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Microsoft Defender for Endpoint vs Proofpoint Email Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.9
Microsoft Defender for Endpoint offers significant ROI with cost savings, seamless integration, and real-time protection against ransomware attacks.
Sentiment score
6.5
Proofpoint Email Protection effectively reduced threats and costs, excelling in phishing defense, leading to significant efficiency improvements.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
Consultant at ACT4SERVICES
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
IT CONSULTANT at a tech company with 10,001+ employees
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
Lead security engineer at a computer software company with 11-50 employees
 

Customer Service

Sentiment score
6.4
Many users find Microsoft Defender for Endpoint reliable, but support experiences vary, with premium support offering quicker assistance.
Sentiment score
7.1
Proofpoint Email Protection's customer service is praised for responsiveness and expertise, though some report slow responses or portal issues.
The Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, 'Just to set expectations, my lunch break is in an hour and I am going to go away then.'
Security Analyst III at a healthcare company with 10,001+ employees
The level-one support seems disconnected from subject matter experts.
Office 365 Subject Expert at a government with 10,001+ employees
I rate Microsoft support 10 out of 10.
Team manager of it department at a financial services firm with 501-1,000 employees
I am familiar with the granular policy control feature of Proofpoint Email Protection, and I find their support excellent for modifying those policies.
Senior Cybersecurity Specialist at a retailer with 10,001+ employees
 

Scalability Issues

Sentiment score
7.4
Microsoft Defender for Endpoint is scalable and integrates well with Microsoft’s ecosystem, despite needing improvements for handling massive data.
Sentiment score
7.5
Proofpoint Email Protection excels in adaptability and scalability, serving both small and large enterprises with ease and flexibility.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Compatibility is its main feature.
IT CONSULTANT at a tech company with 10,001+ employees
Proofpoint is scalable for multi-site organizations with thousands of users.
Products and solutions director at ITVikings
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is praised for its reliability and stability, with minor concerns about resource intensity and performance.
Sentiment score
8.2
Users rate Proofpoint Email Protection highly for reliability and performance, with minor UI challenges and rare stability issues.
I haven't seen any outages with Microsoft.
IT Security Engineer at a financial services firm with 1,001-5,000 employees
I rate Defender 10 out of 10 for stability.
Team manager of it department at a financial services firm with 501-1,000 employees
Defender for Endpoint is extremely stable.
Systems engineers at Delta Dental of Colorado
 

Room For Improvement

Microsoft Defender for Endpoint faces interface complexity, slow detection, high CPU usage, integration issues, and seeks improvements in multiple areas.
Proofpoint Email Protection struggles with setup complexity, feature enhancements, pricing issues, and requires improved support and interface design.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
Office 365 Subject Expert at a government with 10,001+ employees
In contrast, competing products offer reduced pricing for long-term commitments, which makes it difficult for us in that environment.
Solution Consultant at BIM Group of Companies
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Team manager of it department at a financial services firm with 501-1,000 employees
Proofpoint could expand its phishing detection capabilities to improve its efficiency.
Products and solutions director at ITVikings
More security could be implemented.
Logistics Manager at a educational organization with 501-1,000 employees
I may advise Proofpoint to adjust marketing solutions based on each country.
Manager, IT Director at Cakmak Avukatlik Ortakligi
 

Setup Cost

Microsoft Defender for Endpoint offers flexible pricing, making it competitive and cost-effective compared to standalone security products.
Proofpoint Email Protection is considered costly, with pricing starting at $8 per user and varying by features.
That has been the trend we have seen with Microsoft lately—it is just getting more and more expensive.
Assistant Director, Hybrid Infrastructure & Operations at a insurance company with 501-1,000 employees
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
Team manager of it department at a financial services firm with 501-1,000 employees
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Customers pay around $90,000 yearly for a 1,000-user organization, with the subscription license being the main expense, apart from implementation fees.
Products and solutions director at ITVikings
Additional costs do come in, but it enhances security.
Logistics Manager at a educational organization with 501-1,000 employees
 

Valuable Features

Microsoft Defender for Endpoint excels with seamless integration, advanced threat intelligence, AI-driven protection, and continuous cloud-based security management.
Proofpoint Email Protection offers advanced threat defense, user-friendly interface, and seamless Office 365 integration for comprehensive email security.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
Snr. Infrastructure Architect (Data Centre) at LogicEra
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
Consultant at ACT4SERVICES
The main feature I find most effective is that Proofpoint Email Protection scans emails and quarantines the doubtful ones.
Logistics Manager at a educational organization with 501-1,000 employees
The most beneficial feature of Proofpoint Email Protection is mostly spam filtering; it was very efficient, and we were very happy with the functionality as only relevant emails were allowed for mailboxes.
Manager, IT Director at Cakmak Avukatlik Ortakligi
I appreciate that it's the industry leader, and its firewalling is very easy to manage and implement.
Senior Cybersecurity Specialist at a retailer with 10,001+ employees
 

Categories and Ranking

Microsoft Defender for Endp...
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
210
Ranking in other categories
Endpoint Protection Platform (EPP) (2nd), Advanced Threat Protection (ATP) (3rd), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (2nd), Microsoft Security Suite (3rd)
Proofpoint Email Protection
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
53
Ranking in other categories
Email Security (3rd), Digital Risk Protection (3rd), Office 365 Protection (2nd), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of January 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 6.4%, down from 7.7% compared to the previous year. The mindshare of Proofpoint Email Protection is 7.1%, down from 12.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Endpoint6.4%
Proofpoint Email Protection7.1%
Other86.5%
Advanced Threat Protection (ATP)
 

Featured Reviews

Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.
reviewer2500410 - PeerSpot reviewer
Senior Cybersecurity Specialist at a retailer with 10,001+ employees
Has provided reliable threat detection and simplified policy management
I do not have experience with Microsoft Purview products, but I know some Proofpoint products. I apologize, I do not have experience with the Purview one, but I do know the Proofpoint products. I'm not sure about the features of the Purview one. Compared to other products, Proofpoint's real-time threat intelligence makes it less noisy. They collect and share threat information effectively, which benefits all customers. I have seen a lot of improvements in Proofpoint's reporting and analytics compared to earlier days. As a leader in the market, I find the pricing for Proofpoint Email Protection is a little high. Their licensing models vary, and even the premium model adequately supports awareness campaigning, so I find it acceptable. Normally, they sell their products through resellers, not directly through AWS Marketplace. For us, we are clients of Proofpoint. I rate Proofpoint Email Protection a nine out of ten.
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879,422 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
12%
Manufacturing Company
9%
Financial Services Firm
8%
Government
8%
Computer Software Company
12%
Financial Services Firm
11%
Manufacturing Company
8%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business80
Midsize Enterprise40
Large Enterprise92
By reviewers
Company SizeCount
Small Business21
Midsize Enterprise13
Large Enterprise17
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
What is your experience regarding pricing and costs for Proofpoint Email Protection?
In terms of pricing, it is okay compared to others. I would say it is normal. Additional costs do come in, but it enhances security.
What needs improvement with Proofpoint Email Protection?
I believe they still need to improve by consolidating some portals, as currently, you have to log in separately to a few of them.
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
Proofpoint Enterprise Protection, Proofpoint Digital Protection
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Blocket, University of Waterloo, Lincoln Memorial University, WellSpan Health, U-Haul, Carestream Health, Westinghouse
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Proofpoint Email Protection and other solutions. Updated: December 2025.
879,422 professionals have used our research since 2012.