We generally use it for reporting. It's to have transparency, to get to the incremental values. We do have value streams built up on Align and we get the metrics, how the program works, or the dependencies, not just between the teams, between the programs, or between the portfolios.
What you have in Jira are the scalability and the agile approach. It's all about getting to all the stakeholders or the enterprise users so that they can see what is happening from the bottom to the top or from top to bottom and how it's happening.
When it's all other agile tools, you could just view what each team is doing, and how the work is delivered within the team. However, it is going above and beyond the teams. When you are doing a scaled agile, when it all involves the whole enterprise, you use the Jira Align. It's a combination when you try to do the scaled agile combining the teams, combining the programs, and combining the portfolios, that is when the Jira Align is of most use.
We use Jira Align on top of Safe 4.0 right now. They're not supporting Safe 5.0 yet, however, they are using it as VR; I used it on top of the framework as Safe 4.0.