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Cisco Secure Endpoint vs Microsoft Defender XDR comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Sep 9, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Cisco Secure Endpoint enhances productivity and reduces costs by streamlining threat detection, integrating tools, and minimizing manual intervention.
Sentiment score
7.3
Microsoft Defender XDR delivers substantial ROI by streamlining operations, reducing costs, and enhancing security with consolidated functionalities.
We can quarantine and isolate a device within minutes.
Microsoft Defender XDR has saved me at least 50% of my time.
Ever since we turned on the M5 feature set back in June, we have seen a reduced number of potentially malicious clicks and faster alerting when incidents occur.
 

Customer Service

Sentiment score
6.1
Cisco Secure Endpoint support is praised for responsiveness and expertise, providing quick issue resolution and valuable user guidance.
Sentiment score
6.2
Microsoft Defender XDR support is responsive but varies; premium users receive faster resolutions than smaller organizations or basic plans.
Cisco has good technical support, especially considering these are newer solutions compared to traditional routing and switching products.
You get stuck in low-level support for way longer than you should, instead of them escalating the issue up the chain.
It's critical to escalate SEV B issues immediately to a domestic engineer.
Once issues are escalated to the second or third layer, the support is much better.
 

Scalability Issues

Sentiment score
8.4
Cisco Secure Endpoint is scalable, integrates with SecureX for efficient management, and supports diverse industries without extra resources.
Sentiment score
8.0
Microsoft Defender XDR offers scalable adaptability for large enterprises, accommodating diverse needs by leveraging flexible cloud infrastructure and licensing.
Cisco Secure Endpoint is definitely scalable.
Microsoft Defender XDR shows tremendous scalability, much more so than on-premises solutions.
Microsoft Defender XDR scales pretty well.
It is suitable for enterprise-level deployment but has room for improvement.
 

Stability Issues

Sentiment score
6.5
Cisco Secure Endpoint is highly stable, reliable, and trusted for performance, earning high ratings from users in various enterprises.
Sentiment score
7.9
Microsoft Defender XDR is highly reliable but has occasional performance issues on macOS/Linux and alert misclassifications.
We have not encountered any problems.
The service has remained consistently online, with any issues isolated to specific components, suggesting a well-designed and modular architecture.
The services within our ecosystem have been reliable, meeting their SLAs.
It provides high-fidelity signals.
 

Room For Improvement

Cisco Secure Endpoint requires better integration, reporting, and UI enhancements, alongside improved pricing, AI capabilities, and IoT support.
Microsoft Defender XDR requires improved UI, integration, clarity, support, AI, and threat detection for better user experience.
The forensic capabilities need enhancement, especially for deep forensic data collection.
The licensing process needs improvement and clarification.
Improvements are needed in automated response capabilities.
Some inconsistencies exist between blades, which could be improved for a more seamless user and UI experience.
 

Setup Cost

Cisco Secure Endpoint offers competitive and flexible pricing with value-rich features, despite some complexity in licensing.
Microsoft Defender XDR pricing varies; it's cost-effective with Microsoft 365, but potentially expensive standalone for smaller businesses.
Cisco is aggressive in pricing, making it competitive and sometimes even cheaper than other good products like CrowdStrike, Microsoft Defender, or SentinelOne.
There are certainly savings when using Microsoft Defender XDR, which can range from 30%, 40%, and even up to 50%.
I would rate the pricing as eight out of ten, indicating it is a reasonable cost for the product.
Microsoft purposefully obfuscates this through marketing ploys to hide costs.
 

Valuable Features

Cisco Secure Endpoint provides advanced security features, cross-platform support, and ease of use with strong threat intelligence and support.
Microsoft Defender XDR offers seamless integration, advanced threat management, and automation, enhancing security efficiency while reducing costs and tool complexity.
Cisco Secure Endpoint is very good in machine learning, which allows it to secure offline contents even if not connected to the internet.
With Microsoft threat intelligence information, it detects various types of threats, including insider attacks, malicious content, and data exfiltration.
This allows us to secure our systems in advance and proactively improve security, rather than waiting for incidents to occur.
Once we have it on the security dashboard, we can see a real-time storyline.
 

Categories and Ranking

Cisco Secure Endpoint
Ranking in Endpoint Detection and Response (EDR)
15th
Average Rating
8.6
Reviews Sentiment
7.2
Number of Reviews
49
Ranking in other categories
Endpoint Protection Platform (EPP) (12th), Cisco Security Portfolio (6th)
Microsoft Defender XDR
Ranking in Endpoint Detection and Response (EDR)
5th
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
101
Ranking in other categories
Extended Detection and Response (XDR) (3rd), Microsoft Security Suite (3rd)
 

Mindshare comparison

As of June 2025, in the Endpoint Detection and Response (EDR) category, the mindshare of Cisco Secure Endpoint is 1.6%, down from 2.0% compared to the previous year. The mindshare of Microsoft Defender XDR is 3.0%, down from 3.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Detection and Response (EDR)
 

Featured Reviews

Ahmed-Dawood - PeerSpot reviewer
A tool that offers good performance and technical support along with great protection to endpoint devices
The vendor from Cisco takes care of the maintenance. We need three people to take care of the tool in case of crashes. From the dashboard, we come to know about everything related to the endpoint. You can take action unless it is not the physical hardware to which something wrong has happened, especially if something wrong happens to the operating system. I would definitely recommend the solution to those planning to use it. To provide endpoint protection, I feel the product should be speedy enough to detect malicious programs and trojans. There are a lot of tools that are not acting as signature-based but as behavior-based antivirus. Cisco Secure Endpoint is required, especially if the customers don't have a sandbox. Overall, I rate the product an eight out of ten.
Gabor Nyerd - PeerSpot reviewer
Includes four services and four products, which can help organizations a lot
We found that sometimes integrations work, but testing them can take some time. Sometimes, configurations take much longer than expected. We have a configuration in place that needs to be synchronized with another server. However, the servers are four hours apart, so this can cause delays. In general, I believe that the time it takes to configure and test a service should be shorter. Sometimes, it can take a couple of hours to test a single configuration setting. Other times, it is only ten or fifteen minutes, which is normal. However, sometimes, even immediate actions can be triggered by configuration changes, and some settings can take up to eight hours to complete. I believe that this time can be improved. Microsoft is making a lot of improvements to its services in a short period of time. This is a good thing, as it means that the services are constantly being updated and improved. However, it can be challenging for customers to keep up with the changes. For example, a customer may read about an update, understand it, and share it with their colleagues and boss. However, it may take days or weeks to test the update and get the necessary approvals. This can be especially challenging for large customers with many users or machines. In some cases, Microsoft may change a service before the customer has had a chance to implement the previous update. This can be frustrating for customers, as it means that they have to constantly learn new things and adjust their workflows. On the one hand, it is important for Microsoft to keep updating and improving its services. This helps to ensure that the services are meeting the customers' needs and that they are staying ahead of the competition. Microsoft should also be mindful of the challenges that these changes can create for customers. One way to address this challenge is to provide customers with more time to implement changes. Microsoft could also provide more information about upcoming changes so that customers can plan ahead. Ultimately, Microsoft needs to strike a balance between keeping its services up-to-date and providing customers with a smooth transition to new features.
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Top Industries

By visitors reading reviews
Computer Software Company
22%
Manufacturing Company
8%
Government
8%
Financial Services Firm
7%
Computer Software Company
17%
Financial Services Firm
9%
Manufacturing Company
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Cisco Secure Endpoint?
The product's initial setup phase was very simple.
What is your experience regarding pricing and costs for Cisco Secure Endpoint?
Cisco is aggressive in pricing, making it competitive and sometimes even cheaper than other good products like CrowdStrike, Microsoft Defender, or SentinelOne.
What needs improvement with Cisco Secure Endpoint?
Cisco Secure Endpoint lacks features like DLP which other vendors offer. XDR is new, so integration capabilities with third-party tools need improvement. The forensic capabilities need enhancement,...
What do you like most about Microsoft 365 Defender?
Microsoft Defender XDR provides strong identity protection with comprehensive insights into risky user behavior and potential indicators of compromise.
What is your experience regarding pricing and costs for Microsoft 365 Defender?
The pricing for Microsoft Sentinel operates on a pay-as-you-go model based on data ingestion. I recall that Defender XDR pricing is based on the number of endpoints.
What needs improvement with Microsoft 365 Defender?
For Microsoft Defender XDR ( /categories/extended-detection-and-response-xdr ), there is currently no ability to reset passwords for on-premises accounts, which is a key challenge. Incident managem...
 

Also Known As

Cisco AMP for Endpoints
Microsoft 365 Defender, Microsoft Threat Protection, MS 365 Defender
 

Overview

 

Sample Customers

Heritage Bank, Mobile County Schools, NHL University, Thunder Bay Regional, Yokogawa Electric, Sam Houston State University, First Financial Bank
Accenture, Deloitte, ExxonMobil, General Electric, IBM, Johnson & Johnson and many others.
Find out what your peers are saying about Cisco Secure Endpoint vs. Microsoft Defender XDR and other solutions. Updated: June 2025.
859,533 professionals have used our research since 2012.