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Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco HyperFlex HX-Series [...
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
90
Ranking in other categories
No ranking in other categories
Nutanix Cloud Infrastructur...
Average Rating
8.6
Reviews Sentiment
7.4
Number of Reviews
197
Ranking in other categories
Software Defined Storage (SDS) (4th), HCI (3rd), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (4th)
 

Featured Reviews

Nuno Mendes - PeerSpot reviewer
High performance solution that makes it easy to efficiently manage VM resources
In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).
MahendraPanchotiya - PeerSpot reviewer
Offers a unified platform, reduces downtime, and simple updates
Nutanix offers a unified platform for managing databases, virtual machines, and applications. This simplifies management by consolidating everything into a single interface. While Nutanix may have a higher upfront cost compared to other hypervisors, it can significantly reduce the resources needed for infrastructure management. With our previous hypervisor, we needed nearly ten IT personnel. Nutanix has allowed us to streamline our team to just three members. We use a combination of database technologies, including SQL databases and web servers such as IIS, BHP, and NGINX. Nutanix features helped our organization reduce downtime. I don't recall the last time we had downtime related to Nutanix because it is such a stable product. Nutanix, a reliable product, helps us streamline our processes, which in turn improves company revenue. We began to see the benefits after two years, with a 40 percent reduction in operational costs. We migrated 200 servers from AWS to Nutanix. Nutanix may not consolidate applications, but it helps us run them more efficiently on its platform. Updating is simple with one click. I would rate the updating processes 10 out of 10. Adding compute and storage on demand is not difficult. However, we need to factor in the existing and new firmware and software requirements.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The most valuable feature of Cisco HyperFlex HX-Series is its performance."
"This is not the only product we use, so we have other solutions to compare it with. We can compare different products and different vendors and tell our customers which products have which advantages and disadvantages so that they can leverage these products in their own environment. This product helps us to understand the customer's needs and what issues they can run into."
"It saves space for data centers, which is good."
"Cisco HyperFlex is helping us to put everything in centrally so that we can manage in one place."
"It is helpful as a backup solution."
"The solution is stable."
"The speed, storage, and management are the most valuable features."
"It is a solution that best suits thre needs of our organization."
"This operating system offers stability. Setup is straightforward."
"It is a good solution and it is easy to work on their platform."
"The initial setup was quite straightforward."
"The replication method between Nutanix clusters is a valuable feature."
"The most valuable feature I have found to be the Acropolis Hypervisor (AHV)."
"Nutanix has several unique capabilities to ensure linear scalability."
"Nutanix Acropolis AOS makes it easy to use and manage projects and it has a good reputation."
"Nutanix Acropolis AOS has very good stability."
 

Cons

"The initial setup of the Cisco HyperFlex HX platform was medium-level difficult. It's a little bit different from traditional servers. It takes getting used to the learning curve."
"We are working with a lot of different technologies and trying to manage them with one tool. The API could be improved for better integration with other systems."
"The initial setup can be complex."
"We had a bit of complexity to think about how to migrate our legacy infrastructure into Cisco HyperFlex."
"Lacks some integration and documentation could be improved."
"The product needs work in the area of deduplication which currently is inefficient."
"It would have been nice if the product provided some cloud integrations."
"We'd like the product to offer better integration with other products."
"The one note of improvement I have for Nutanix is that the installation should be easier."
"It already has the capability to integrate with the major cloud providers but, in an upcoming release, if there is a possibility to have it integrate with other cloud providers like IBM, Alibaba, and other moderate-level cloud providers, that would be good."
"The licensing cost could be lower."
"Nutanix Acropolis AOS could improve by adding some NAS features, similar to the ones that are available in the NetApp solution."
"Nutanix has a complex infrastructure, we have customers that consider VMware instead. Additionally, the performance could be better."
"Setup can be a little difficult"
"One disadvantage of Nutanix Acropolis AOS is it doesn't support external storage. Connecting external SAN storage to Nutanix, it's not supported."
"Native File-Services are under heavy development and Container Services just came out."
 

Pricing and Cost Advice

"Our licensing is Hybrid. We have all of our applications for billing and outage management through this."
"It's roughly $30,000 per Hyperflex license, so that would be about $60,000 a year."
"There is no additional licensing cost other than the cost for each part."
"The price is a bit high. It could be better, but the product is worth the cost."
"There is a license required to use this solution."
"Pricing is better if you buy more Cisco products."
"Cisco HyperFlex HX-Series is a bit pricier compared to other brands in the market...There is a need to make additional payments towards the maintenance and support of the solution."
"It is highly priced compared to other vendors."
"The license is quite clear to me. It's much clearer than what we had with our previous virtualization environment. The licensing is not complex to understand."
"Setup cost is minor, pricing is quite a bit (we have a 7-node-cluster for about 450K EUR with 2 vGPU-nodes for Citrix) but that includes hardware, software, and support."
"The overall cost depends on the contract of each customer and the discounts they have, but the price for the three-tier architecture can be slightly lower."
"Our Nutanix license is for five years. There is a support arrangement there, but that aspect is more or less taken care of during the initial installation. With HCI architecture, whenever we do any kind of auto scaling or scaling of servers and resources, there is a significant amount of software licensing involved."
"We got the renewal done recently, and there was no cost involved."
"Nutanix Cloud Infrastructure's core licensing needs to have an upper limit since processors are coming out with incredible numbers of cores on them."
"This product is less expensive than some of the competing HCI solutions."
"The price of the solution is high."
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Comparison Review

it_user244362 - PeerSpot reviewer
Aug 30, 2015
Nutanix vs. VMware EVO:RAIL vs. FlexPod
Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…
 

Answers from the Community

NC
Aug 2, 2022
Aug 2, 2022
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrat...
See 2 answers
Oct 17, 2021
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.
Steffen Hornung - PeerSpot reviewer
Aug 2, 2022
With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.
 

Top Industries

By visitors reading reviews
Computer Software Company
25%
Financial Services Firm
9%
Government
8%
Manufacturing Company
7%
Educational Organization
38%
Computer Software Company
12%
Financial Services Firm
6%
Manufacturing Company
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...
How does VxRail compare with Cisco HyperFlex HX Series?
VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...
What is the biggest difference between Nutanix Acropolis and VMware vSphere?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
Which would you choose - Nutanix Acropolis AOS or VMware vSAN?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
What makes Nutanix Cloud Infrastructure (NCI) worth using?
NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...
 

Also Known As

No data available
Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis
 

Overview

 

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest
St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.
Find out what your peers are saying about Dell Technologies, VMware, Nutanix and others in HCI. Updated: April 2025.
850,671 professionals have used our research since 2012.