESX). Nutanix does have a storage node, but it has limitations. Another key difference is the NetApp uses an inbuilt method for the central storage plane and doesn't use VSAN which saves on licensing. Cost wise, Nutanix is almost always more expensive than alternative solutions.

NetApp is all flash based on SolidFire Storage . support only VMware
but Nutanix can work with VMware , Hyper-V, Nutanix AHV . Also it can be Hybrid Or All Flash.

If your prime consideration is initial cost then Nutanix with it's ability to provide a non-Flash solution is going to be the answer.
The NetApp HCI solution with separate compute and storage nodes enables scaling in either resource type without needing to include the other. This could reduce TCO over a period of time as requirements change. As the storage is non-virtualised more CPU resources are made available to service user workloads. Native connectivity to hyperscalers and design guides for Private Cloud and an expanding hypervisor landscape.

Ahmed Gomaa, I am sorry, but this is plain wrong.

NetApp HCI supports not only VMware, HyperV, and KVM but has also the unique ability to connect physical hosts without performance penalty or license overhead.

The biggest difference in terms of architecture is that Nutanix needs a Controler Virtual Machine on every host, beeing a legacy HCI architecture. NetApp HCI is references as "disaggregated HCI" as compute nodes serve only compute and storage nodes serve only storage. This allows us to scale compute and storage independently, so no HCI tax wasted.

THE biggest difference in terms of performance is that IOPs are guaranteed in the storage subsystem of NetApp HCI. This is a game-changer for a datacenter as it enables private cloud admins to guarantee SLAs - not just bet on them.

For small environments without the need for VMware Nutanix may be a good choice. But data locality (data needs to reside on the hosts it is read from (kills this solution in my perspective for larger deployments). Even with a prism - making the administration of multiple Nutanix clusters nice and shiny - there are still several clusters in place. With NetApp, HCI there is no need for this. You can consolidate workloads on a massive scale.

The biggest difference in terms of hybrid multi-cloud is that NetApp HCI can speak natively with ONTAP systems via SnapMirror and it integrates directly into all hyperscalers. Ultimately the management of containers can be done within one pane of glass - regardless of where the containers live - OnPrem on HCI, GCS, AWS, Azure.

For me the HCI market is like the automotive market 60 years ago: Germans invented the car, but US-made is cool. Nutanix "invented" HCI, but NetApp wtook it that one step further.

NetApp are enables to NetApp's customers (Already customers) to reuse their legacy hardware while moving the legacy hardware to DR and using SnapMirror techonology for replication while they will use at Primary site using NetApp HCI . It's reducing to need to buy solution for two sites

In the other hand , Nutanix have solutions based Hybrid, those are reduce costs , not every customer is need an All flash solution.
Also , in Nutanix the customer can choose with which hypervisor the would like to run their environment (AHV , VMWARE KVM , Hyper-V etc..)

Wihout any doubt go for nutanix HCI

My only difference is that Nutanix was still developing features with their software BUT what was there fir what we were accessing was very good. I cannot comment on cost as everyone uses their own vendor pools. You need to test both interfaces in your environment or in the vendors test environment and determine if the solution overall will fit your Architecture and Growth plans.
Don't forget the learning curve to adapt and the ongoing maintenance costs. Finally Support... call into the support line and see if their response or professionalism with will for you.
Nothing worse than calling for support and it the company has 9-5 offering lol.

it depends on your needs
NetApp Is Very Good , but expensive as it's All Flash , based on SolidFire Storage . It will support only VMware
but Nutanix can be ALL Flash or Hybrid , also can work with Hyper-v , VMware or Nutanix AHV