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Cisco Secure Email vs Microsoft Defender for Office 365 comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Nov 2, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.4
Cisco Secure Email enhances ROI with robust security, reducing disruptions and downtime from cyber threats, despite perceived high costs.
Sentiment score
6.9
Microsoft Defender for Office 365 offers strong ROI through security enhancements, cost savings, and improved company productivity despite measurement challenges.
It has also decreased our time to detection and response by about 15 to 20 percent.
Technology support manager at Alfred State College
Overall, cost of owning and operating our system goes down.
Designation Chief Consultant at Avtow
It's hard to quantify the return on investment we've seen from Microsoft Defender for Office 365.
Chief Architect at a tech vendor with 1,001-5,000 employees
 

Customer Service

Sentiment score
7.3
Cisco Secure Email support is praised for its responsiveness and expertise, though experiences can vary based on assigned engineers.
Sentiment score
5.8
Microsoft Defender for Office 365 users rate support highly, praising its responsiveness and 24/7 availability, despite occasional documentation and communication issues.
Cisco's tech support can be hit or miss, depending on the engineer you get.
Cloud Partner & Solutions Architect at a tech vendor with 1,001-5,000 employees
The support is pretty decent, with a rating of eight out of ten.
Chief Information Security Officer at Abcl
Over the past two years, there have been no critical problems.
Solution Consultant at BIM Group of Companies
we opened tickets, and they typically resolve them quickly.
Chief Architect at a tech vendor with 1,001-5,000 employees
With a subscription for Microsoft Defender for Office 365, it is an eight. Without it, it is a six.
Manager at a tech services company with 10,001+ employees
 

Scalability Issues

Sentiment score
7.2
Cisco Secure Email provides scalable solutions for seamless user migration and system growth, with reliable cloud service options.
Sentiment score
7.8
Microsoft Defender for Office 365 offers scalable, efficient protection for large enterprises, ensuring seamless growth across diverse industries.
The on-premises hardware is not very scalable, but switching to the SaaS offering is expected to improve scalability.
Chief Information Security Officer at Abcl
We have never faced scalability problems, and Microsoft manages it effectively.
Solution Consultant at BIM Group of Companies
Microsoft Defender for Office 365 scales transparently for us, as we grew from 1,000 users to 3,000 users, and we didn't notice much difference.
Chief Architect at a tech vendor with 1,001-5,000 employees
Microsoft Defender for Office 365 scales with the growing needs of my company well.
Senior Client Director and Advisory Service Leader at Crossfuze
 

Stability Issues

Sentiment score
8.0
Cisco Secure Email is praised for reliability, consistent performance, easy maintenance, and high user satisfaction with stable uptime.
Sentiment score
7.7
Microsoft Defender for Office 365 provides 99.9% uptime with minor issues, ensuring reliable performance and seamless cloud integration.
Based on my experience, the stability of Cisco Secure Email is very strong.
Systems Engineer at a non-tech company with 51-200 employees
I would rate the stability of Microsoft Defender for Office 365 as 10 over 10 because it's highly available, it works, and it does the job it is meant to do.
Cloud Solutions Architect at a tech services company with 201-500 employees
I have not experienced any downtime, crashes, or performance issues because of Defender.
Technology Associate at a financial services firm with 51-200 employees
The solution is stable, as we have been using it for the past two years.
Solution Consultant at BIM Group of Companies
 

Room For Improvement

Cisco Secure Email's high cost, complexity, poor interface, and limited integration impact usability, requiring AI and service enhancements.
Users call for enhanced virus detection, cross-platform support, and pricing transparency in Microsoft Defender for Office 365.
The solution should better analyze the actual content rather than only focusing on the email header or origin.
Chief Information Security Officer at Abcl
It would be beneficial to have the functionality of the Email Threat Defense integrated into the Email Security Gateway so customers don't have to buy two products for full email protection.
Systems Engineer at a non-tech company with 51-200 employees
The main area for improvement is simplifying the implementation and rollout process.
Infrastructure and Security Lead at Vedanta
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
Solution Consultant at BIM Group of Companies
There is a different console for different things; I just want one consolidated console.
Senior Director, Security Architecture & Engineering at a leisure / travel company with 10,001+ employees
 

Setup Cost

Cisco Secure Email is priced higher, but users find its extensive features and security benefits justify the cost.
Microsoft Defender for Office 365 pricing is seen as flexible but potentially expensive, offering value in comprehensive security features.
Its cost is bundled with other Cisco products.
Chief Information Security Officer at Abcl
The licensing is a mess and needs sorting out.
Cloud Partner & Solutions Architect at a tech vendor with 1,001-5,000 employees
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
Systems Engineer at a non-tech company with 51-200 employees
We've likely saved 30% of costs.
Designation Chief Consultant at Avtow
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Infrastructure and Security Lead at Vedanta
Microsoft is quite affordable with a lot of features available for any size organization.
Solution Consultant at BIM Group of Companies
 

Valuable Features

Cisco Secure Email provides comprehensive threat management with advanced filtering, intuitive management, and seamless integration, enhancing email security effectively.
Microsoft Defender for Office 365 enhances email security with anti-phishing, anti-malware, threat intelligence, and seamless integration for efficient management.
It also possesses multiple modules for spam detection, malware detection, and threat intelligence, which are valuable in categorizing emails and determining actions.
Chief Information Security Officer at Abcl
It is highly effective in catching phishing and spam emails.
Systems Engineer at a non-tech company with 51-200 employees
It covers everything through email, like antivirus, IDS, and IPS.
Cloud Partner & Solutions Architect at a tech vendor with 1,001-5,000 employees
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
Technology support manager at Alfred State College
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
Solution Consultant at BIM Group of Companies
The value of the DLP feature is significant to us because we have internal data, sometimes sensitive, and the users may not always be aware of security and privacy, which might lead them to send out information mistakenly to external parties.
Chief Architect at a tech vendor with 1,001-5,000 employees
 

Categories and Ranking

Cisco Secure Email
Ranking in Email Security
5th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
62
Ranking in other categories
Cisco Security Portfolio (6th)
Microsoft Defender for Offi...
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
60
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
 

Mindshare comparison

As of January 2026, in the Email Security category, the mindshare of Cisco Secure Email is 5.2%, down from 7.2% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 9.6%, down from 13.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3659.6%
Cisco Secure Email5.2%
Other85.2%
Email Security
 

Featured Reviews

BD
Chief Information Security Officer at Abcl
Threat intelligence with fast attack detection enables comprehensive email protection
In some cases, detection is missed, leading to false positives where genuine emails are flagged as spam. This could result in users not opening genuine emails. We have highlighted this to Cisco because sometimes phishing or marketing campaigns, which are genuine, are incorrectly flagged as spam. The solution should better analyze the actual content rather than only focusing on the email header or origin.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
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879,711 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
18%
Manufacturing Company
9%
Financial Services Firm
8%
Comms Service Provider
5%
Computer Software Company
15%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business22
Midsize Enterprise18
Large Enterprise25
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise10
Large Enterprise31
 

Questions from the Community

What do you like most about Cisco Secure Email?
Cisco Secure Email is a budget-friendly solution.
What is your experience regarding pricing and costs for Cisco Secure Email?
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
What needs improvement with Cisco Secure Email?
The user interface of the Email Security Gateway ( /products/security-gateway-reviews ) should be improved. It would be beneficial to have the functionality of the Email Threat Defense integrated i...
What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
 

Also Known As

Cisco Email Security, IronPort, Cisco Email Security, ESA, Email Security Appliances
MS Defender for Office 365
 

Overview

 

Sample Customers

SUNY Old Westbury, CoxHealth, City of Fullerton, Indra
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email vs. Microsoft Defender for Office 365 and other solutions. Updated: December 2025.
879,711 professionals have used our research since 2012.