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Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
53
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
21st
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of October 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 7.7%, down from 12.1% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.0%, up from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3657.7%
Trellix Advanced Threat Defense2.0%
Other90.3%
Advanced Threat Protection (ATP)
 

Featured Reviews

Vikas Ingle - PeerSpot reviewer
Centralized tenant enables group control but setup process complicates implementation
Actually earlier, I used to have full controls with Trend Micro. Microsoft Defender for Office 365 is now part of a centralized tenant for my entire group. I don't have control on that, as another team is maintaining it. Since I don't have full visibility of the features, I cannot make significant comments.
PP
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Microsoft Defender for Office 365 is a stable solution."
"Safe attachments, safe links, policies, and the ability to protect from zero-day threats are the most valuable features."
"The good part is that you don't have to configure it, which is very convenient."
"The most valuable feature is the integration. It's a single console, so we don't have to switch around between multiple products. Another valuable feature is the ease of operations and maintenance."
"Some of the valuable features on the email side are anti-phishing, anti-malware, and Safe Links."
"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"The initial setup was easy."
"We use Microsoft Defender for its ability to integrate with existing business technologies, which is beneficial for protecting business areas."
"The most valuable features are the administration console and its detection and response module."
"It stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"I recommend this solution because of its ease of use."
"It is very scalable."
"Provides good exfiltration, and is an all-in-one product."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."
"It is stable and reliable."
 

Cons

"Microsoft should provide more documentation for users so they can self-educate. I would like to see more documentation for advanced security features."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"It would be better if it were more scalable. It depends on the architecture, but we would like to make it more scalable for both data centers."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"About eight months ago, we started to measure the quantity of phishing and spam that we have been receiving, and it has been increasing a lot. That means that protection for our email is not as good as we were expecting."
"Configuring the default strategies and policies in Microsoft Defender for Cloud Apps generates a lot of noise and false positives."
"I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"This solution needs to be made "cloud ready"."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"Lacks remote capabilities not dependent on the internet."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"We'd like them to be better at dealing with script threats."
 

Pricing and Cost Advice

"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"The product is very expensive."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"It's a user-base subscription."
"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Computer Software Company
15%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
Government
16%
Comms Service Provider
15%
Performing Arts
11%
Financial Services Firm
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise8
Large Enterprise27
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
I think that Microsoft Defender for Office 365 could be improved if it could use VirusTotal to compare the programs or anything that I download. VirusTotal helps to identify viruses, malware, troja...
What do you like most about McAfee Advanced Threat Defense?
I recommend this solution because of its ease of use.
What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
 

Also Known As

MS Defender for Office 365
McAfee Advanced Threat Defense
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Trellix Advanced Threat Defense and other solutions. Updated: September 2025.
872,019 professionals have used our research since 2012.