Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

Why PeerSpot?

Microsoft and Trellix are both solutions in the Advanced Threat Protection (ATP) category. Microsoft is ranked #3 with an average rating of 8.5, while Trellix is ranked #22 with an average rating of 9.0. Microsoft holds a 6.0% mindshare in ATP, compared to Trellix’s 2.1% mindshare. Additionally, 96% of Microsoft users are willing to recommend the solution, compared to 76% of Trellix users who would recommend it.

Microsoft Defender for Offi...

Read 61 Microsoft Defender for Office 365 reviews

18,434 Views
4,609 Comparison Views

96% willing to recommend

Trellix Advanced Threat Def...

Read 9 Trellix Advanced Threat Defense reviews

1,935 Views
1,645 Comparison Views

76% willing to recommend

Microsoft Defender for Offi...

Trellix Advanced Threat Def...

Comparison Buyer's Guide

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Executive SummaryUpdated on Dec 1, 2024

Trellix Advanced Threat Defense and Microsoft Defender for Office 365 are competing security solutions in advanced threat protection. Microsoft Defender for Office 365 appears superior due to its extensive feature set.

Features: Trellix Advanced Threat Defense provides advanced malware detection, sandboxing capabilities, and targeted threat detection. Microsoft Defender for Office 365 offers robust email protection, phishing prevention, and seamless integration within the Office ecosystem, ensuring comprehensive real-time threat intelligence.

Room for Improvement: Trellix Advanced Threat Defense could enhance ease of deployment, streamline advanced configurations, and expand integration capabilities with other platforms. Microsoft Defender for Office 365 might improve customization options for security policies, reduce setup costs, and provide more detailed threat analytics for specific business models.

Ease of Deployment and Customer Service: Microsoft Defender for Office 365 is praised for its smooth integration with Microsoft products, supported by extensive documentation and dedicated customer service. Trellix Advanced Threat Defense offers personalized customer support but may face challenges due to its complex deployment configurations.

Pricing and ROI: Trellix Advanced Threat Defense offers a cost-effective solution with promising ROI via targeted threat capabilities, appealing to budget-conscious buyers. Microsoft Defender for Office 365, while potentially more expensive upfront, justifies the cost with comprehensive security and ROI through seamless Office integration.

To learn more, read our detailed Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense Report (Updated: September 2026).

Buyer's Guide

Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense

September 2026

Download the complete report

Helped 919,341 peers since 2012

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Microsoft Defender for Offi...

Ranking in Advanced Threat Protection (ATP)

3rd

Average Rating

8.4

Reviews Sentiment

6.8

Number of Reviews

Ranking in other categories

Email Archiving (2nd), Email Security (2nd), Microsoft Security Suite (9th), Secure Email Gateway (SEG) (2nd)

Trellix Advanced Threat Def...

Ranking in Advanced Threat Protection (ATP)

22nd

Average Rating

7.8

Reviews Sentiment

5.6

Number of Reviews

Ranking in other categories

No ranking in other categories

Mindshare comparison

As of October 2026, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 6.0%, down from 13.1% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.1%, up from 1.6% compared to the previous year. It is calculated based on PeerSpot user engagement data.

Advanced Threat Protection (ATP) Mindshare Distribution
Product	Mindshare (%)
Microsoft Defender for Office 365	6.0%
Trellix Advanced Threat Defense	2.1%
Other	91.9%

Advanced Threat Protection (ATP)

Featured Reviews

Emeka Ndulu

Cloud Solutions Architect at a tech services company with 201-500 employees

Improves threat visibility and response while reducing manual tasks and training users against phishing

I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.

Read full review

Philippe Panardie

RSSI at SDIS49

Ensuring long-term reliability while seeking internal email management enhancements

Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Read full review

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."

"Defender helps us prioritize threats across our organization."

"The feature I like the most about Microsoft Defender for Office 365 is that it typically runs in the background—you do not know it is there until you need to access it."

"It definitely is a must for email protection and O365 app DLP, and combined with Microsoft Defender for Endpoint, Microsoft Defender for Identity, and MCAS, it provides a holistic solution for threat protection, email protection, O365 apps protection, and DLP for both internal and external risks."

"Microsoft Defender for Office 365 is a stable solution."

"It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment."

"The most valuable feature is the integration; it's a single console, so we don't have to switch around between multiple products, and another valuable feature is the ease of operations and maintenance."

"Defender is a SaaS platform, so it offers more flexibility. Managing the permissions is easier. The solution's automated detection and response features are scalable."

More Microsoft Defender for Office 365 pros

"It was easy to set up initially."

"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."

"The product is expensive, but it is better than the rest of them in the industry."

"Provides good exfiltration, and is an all-in-one product."

"The most valuable features are the administration console and its detection and response module."

"I recommend this solution because of its ease of use."

"If a system admin can put in the patience to read and constantly update the ePO system in terms of rules, enforcing them at regular intervals, you can safely go to sleep every night."

"This solution is very easy to use and requires little to no training."

More Trellix Advanced Threat Defense pros

Cons

"The product must provide better malware detection."

"I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost."

"The pre-sales cost calculations could be more transparent."

"Microsoft Defender for Office 365 should improve the troubleshooting tools. It's unclear whether the device is blocked at the firewall level or at the device itself. The granularity needed for troubleshooting is currently lacking. From my perspective, Microsoft should address this issue to benefit many users who likely share the same sentiment."

"The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster."

"Configuration requires going to a lot of places rather than just accessing one tab."

"We noticed that from time to time, Microsoft's stability does have problems. Sometimes the service goes up and down. Sometimes they change without prior notice."

"Microsoft Defender for Office 365 is not up to the mark in comparison with Wiz or Palo Alto."

More Microsoft Defender for Office 365 cons

"This product does the job, but it is not flexible enough to do new environments yet."

"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."

"I would like to see future versions of the solution incorporate artificial intelligence technology."

"We'd like them to be better at dealing with script threats."

"Some of our customers have mentioned the lack of a tool that would allow for remote capabilities without being attached to the internet."

"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."

"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."

"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."

More Trellix Advanced Threat Defense cons

Pricing and Cost Advice

"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."

"The product is expensive."

"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."

"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."

"From the pricing point of view, like any other product in the market, there is scope for negotiation."

"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."

"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."

"It's a user-base subscription."

More Microsoft Defender for Office 365 pricing and cost advice

"Our licensing fees for this solution are approximately one million dollars per year."

"The product is expensive, but it is better than the rest of them in the industry."

See which vendors are best for you

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Top Industries

By visitors reading reviews

Computer Software Company

11%

Manufacturing Company

10%

Financial Services Firm

Comms Service Provider

Construction Company

15%

Outsourcing Company

15%

Financial Services Firm

13%

Manufacturing Company

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	24
Midsize Enterprise	11
Large Enterprise	32

By reviewers
Company Size	Count
Small Business	3
Midsize Enterprise	4
Large Enterprise	5

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?

My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...

See all answers

What needs improvement with Microsoft Defender for Office 365?

I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...

See all answers

What is your primary use case for Microsoft Defender for Office 365?

My main use cases for Microsoft Defender for Office 365 include email hygiene.

See all answers

What needs improvement with McAfee Advanced Threat Defense?

I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...

See all answers

What is your primary use case for McAfee Advanced Threat Defense?

We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...

See all answers

What advice do you have for others considering McAfee Advanced Threat Defense?

See all answers

Comparisons

Proofpoint Email Protection vs Microsoft Defender for Office 365

Compared 5% of the time

Check Point Email Security (formerly Harmony Email & Collaboration) vs Microsoft Defender for Office 365

Compared 3% of the time

Mimecast Advanced Email Security vs Microsoft Defender for Office 365

Compared 3% of the time

Cisco Secure Email vs Microsoft Defender for Office 365

Compared 3% of the time

Barracuda Email Protection vs Microsoft Defender for Office 365

Compared 3% of the time

More Microsoft Defender for Office 365 Competitors

NetWitness Platform vs Trellix Advanced Threat Defense

Compared 16% of the time

Fortinet FortiSandbox vs Trellix Advanced Threat Defense

Compared 8% of the time

Digital Guardian vs Trellix Advanced Threat Defense

Compared 6% of the time

Check Point Infinity vs Trellix Advanced Threat Defense

Compared 6% of the time

Microsoft Defender for Identity vs Trellix Advanced Threat Defense

Compared 5% of the time

More Trellix Advanced Threat Defense Competitors

Product Reports

Buyer's Guide

Microsoft Defender for Office 365

October 2026

Microsoft Defender for Office 365 report

Download Microsoft Defender for Office 365 product report

Buyer's Guide

Trellix Advanced Threat Defense

October 2026

Download Trellix Advanced Threat Defense product report

Also Known As

MS Defender for Office 365

McAfee Advanced Threat Defense

Overview

Microsoft Defender for Office 365 offers real-time email security, enhancing threat detection through integration within the Microsoft ecosystem. Its user-friendly interface and central management streamline operations, providing robust protection against phishing, ransomware, and malware.

Defender for Office 365 is focused on efficiently securing email communication by safeguarding against phishing, malware, and spam threats. With its strong integration with other Microsoft services, it is tailored to improve endpoint security and identity protection. Its centralized management tools simplify threat prioritization, while the automated threat response capabilities ensure swift actions against potential risks. Organizations leverage its capabilities to efficiently manage their cybersecurity efforts, particularly in remote work environments, while maintaining a secure system across Office 365 applications and Azure-hosted services.

What are the key features?

Real-time Email Protection: Continuously monitors and protects email communications.
Safe Attachments and Links: Scans attachments and links for potential threats.
Anti-Phishing Measures: Provides tools to detect and block phishing attempts.
Integration with Microsoft Services: Seamlessly connects with other Microsoft applications for enhanced security.
Automated Threat Responses: Activates immediate responses to detected threats.

What benefits should users expect from reviews?

Time Savings: Automates processes to reduce manual threat management efforts.
Improved Cybersecurity: Strengthens organizational defenses against various cyber threats.
Efficient Remote Work: Enhances protection for remote teams and virtual collaborations.
Comprehensive Coverage: Extends protection across Office 365 and Azure services.

Implementations of Defender for Office 365 vary across industries, optimizing email security for sectors such as finance, healthcare, and education. In finance, it aids in protecting sensitive financial data from phishing and fraud. Healthcare benefits from secure communications, ensuring patient data privacy. Educational institutions use it to maintain secure virtual learning environments against cyber threats.

Microsoft

Trellix Advanced Threat Defense offers efficient threat detection and automatic threat remediation, featuring seamless management and integration with operating systems and extensions.

Providing robust malware defense, Trellix Advanced Threat Defense is easy to set up and use. Its components work collaboratively, with standout features like behavioral analysis, retro-inspection, and ePolicy Orchestration. Despite its strengths, users suggest improvements in Active Directory integration, cloud readiness, artificial intelligence, and faster sandboxing. The API interface and scalability need enhancement, while better compatibility with platforms like Cisco could elevate its function. Effective for server and endpoint security, it effectively blocks threats like WannaCry and disperses attack data through the DXL client quickly.

What are the notable features of Trellix Advanced Threat Defense?

Management and Automatic Threat Remediation: Facilitates seamless management and handling of threats.
Effective Threat Detection and Response: Delivers efficient and reliable threat detection capabilities.
Behavioral Analysis and Retro-Inspection: Offers advanced analysis for comprehensive threat identification.
ePolicy Orchestration: Streamlines processes for enhanced threat management.
Scalability and Price: Provides a stable and scalable solution at a competitive price point.

What key benefits can be identified from reviews?

Ease of Use and Setup: Known for its straightforward implementation and user-friendly interface.
Integration Capabilities: Works well with different operating systems and technologies like Palo Alto firewalls.
Threat Protection Efficiency: Proven effectiveness in stopping threats such as WannaCry.
Rapid Attack Information Dissemination: Utilizes the DXL client for quick data sharing.

Trellix Advanced Threat Defense is widely used across numerous industries for server and desktop protection, ensuring endpoint security and halting attacks without failure. Its integration with diverse technologies enhances protection in varied environments, making it a valuable tool in enterprise security management.

Trellix

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.

The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust

Buyer's Guide

Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense

September 2026

Free Report: Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense

Find out what your peers are saying about Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense and other solutions. Updated: September 2026.

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