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Microsoft Defender for Endpoint vs Proofpoint Email Protection comparison

 

Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.9
Organizations report financial and operational benefits from Microsoft Defender for Endpoint, including improved security, automation, and cost reduction.
Sentiment score
5.0
Proofpoint Email Protection enhances efficiency and threat defense, reducing security incidents and manual workload despite its cost.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
Consultant at ACT4SERVICES
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
IT CONSULTANT at a tech company with 10,001+ employees
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
Lead security engineer at a computer software company with 11-50 employees
The ideal situation would be to have all these portals combined into one unified dashboard.
Information Security Architect at Loews Hotels
After Proofpoint Email Protection, phishing has been completely eliminated, so it is working very efficiently.
Security Engineer at News Corp
Instead of individually logging into five portals, we can log into one and they all connect as if we had logged into all of them.
SOC at a financial services firm with 201-500 employees
 

Customer Service

Sentiment score
6.3
Microsoft support is praised for responsiveness and knowledge, but varies in quality; documentation and complex issue resolution need improvement.
Sentiment score
7.2
Proofpoint Email Protection support is generally reliable but requires improvements in communication and direct engagement for better satisfaction.
The Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, 'Just to set expectations, my lunch break is in an hour and I am going to go away then.'
Security Analyst III at a healthcare company with 10,001+ employees
The level-one support seems disconnected from subject matter experts.
Office 365 Subject Expert at a government with 10,001+ employees
I rate Microsoft support 10 out of 10.
Team manager of it department at a financial services firm with 501-1,000 employees
I am familiar with the granular policy control feature of Proofpoint Email Protection, and I find their support excellent for modifying those policies.
Senior Cybersecurity Specialist at a retailer with 10,001+ employees
Even the engineers have been helpful, and if we open a case, they get back to us right away.
Information Security Analyst at a government with 11-50 employees
We always contact them if we need support, whether it's for setting up features or technical support, which is very responsive.
System Administrator at Tutt Bryant Group
 

Scalability Issues

Sentiment score
7.4
Microsoft Defender for Endpoint is scalable, seamlessly accommodating large environments with flexible deployment and integration with Microsoft's ecosystem.
Sentiment score
7.3
Proofpoint Email Protection is scalable and flexible for enterprises, though some face costs and integration challenges.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Compatibility is its main feature.
IT CONSULTANT at a tech company with 10,001+ employees
Proofpoint is scalable for multi-site organizations with thousands of users.
Products and solutions director at ITVikings
The solution provides a graphical representation and dashboard view showing how many threats are getting blocked on a daily and monthly basis.
Information Technology Team Lead at a manufacturing company with 1,001-5,000 employees
Proofpoint Email Protection is considered to be highly scalable, designed for large enterprises, with a cloud-based architecture that offers an enormous number of options, including multi-organization support and high-volume email handling.
Senior Solution Delivery Lead Cybersecurity at International Olympic Committee – IOC
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is reliable and efficient, with minor update issues, praised for integration and performance.
Sentiment score
8.2
Proofpoint Email Protection is highly regarded for stability, handling high volumes with minimal downtime, ensuring reliable enterprise-level security.
I haven't seen any outages with Microsoft.
IT Security Engineer at a financial services firm with 1,001-5,000 employees
I rate Defender 10 out of 10 for stability.
Team manager of it department at a financial services firm with 501-1,000 employees
Defender for Endpoint is extremely stable.
Systems engineers at Delta Dental of Colorado
If Proofpoint Email Protection has an outage, we are either not receiving emails or not blocking the right threats.
Senior Security Engineer at Cloudflare
Regarding the stability and performance of Proofpoint Email Protection, I have not experienced any crashes, downtimes, or performance issues.
Cyber Security Engineer at a financial services firm with 10,001+ employees
Proofpoint Email Protection is very stable and reliable, as it remains accessible at all times without issues, ensuring that data is available in real time.
Principal Consultant at Infosys
 

Room For Improvement

Microsoft Defender users seek better AI integration, customer support, UI, security, customization, visibility, threat response, and simpler pricing.
Proofpoint Email Protection requires interface improvements, AI enhancements, pricing adjustments, better integration, and responsive support for an improved user experience.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
Office 365 Subject Expert at a government with 10,001+ employees
In contrast, competing products offer reduced pricing for long-term commitments, which makes it difficult for us in that environment.
Solution Consultant at BIM Group of Companies
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Team manager of it department at a financial services firm with 501-1,000 employees
The older legacy user interface just took a little to work with, and the new unified interface, as it was able to do more and more of the functionality of the old one, the product just got easier and easier to use.
Sr Security Engineer at a comms service provider with 201-500 employees
In addition to the UI improvements, I would appreciate an increase in the speed of the tasks being processed on the pod.
Security Specialist at a leisure / travel company with 10,001+ employees
There are pros and cons to that, but I would suggest maintaining a good balance between security protection and operational impact.
Senior Security Engineer at Cloudflare
 

Setup Cost

Microsoft Defender for Endpoint offers flexible licensing, integrating with Microsoft 365, providing cost-effective, feature-rich enterprise security solutions.
Proofpoint Email Protection is a premium, costly solution valued for its advanced threat protection and comprehensive security benefits.
That has been the trend we have seen with Microsoft lately—it is just getting more and more expensive.
Assistant Director, Hybrid Infrastructure & Operations at a insurance company with 501-1,000 employees
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
Team manager of it department at a financial services firm with 501-1,000 employees
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Customers pay around $90,000 yearly for a 1,000-user organization, with the subscription license being the main expense, apart from implementation fees.
Products and solutions director at ITVikings
Given my other experience with other vendors, I think they are a bit on the high end and a bit on the pricey end for the email security functionality that we were using.
Sr Security Engineer at a comms service provider with 201-500 employees
Although it is a bit costly compared to Mimecast, Defender, and Cofense Vision, it is efficient and strong in security, so I do not mind the cost because I will not reduce my security risk.
Senior Solution Delivery Lead Cybersecurity at International Olympic Committee – IOC
 

Valuable Features

Microsoft Defender for Endpoint offers seamless integration and advanced threat protection with centralized management and low resource usage for enterprises.
Proofpoint Email Protection offers advanced threat detection, enhances security, and integrates with SIEM tools to prevent email-based risks.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Team manager of it department at a financial services firm with 501-1,000 employees
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
Snr. Infrastructure Architect (Data Centre) at LogicEra
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
Consultant at ACT4SERVICES
Without Proofpoint Email Protection, most of these emails would have come through, slipped through Exchange, gotten into the user's mailbox, and created a lot of trouble for the organization.
Cyber Security Engineer at IT Naturally
Proofpoint Email Protection has positively impacted my organization by ensuring we are not at risk of a breach through email.
Release lead at a financial services firm with 10,001+ employees
TAP alerts, where Proofpoint Email Protection scans emails and sends alerts, provide the ability to review suspicious emails and validate them in a sandbox environment.
Infrastructure Analyst at a consultancy with 51-200 employees
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
5th
Average Rating
8.2
Reviews Sentiment
7.0
Number of Reviews
212
Ranking in other categories
Endpoint Protection Platform (EPP) (1st), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (3rd)
Proofpoint Email Protection
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.7
Number of Reviews
106
Ranking in other categories
Email Security (1st), Digital Risk Protection (3rd), Office 365 Protection (1st), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of July 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 5.8%, down from 7.6% compared to the previous year. The mindshare of Proofpoint Email Protection is 3.5%, down from 11.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
Proofpoint Email Protection3.5%
Microsoft Defender for Endpoint5.8%
Other90.7%
Advanced Threat Protection (ATP)
 

Featured Reviews

Robert Arbuckle - PeerSpot reviewer
Security Analyst III at a healthcare company with 10,001+ employees
Automatically isolates threats and integrates with logging to reduce response time
Overall, I would evaluate the Microsoft support level that I receive at probably about a seven, but that depends on the day. It has been spotty. We have had issues where the urgency level of the Microsoft support is not as high as ours, especially during a data breach or potential data breach situation. We have had issues with some of the offshore support being lackluster. One specific thing that comes to mind is we were on a support call with our CISO on the call, and the Microsoft agent, who did not actually work for Microsoft, is one of the vendors that Microsoft uses for support, said, "Just to set expectations, my lunch break is in an hour and I am going to go away then." For us, it was already ten o'clock at night and we had been working on this for a couple of hours, trying to get a security engineer on with us. For him to tell us that he was going to go away and have lunch, it was, "Okay, but go find somebody else if you need to." It was just the lackluster approach, and it seemed like he did not really care. We seem to get a lot of this when we get non-Microsoft support. I can identify areas for improvement with Microsoft Defender for Endpoint, as it is kind of a convoluted mess to try to take care of false positives. Especially when they have been identified as false positives but they keep going off over and over again. It is great for my pocketbook because it generates a lot of on-call action, but I would really prefer more sleep at two o'clock in the morning than dealing with false positives. I would say that the unified portal for managing Microsoft Defender for Endpoint is suitable for both teams as they are all in there. It would be great if they would stop moving things around and renaming things, which makes sense. The new XDR portal is pretty nice. Being able to have it central again inside of the regular Security Center without having to open up two windows is helpful. Overall, I think it is pretty good. There is always going to be something that could be improved, such as alerting and the ability to modify alerts would be a little bit helpful to have. Being able to add more data into the alerts and turn off alerts that are not as useful would be beneficial. It is hard to say what the quantitative impact the security exposure management feature has had on our company's security, because a lot of it is kind of subjective. I think we are sitting at around a fifty percent score still, and a lot of it is just kind of unusual circumstances that we cannot really implement without breaking the organization.
Siva_Prasad - PeerSpot reviewer
Principal Consultant at Infosys
Email defenses have reduced phishing incidents and protect sensitive data across our enterprise
As things are evolving and threats develop in unpredictable ways, Proofpoint must adopt AI solutions and agentic solutions more aggressively and provide them to customers as part of service offerings. Inbuilt AI solutions would add more value and make Proofpoint a more premium choice for customers. With the help of AI solutions, agentic AI, and generative AI capabilities, the product would be more efficient than it currently is. Filtering false positives is highly challenging because it is impossible for humans to identify which emails are genuine and which are spam. Proofpoint should focus more on this area with back-end agents or other tools. Proofpoint should decide which emails are genuine and which are spam so it is not a challenge for end users. When receiving an email, end users should not have to determine whether to respond or not. Proofpoint should not release such spam emails and should strictly block such spam and spoof emails based on connection IPs. Currently, false positives occur in the product, and while this occurs in every product, it is an area where Proofpoint can focus on improving and reducing false positives. One email is enough for an end user to be deceived and lose money, so addressing this area is critical.
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Top Industries

By visitors reading reviews
Manufacturing Company
10%
Financial Services Firm
10%
Computer Software Company
9%
Comms Service Provider
8%
Financial Services Firm
13%
Manufacturing Company
10%
Computer Software Company
7%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business82
Midsize Enterprise45
Large Enterprise96
By reviewers
Company SizeCount
Small Business28
Midsize Enterprise24
Large Enterprise59
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
What is your experience regarding pricing and costs for Proofpoint Email Protection?
I am not informed about the pricing, setup costs, or licensing as it is handled by a different team. I come from a technical perspective.
What needs improvement with Proofpoint Email Protection?
For improvement, the dashboard of Proofpoint Email Protection needs some enhancement. Currently, we are using multiple dashboards, and it would be beneficial if everything was integrated. A single ...
What is your primary use case for Proofpoint Email Protection?
In our environment, we are using Proofpoint Email Protection for inbound email protection as a primary gateway, while Microsoft 365 serves as the secondary gateway. In the primary gateway, it scans...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
Proofpoint Enterprise Protection, Proofpoint Digital Protection
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Blocket, University of Waterloo, Lincoln Memorial University, WellSpan Health, U-Haul, Carestream Health, Westinghouse
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Proofpoint Email Protection and other solutions. Updated: June 2026.
902,894 professionals have used our research since 2012.