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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection comparison

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Comparison Buyer's Guide

Executive Summary

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
3rd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (2nd), Email Security (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
33rd
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of November 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 5.8%, down from 12.4% compared to the previous year. The mindshare of Proofpoint Targeted Attack Protection is 1.3%, up from 1.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.8%
Proofpoint Targeted Attack Protection1.3%
Other92.9%
Advanced Threat Protection (ATP)
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
KC
Information Security Specialist at Methanex Chile SpA
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"One of our clients didn't have the budget to invest in a SOC team, but we deployed the solution for them, and they now run a SOC with only one analyst."
"The solution is very easy to use. All you have to do is to assign the license to the end-user and it's done. The customer will only have the feature activated, and the solution will monitor the emails to determine if they are a threat or not."
"Does a thorough job of examining email and URLs for malicious content."
"The good part is that you don't have to configure it, which is very convenient."
"It has helped us in improving our security posture; it detects any kind of attack or abnormal behavior in accessing the system and sends an alert to the administrator who can check, understand, and review on time to ensure that all activities are legit."
"Technical support is very good. They are knowledgeable and respond quickly."
"The risk level notifications are most valuable. We get to know what kind of intrusion or attack is there, and we can fix a problem on time."
"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."
"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
"Proofpoint's major module is email protection, and most of the spam emails that have been directed towards our organization have been locked by Proofpoint, so we have escaped from threat hunters."
 

Cons

"One area for improvement is support, in terms of being able to reach them and, especially, technical support for configuration."
"They have moved features from one console to another. Things have been moved around in the interface and it takes me time to find where certain features are."
"I was looking for some advanced features, like if I would receive an email that contains a legitimate file type, but the content is malicious, how I can protect against that?"
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"Sometimes I have to recategorize things when it takes the wrong step and I do not want it to classify something as suspicious."
"The GUI is sometimes slow to fetch the device report and could be improved."
"To improve Microsoft Defender for Office 365, it would be nice to have more accessibility for users to see on their end what they are doing that could cause a threat."
"The XDR dashboard has room for improvement."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
"We are using the TRAP console that has a Linux-based UI, which is not user-friendly."
 

Pricing and Cost Advice

"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"The product is very expensive."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"The pricing has become expensive."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
Information not available
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Top Industries

By visitors reading reviews
Computer Software Company
11%
Manufacturing Company
10%
Financial Services Firm
8%
Comms Service Provider
7%
No data available
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
No data available
 

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
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Also Known As

MS Defender for Office 365
Targeted Attack Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Brinker Capital
Find out what your peers are saying about Palo Alto Networks, Trellix, Microsoft and others in Advanced Threat Protection (ATP). Updated: October 2026.
921,523 professionals have used our research since 2012.