Executive SummaryUpdated on Oct 5, 2025
Microsoft Defender for Business and ThreatLocker Zero Trust Endpoint Protection Platform both compete in the business security category. Microsoft Defender generally has an edge in integration within the Microsoft ecosystem, making it a robust choice for environments reliant on Microsoft platforms, while ThreatLocker is preferred for its precise application control and comprehensive security features.
Features: Microsoft Defender offers seamless integration with the Microsoft ecosystem, robust threat detection and response, and extensive vulnerability management. It's noted for its ease of configuration and cost-effectiveness. ThreatLocker distinguishes itself with detailed application control, robust allowlisting, and ring-fencing. Its user-friendly administration and support systems provide detailed access controls and security enhancements.
Room for Improvement: Microsoft Defender users seek better reporting, enhanced DLP, and improved integration with non-Microsoft environments. There's also a need for more precise threat detection and enhanced proactive response. ThreatLocker users desire a more intuitive interface, better PSA system integration, and more visible support. Additionally, some find the learning curve steep, pointing to a need for enhanced support options.
Ease of Deployment and Customer Service: Microsoft Defender is compatible with various environments, including public, hybrid, and on-premises clouds, although users experience challenges with technical support response times. ThreatLocker provides deployment across similar environments, offering personalized support and quicker resolution, which enhances user experience with more responsive and user-oriented service.
Pricing and ROI: Microsoft Defender is bundled with Microsoft 365, reducing operational costs through feature consolidation but seen as expensive by some, with difficult-to-quantify ROI. ThreatLocker, regarded as reasonably priced, offers flexible pricing structures for MSPs and delivers a good security value, aiding cost savings and operational efficiency gains. Its pricing is attractive for organizations needing detailed application governance.
