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Cisco Secure Email vs Microsoft Defender for Office 365 comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Feb 8, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cloudflare One
Sponsored
Ranking in Email Security
20th
Average Rating
8.6
Reviews Sentiment
6.5
Number of Reviews
23
Ranking in other categories
Secure Web Gateways (SWG) (12th), Data Loss Prevention (DLP) (21st), Cloud Access Security Brokers (CASB) (13th), Distributed Denial-of-Service (DDoS) Protection (8th), Software Defined WAN (SD-WAN) Solutions (12th), Access Management (11th), Bot Management (3rd), ZTNA as a Service (9th), ZTNA (4th), Secure Access Service Edge (SASE) (10th), Remote Browser Isolation (RBI) (3rd)
Cisco Secure Email
Ranking in Email Security
4th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
63
Ranking in other categories
Cisco Security Portfolio (6th)
Microsoft Defender for Offi...
Ranking in Email Security
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
 

Mindshare comparison

As of June 2026, in the Email Security category, the mindshare of Cloudflare One is 1.6%, up from 1.6% compared to the previous year. The mindshare of Cisco Secure Email is 4.5%, down from 6.4% compared to the previous year. The mindshare of Microsoft Defender for Office 365 is 6.3%, down from 12.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Defender for Office 3656.3%
Cisco Secure Email4.5%
Cloudflare One1.6%
Other87.6%
Email Security
 

Featured Reviews

CV
Network Architect at IP Dimension
Cloud security has improved remote access and has reduced costs for smaller client sites
I have used Cloudflare One's Identity-Aware Proxy, and it is quite straightforward from what I have seen so far. The app registration on the Azure side integrates fully into Cloudflare, and I am very satisfied with that part because it is easy to set up. The integration of Cloudflare One's Secure Web Gateway and Zero Trust Network Access works without any issues. That part is pretty automatic, and if you complete the rest of the setup, it comes together by itself with no issues from my side. What makes it nice is that we can actually start replacing on-site firewalls at this stage for the smaller clients because it does not matter if they go to a coffee shop or work from home; they are still secured by the same connection. The hops get shorter and you get better latency. We have done testing to see if it is better. One thing that we did notice with our proof of concept with our current client is that they have people connecting from the UK. When they used their previous VPN solution, uploading CAD drawings and other files to the server took a long time. They mentioned that it is much quicker on Cloudflare One's solution. I definitely believe that is part of the improved performance, and I am satisfied with that as well. What is nice about Cloudflare One is that it makes the setup easier and also easier to train technicians to maintain it. Compared to legacy systems, we do not need to get fancy firewalls in place that are costly. That is definitely also a cost-saver with Cloudflare One.
KS
Technical Associate Network Security at Valuepoint Systems
Email security has protected financial data and provides clear tracking for every branch message
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it was a database error or something, but we feel some slowness in configuring DLP and other content filters compared to other consoles. It may have been due to on-premises, but it was much noisy at some times while configuring DLP. When we tried to configure a DLP policy, the console became much slower. In that case, we cannot see what had happened in the mail which was blocked at that time. It may take nearly an hour to get back to normal while configuring policies. That is the major issue in the product.
Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Clover is the best product globally."
"The tool also offers good scalability, and the dashboard, along with real-time analytics, is very good."
"Cloudflare Access is a stable solution."
"The simplicity of the solution is its valuable features as almost no effort was needed to learn the configurations. It is also one of the cheapest firewalls available in this category."
"Enables me to work from two locations."
"Cloudflare is simple to use."
"Cloudflare is by far the most effective solution that I have come across."
"Cloudflare One has assisted in securing my remote workforce through a SASE solution with Cloudflare One and the Workers part, although I am not currently using the Workers component."
"The Cisco Secure Email Gateway, in my opinion, is a really good device."
"I can customize the configuration and policies."
"For what you get for the product, the support, and the overall stability, it is definitely a good return on investment."
"IronPort allows visibility into the problem and an easy way to pinpoint policy offenders."
"Cisco's Secure Email integrates with Cisco Firewalls, utilizing the AMP as their anti-malware engine, which allows for information sharing between devices."
"The most valuable features of the Cisco ESA have to do with the intelligence they provide us, as they respond quickly to any phishing attacks and threats on the system."
"Email service is one of the services that we offer at Galaxy, and Cisco ESA has improved our business so much that our customers want to maintain their business with us for email security, with over 500 domains on our email platform and improved profitability in everything."
"There is a huge return compared to if we didn't have a gateway appliance, as far as blocking malicious emails."
"The ability to respond to threats if very important."
"It also gives the vulnerability status according to the versions you have selected. Let's say you have Google Chrome. It mentions the versions it has, and it updates. Within two hours of an update, it is reflected in the dashboard. That's really nice to have."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"The technical support is good and quick to resolve issues."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"Microsoft Defender for Office 365 is a cloud-based email filtering service that helps protect our organization against unknown malware and viruses by providing robust zero-day protection and includes features to safeguard our organization from harmful links in real-time."
"Microsoft Defender for Office 365's most valuable features are safe attachments and safe links."
 

Cons

"The onboarding process can be improved a little bit."
"Our customers no longer use Cloudflare because its service is subpar."
"Cloudflare DDoS has poor technical support."
"Lacks a VPN feature to provide a secure connection to the data center."
"Our customers no longer use Cloudflare because its service is subpar."
"The initial onboarding was causing us some confusion."
"The initial onboarding was causing us some confusion."
"Feedback could be enhanced. While I work efficiently with Clover as a partner in Mexico City, sometimes the information and requests are easier to manage with more concrete solutions."
"They can do it better with web links, with the URLs."
"Cisco Secure Email can be improved from the administrator's point of view. Usually, you have to work with different areas, and they can try to make it easy for the administrator to use different functions."
"The user interface needs massive improvement. While the device works fine and it's not complicated to write policies, renaming menu items and showing policy flow in conjunction with the application could help."
"We have Microsoft and we have the E5 licenses, they have more EDR responses on certain emails. That's something that Cisco ESA on the cloud doesn't have. They don't do anything about MITRE attacks. They only detect if there is a malicious email or a threat and they remove it."
"The tool's pricing can be improved."
"The pricing needs to be reconsidered or enhanced."
"I would rate the stability a six out of ten. We had multiple issues with the stability."
"We use the CLI for management, but it's not very good. It's based on Java and it's very difficult to use."
"To improve Microsoft Defender for Office 365, it would be nice to have more accessibility for users to see on their end what they are doing that could cause a threat."
"In some situations, it has not been able to pick impersonated emails having no attachments. Technical support definitely has a scope for improvement."
"Specifically, within Microsoft Defender for Office 365, I want it to improve the DLP capabilities."
"The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster."
"We are always looking for others tools to increase automation on tasks. There can be better integration with other solutions, such as PowerPoint and email."
"The changes to customer service, specifically the new model for support agreements, are not favorable."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"I'd like some additional features any product can give me to protect our environment in a better way."
 

Pricing and Cost Advice

"The pricing of the solution is cheap. The licensing cost is also very low. I rate the cost and pricing a three out of ten."
"My company has to make yearly payments towards the licensing costs attached to the solution. There are no hidden charges apart from the licensing costs of the solution."
"The solution's pricing lacks transparency."
"The pricing is somewhere in the middle. I would rate the pricing a seven out of ten."
"The prices are slightly expensive."
"The price tag is no longer $200,000, but rather $300,000 to $400,000. It's twice."
"Cloudflare Zero Trust Platform's pricing is good."
"The solution is not that expensive."
"Licensing costs depend on how many users there are. It could range between $5 and $7 per month, per user."
"The product's price falls on the higher side when compared to the other products on the market."
"Cisco Secure Email and the support are priced well. It's not cheap, but there are other solutions that offer less and cost so much. For example, Microsoft is more expensive than Cisco."
"We do annual licensing for Cisco Secure Email Gatewayand SMA together, and possibly SmartNet support. Packaged together, the cost is just under $38,000."
"It is a reasonably priced solution."
"I rate the product price as six on a scale of one to ten, where one means it is a very expensive tool."
"It is expensive. I would rate it 2 out of 10, where 1 is the most expensive and 10 is the cheapest."
"The solution is expensive."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"The product is very expensive."
"The product is expensive."
"It's a user-base subscription."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
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Top Industries

By visitors reading reviews
Construction Company
19%
Comms Service Provider
11%
Financial Services Firm
9%
Manufacturing Company
6%
Financial Services Firm
11%
Computer Software Company
9%
Manufacturing Company
9%
Comms Service Provider
5%
Computer Software Company
12%
Financial Services Firm
9%
Manufacturing Company
8%
Comms Service Provider
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise1
Large Enterprise12
By reviewers
Company SizeCount
Small Business22
Midsize Enterprise18
Large Enterprise26
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise12
Large Enterprise32
 

Questions from the Community

What needs improvement with Cloudflare Access?
Cloudflare Access has strong integration with Microsoft, among other platforms. However, when it comes to Kaspersky, ...
What is your primary use case for Cloudflare Access?
Cloudflare Access provides secure access to internal applications for employees, external members of the organization...
What advice do you have for others considering Cloudflare Access?
Cloudflare Access is one of the best integrations available. While about two hundred vendors offer similar services, ...
What is your experience regarding pricing and costs for Cisco Secure Email?
The pricing structure is good as it is user-based or email client-based, which is positive for clients.
What needs improvement with Cisco Secure Email?
The areas of Cisco Secure Email that could be improved or enhanced are the slowness in the console. I don't think it ...
What is your primary use case for Cisco Secure Email?
We are using Cisco Secure Email to monitor the outgoing and incoming mail traffic in our financial institute. We have...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking ...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
 

Also Known As

Cloudflare Area 1 Email Security, Cloudflare Bot Management, Cloudflare Gateway, Cloudflare Zero Trust Platform, Cloudflare DDoS, Cloudflare SASE & SSE Platform
Cisco Email Security, IronPort, Cisco Email Security, ESA, Email Security Appliances
MS Defender for Office 365
 

Overview

 

Sample Customers

23andMe
SUNY Old Westbury, CoxHealth, City of Fullerton, Indra
Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Find out what your peers are saying about Cisco Secure Email vs. Microsoft Defender for Office 365 and other solutions. Updated: April 2026.
896,563 professionals have used our research since 2012.