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Cisco Secure Email vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Feb 8, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.1
Cisco Secure Email is valued for security and efficiency, though financial benefits are mixed and hard to quantify.
Sentiment score
7.1
Microsoft Defender for Office 365 boosts efficiency, cuts phishing, integrates security, reduces tool costs, and mitigates risk.
It has also decreased our time to detection and response by about 15 to 20 percent.
Technology support manager at Alfred State College
Overall, cost of owning and operating our system goes down.
Designation Chief Consultant at Avtow
It's hard to quantify the return on investment we've seen from Microsoft Defender for Office 365.
Chief Architect at a tech vendor with 1,001-5,000 employees
 

Customer Service

Sentiment score
7.3
Cisco Secure Email's superior customer service, marked by prompt, reliable support, is rated highly over competitors like Fortinet.
Sentiment score
5.7
Microsoft Defender for Office 365 support is reliable but varies with subscription level and complexity of issues.
Regarding my interaction with the technical support of Cisco Secure Email, it was zero downtime for the mail production.
Technical Associate Network Security at Valuepoint Systems
Cisco's tech support can be hit or miss, depending on the engineer you get.
Cloud Partner & Solutions Architect at a tech vendor with 1,001-5,000 employees
The support is pretty decent, with a rating of eight out of ten.
Chief Information Security Officer at Abcl
Over the past two years, there have been no critical problems.
Solution Consultant at BIM Group of Companies
we opened tickets, and they typically resolve them quickly.
Chief Architect at a tech vendor with 1,001-5,000 employees
With a subscription for Microsoft Defender for Office 365, it is an eight. Without it, it is a six.
Manager at a tech services company with 10,001+ employees
 

Scalability Issues

Sentiment score
7.3
Cisco Secure Email provides flexible scalability and security enhancements, supporting large setups with positive user experiences and expansion options.
Sentiment score
7.8
Microsoft Defender for Office 365 efficiently scales with cloud-native design, ensuring reliable performance and seamless integration for diverse organizations.
The on-premises hardware is not very scalable, but switching to the SaaS offering is expected to improve scalability.
Chief Information Security Officer at Abcl
My thoughts on the scalability level of Cisco Secure Email is nine because of the delay in making a configuration and the slowness in the console.
Technical Associate Network Security at Valuepoint Systems
We have never faced scalability problems, and Microsoft manages it effectively.
Solution Consultant at BIM Group of Companies
Microsoft Defender for Office 365 scales transparently for us, as we grew from 1,000 users to 3,000 users, and we didn't notice much difference.
Chief Architect at a tech vendor with 1,001-5,000 employees
Microsoft Defender for Office 365 scales with the growing needs of my company well.
Senior Client Director and Advisory Service Leader at Crossfuze
 

Stability Issues

Sentiment score
8.0
Cisco Secure Email is valued for stability and reliability, with minimal issues and efficient operation, requiring minimal maintenance.
Sentiment score
7.8
Microsoft Defender for Office 365 offers consistently reliable performance with minimal downtime, high user ratings, and manageable minor issues.
Based on my experience, the stability of Cisco Secure Email is very strong.
Systems Engineer at a non-tech company with 51-200 employees
I would rate the stability of Microsoft Defender for Office 365 as 10 over 10 because it's highly available, it works, and it does the job it is meant to do.
Cloud Solutions Architect at a tech services company with 201-500 employees
I have not experienced any downtime, crashes, or performance issues because of Defender.
Technology Associate at a financial services firm with 51-200 employees
The solution is stable, as we have been using it for the past two years.
Solution Consultant at BIM Group of Companies
 

Room For Improvement

Cisco Secure Email faces complex UI, integration issues, high costs, and lacks advanced features, affecting usability and scalability.
Microsoft Defender for Office 365 needs improvements in usability, false positive reduction, phishing detection, scalability, and reporting capabilities.
The solution should better analyze the actual content rather than only focusing on the email header or origin.
Chief Information Security Officer at Abcl
It would be beneficial to have the functionality of the Email Threat Defense integrated into the Email Security Gateway so customers don't have to buy two products for full email protection.
Systems Engineer at a non-tech company with 51-200 employees
It may take nearly an hour to get back to normal while configuring policies.
Technical Associate Network Security at Valuepoint Systems
The main area for improvement is simplifying the implementation and rollout process.
Infrastructure and Security Lead at Vedanta
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
Solution Consultant at BIM Group of Companies
There is a different console for different things; I just want one consolidated console.
Senior Director, Security Architecture & Engineering at a leisure / travel company with 10,001+ employees
 

Setup Cost

Cisco Secure Email is costly yet valued for features, with variable pricing based on factors like environment and user count.
Microsoft Defender for Office 365 is cost-effective with E5, costly standalone, requiring careful planning for subscription-based licensing.
Its cost is bundled with other Cisco products.
Chief Information Security Officer at Abcl
The licensing is a mess and needs sorting out.
Cloud Partner & Solutions Architect at a tech vendor with 1,001-5,000 employees
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
Systems Engineer at a non-tech company with 51-200 employees
We've likely saved 30% of costs.
Designation Chief Consultant at Avtow
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Infrastructure and Security Lead at Vedanta
Microsoft is quite affordable with a lot of features available for any size organization.
Solution Consultant at BIM Group of Companies
 

Valuable Features

Cisco Secure Email offers advanced protection, integration, and user-friendly management, enhancing security against malware, spam, phishing, and ransomware.
Microsoft Defender for Office 365 enhances security with AI-driven phishing detection and robust protection across Microsoft 365 services.
It also possesses multiple modules for spam detection, malware detection, and threat intelligence, which are valuable in categorizing emails and determining actions.
Chief Information Security Officer at Abcl
It is highly effective in catching phishing and spam emails.
Systems Engineer at a non-tech company with 51-200 employees
The integration of Cisco AMP for Advanced Malware Protection with Cisco Secure Email has helped our organization's security posture.
Technical Associate Network Security at Valuepoint Systems
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
Technology support manager at Alfred State College
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
Solution Consultant at BIM Group of Companies
The value of the DLP feature is significant to us because we have internal data, sometimes sensitive, and the users may not always be aware of security and privacy, which might lead them to send out information mistakenly to external parties.
Chief Architect at a tech vendor with 1,001-5,000 employees
 

Categories and Ranking

Cisco Secure Email
Ranking in Email Security
6th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
63
Ranking in other categories
Cisco Security Portfolio (9th)
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of August 2026, in the Email Security category, the mindshare of Cisco Secure Email is 4.4%, down from 5.5% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 5.7%, down from 11.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3655.7%
Cisco Secure Email4.4%
Other89.9%
Email Security
 

Featured Reviews

KS
Technical Associate Network Security at Valuepoint Systems
Email security has protected financial data and provides clear tracking for every branch message
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it was a database error or something, but we feel some slowness in configuring DLP and other content filters compared to other consoles. It may have been due to on-premises, but it was much noisy at some times while configuring DLP. When we tried to configure a DLP policy, the console became much slower. In that case, we cannot see what had happened in the mail which was blocked at that time. It may take nearly an hour to get back to normal while configuring policies. That is the major issue in the product.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
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909,725 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Financial Services Firm
11%
Manufacturing Company
9%
Outsourcing Company
7%
Computer Software Company
7%
Computer Software Company
11%
Manufacturing Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business22
Midsize Enterprise18
Large Enterprise27
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
 

Questions from the Community

What is your experience regarding pricing and costs for Cisco Secure Email?
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
What needs improvement with Cisco Secure Email?
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it was a database error or something, but we feel some slowness in configuring DLP ...
What is your primary use case for Cisco Secure Email?
We are using Cisco Secure Email to monitor the outgoing and incoming mail traffic in our financial institute. We have nearly 900 branches all over India. We have an on-premises mail server in which...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cisco Email Security, IronPort, Cisco Email Security, ESA, Email Security Appliances
MS Defender for Office 365
 

Overview

 

Sample Customers

SUNY Old Westbury, CoxHealth, City of Fullerton, Indra
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email vs. Microsoft Defender for Office 365 and other solutions. Updated: August 2026.
909,725 professionals have used our research since 2012.