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Cisco HyperFlex HX-Series [EOL] vs Nutanix Cloud Infrastructure (NCI) comparison

Cisco and Nutanix are both solutions in the HCI category. Additionally, 89% of Cisco users are willing to recommend the solution, compared to 94% of Nutanix users who would recommend it.
Nutanix Cloud Infrastructur...
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94% willing to recommend
 

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Executive SummaryUpdated on Jul 27, 2025

Nutanix Cloud Infrastructure and Cisco HyperFlex HX-Series compete in the hyper-converged infrastructure space. Nutanix appears to have the upper hand with its extensive feature set and cost-effectiveness, while Cisco offers strong integration within its ecosystem.

Features: Nutanix Cloud Infrastructure features data protection, one-click upgrades, and a comprehensive management interface that simplifies scalability. Cisco HyperFlex HX-Series excels in integration, flexibility, and scalability, forming a strong component within the Cisco ecosystem.

Room for Improvement: Nutanix could improve its pricing models and compatibility with older systems, and refine network features. Cisco HyperFlex HX should enhance its documentation, integration capabilities, and reduce reliance on specific hardware configurations.

Ease of Deployment and Customer Service: Nutanix is praised for easy deployment in both on-premises and hybrid environments, with top-tier technical support. Cisco HyperFlex provides reliable support, though the setup process is complex for cloud integrations, and has a steep learning curve for new users despite strong integration with Cisco products.

Pricing and ROI: Nutanix is cost-effective, typically seen as cheaper than Cisco and offers high ROI through reduced operational costs. Cisco HyperFlex is more expensive, potentially lacking a pricing advantage unless bundled with other Cisco products, which can affect ROI negatively, especially in smaller setups.

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September 2025
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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco HyperFlex HX-Series [...
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
90
Ranking in other categories
No ranking in other categories
Nutanix Cloud Infrastructur...
Average Rating
8.6
Reviews Sentiment
7.3
Number of Reviews
199
Ranking in other categories
Software Defined Storage (SDS) (5th), HCI (4th), Software Defined Data Center (SDDC) (1st), Hybrid Cloud Computing Platforms (4th)
 

Featured Reviews

Nuno Mendes - PeerSpot reviewer
High performance solution that makes it easy to efficiently manage VM resources
In our case as a credit recovery company working with the state, our infrastructure is fixed and stable as we don't have the same need for growth as other types of companies. That said, one of the biggest problems with HyperFlex HX is that if you want to adjust your solution in terms of processing power, memory, or disk capacity, you have to buy completely new hosts. From a financial perspective, it can be very expensive to do so, and from a legal perspective, there are all kinds of compliance issues we would have to sort out before buying any new solution or application. Since we as a company will only be operating for perhaps the next ten years, when our HyperFlex solution comes to its end-of-life in 2024 our next step will likely not be with HyperFlex or any other solution from Cisco. Instead, from a financial point of view, we will likely turn toward a cloud solution because, that way, we won't have to spend so much money on physical infrastructure. We are, after all, only a small company and HyperFlex can be very expensive for other companies of our size, whether in Portugal or elsewhere like the United States. One other area for improvement is in regard to HyperFlex's integration with VMware. HyperFlex integrates with a specific version of VMware in such a way that HyperFlex doesn't always resolve security issues with VMware at the same pace as what you see in native implementations of VMware. This has happened in one or two situations in the past. On the other hand, the integration is otherwise adequate, especially in terms of availability and virtualization features (such as being able to split up each of our four hosts within VMware).
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MahendraPanchotiya - PeerSpot reviewer
Offers a unified platform, reduces downtime, and simple updates
Nutanix offers a unified platform for managing databases, virtual machines, and applications. This simplifies management by consolidating everything into a single interface. While Nutanix may have a higher upfront cost compared to other hypervisors, it can significantly reduce the resources needed for infrastructure management. With our previous hypervisor, we needed nearly ten IT personnel. Nutanix has allowed us to streamline our team to just three members. We use a combination of database technologies, including SQL databases and web servers such as IIS, BHP, and NGINX. Nutanix features helped our organization reduce downtime. I don't recall the last time we had downtime related to Nutanix because it is such a stable product. Nutanix, a reliable product, helps us streamline our processes, which in turn improves company revenue. We began to see the benefits after two years, with a 40 percent reduction in operational costs. We migrated 200 servers from AWS to Nutanix. Nutanix may not consolidate applications, but it helps us run them more efficiently on its platform. Updating is simple with one click. I would rate the updating processes 10 out of 10. Adding compute and storage on demand is not difficult. However, we need to factor in the existing and new firmware and software requirements.
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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The management feature is the solution's most valuable aspect."
"Easily facilitates remote work opportunities with storage and compute resources."
"The initial setup is easy."
"The integration between the storage and the server applications is the most valuable feature of this solution. It cuts down on the necessity to buy a secondary storage system.. It saves money in the long-run."
"There are some slight cost advantages when you need fewer resources to manage it."
"Most of our users are Cisco customers, so it fits in within the suites we use. Primarily for me, as a solution architect, it's the technology and architecture that is the most valuable. I know from my technical colleagues that it's easy to use and for the customer, the up-time is the most valuable asset. It's running, has low failure, and so on which is why we use it."
"It's easy to get the tool started."
"It allows us to authorize our residents to come in using their own personal devices to access any of our clinical applications and ensure that the PHI is secure and protected."
More Cisco HyperFlex HX-Series [EOL] pros
"The interface is very good. Before we used this solution, we had separate storage and switches, but with the hyper convert, it's all in one."
"The replication method between Nutanix clusters is a valuable feature."
"In the world of IT operations, there is a lot of noise. Traditionally, systems would generate a great deal of alerts, events, and notifications, often leading to the operator either a) not seeing critical alerts since they are lost in the noise or b) disregarding the alerts/events."
"I definitely find the reduced power consumption very valuable. Another aspect I really like, when one compares Citrix to VMware, is the interface where you talk directly to your VM from the present software."
"The snapshots, cloning, and replication are all effective in helping to reduce downtime. It can replicate cluster data for disaster recovery and it provides high availability in case a node or a disk fails."
"The feature that I have found most valuable is its software Move, which we use to migrate virtual info from another platform to the Nutanix platform."
"It's easy to use and has a very smooth onboarding process."
"The fact that there is only one interface to deploy a complete solution for maximum storage is fantastic."
More Nutanix Cloud Infrastructure (NCI) pros
 

Cons

"I would like for them to develop integration with other technologies, like SD Access. It's still lacking an enhancement management player."
"We would like HyperFlex to connect the storage directly into Fabric Interconnect along with the features of the solution. We have enough ports in HyperFlex. We don't want to buy another set of switches to connect to Fabric Interconnect, complicating the solution."
"Lacks some integration and documentation could be improved."
"There are sometimes issues with memory failure."
"I would like a lighter product; something which can be carried by a mere human. The typical size still looks like a stack of data center-sized servers, which is typically fine, but not so good if you want to carry it around."
"If we could have just a single pane of glass, where everything can be managed through that one app, rather than have multiple apps, it would be great."
"Cisco is a bit more challenging in terms of deployment. The admin must be knowledgeable in order to complete the task. Without that knowledge, it will be difficult to complete."
"We had a bit of complexity to think about how to migrate our legacy infrastructure into Cisco HyperFlex."
More Cisco HyperFlex HX-Series [EOL] cons
"There are other services that Nutanix has that could be improved, but I'm not very familiar with the other services of Nutanix, such as Era and Flow. However, they seem a bit hard for us to implement and integrate with the Nutanix Acropolis AOS and other Nutanix tools. We would not dare to implement those other Nutanix solutions into Nutanix Acropolis AOS right now. The implementation of that tool could be the problem, I am a bit hesitant to implement the other tools into Nutanix Acropolis AOS."
"Some clients find the solution's cost to be too high."
"It would be ideal if it was more secure."
"In terms of automation, I know there are ways to do it, but it's not very user-friendly. I've been working for the last three years with Nutanix and I've managed to automate certain things, but it's a somewhat more complex job than it should be. I would like to see more documentation or knowledge base articles."
"The one note of improvement I have for Nutanix is that the installation should be easier."
"It would be great if it could emulate some of the features that their competitor VMware has, for example port mirroring or Netflow output at hypervisor level."
"There could be better support for high power ESX and other cross platform applications."
"The latency needs improvement"
More Nutanix Cloud Infrastructure (NCI) cons
 

Pricing and Cost Advice

"It is relatively expensive, but it can easily return value by freeing up other resources."
"Comparable solutions with switches, storage, and services are cheaper than HyperFlex. It should be cheaper."
"It's roughly $30,000 per Hyperflex license, so that would be about $60,000 a year."
"Cisco HyperFlex HX-Series is a bit pricier compared to other brands in the market...There is a need to make additional payments towards the maintenance and support of the solution."
"There is a license required to use this solution."
"We have a yearly license."
"Its price is high. Cisco needs to work on the pricing model for this product. Nutanix or VMware are cheaper products, and they provide almost the same functionality. Its price is a big road blocker when we are working with an end customer, and Nutanix and VMware are in competition. If they can reduce its price, it is actually a better choice for customers."
"Our licensing costs are large, but it is combined between all of the Cisco products that we have."
More Cisco HyperFlex HX-Series [EOL] pricing and cost advice
"They should lower the price. If they did they would fall into a more competitive market because the price does scare a lot of potential customers away when they get the quote."
"Nutanix Acropolis AOS price includes no additional costs for features."
"Nutanix price is high because it bundles all the components into single deals rather than allowing you to select the features that you want/will use."
"It's a cost-effective solution"
"The pricing is fair for the package."
"AHV is free! This is a great feature that should be taken advantage of."
"The license is quite clear to me. It's much clearer than what we had with our previous virtualization environment. The licensing is not complex to understand."
"If a customer has been using VMware, the difference in pricing is lower. However, if they are looking to use the VMware, the price can be much higher depending on the license."
More Nutanix Cloud Infrastructure (NCI) pricing and cost advice
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Comparison Review

it_user244362 - PeerSpot reviewer
Aug 30, 2015
Nutanix vs. VMware EVO:RAIL vs. FlexPod
Originally posted at www.storagegaga.com/dont-get-too-drunk-on-hyper-converged/ I hate the fact that I am bursting the big bubble brewing about Hyper Convergence (HC). I urge all to look past the hot air and hype frenzy that are going on, because in the end, the HC platforms have to be aligned…
Read full review
 

Answers from the Community

NC
Aug 2, 2022
Aug 2, 2022
How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrat...
See 2 answers
LF
Oct 17, 2021
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper-converged infrastructure at scale. We looked into it but then ultimately chose Nutanix Acropolis. We liked Hyperflex’s virtualization feature and the unified network fabric it provides. The Integrated Managed Controller was a nice feature to have. It is expandable, stable, and has good redundancy. If you require more processor cores per box, Cisco HyperFlex is a good solution for you. Support will depend on the type of contract you have, with some requests taken care of immediately and others taking longer according to the engineer’s expertise. While Hyperflex is designed for any company size, I wouldn’t recommend them for small businesses. It also requires a solid knowledge of Cisco products, as the UI can be difficult to manage. Upgrading to a newer version can also be cumbersome and could use some improvement. We chose Nutanix because it is easier to use and is more cost-effective. Nutanix allows us to deploy, run and scale applications both on-premises and in the cloud. It has excellent support. You can log the query straight to a technical expert, which is good if you have staff not familiar with AOS. It is easy to scale by adding new nodes, and the company is constantly adding new features. Nutanix is not for everyone, though. The Nutanix Cloud System can be complex to maneuver when at the command line or when troubleshooting. Conclusions Nutanix is better for medium-sized companies and when you need a cost-effective solution. Cisco Hyperflex is a complete solution but is better suited for large enterprises. It works better if you are already a Cisco user.
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Steffen Hornung - PeerSpot reviewer
Aug 2, 2022
With Nutanix you have the freedom of choice. You can deploy it with several server hardware vendors or completely in the cloud. I don’t know Hyperflex at heart, though. Also, support at Nutanix is outstanding.
Read full answer
 

Top Industries

By visitors reading reviews
Computer Software Company
18%
Financial Services Firm
9%
Government
8%
Manufacturing Company
7%
Computer Software Company
17%
Financial Services Firm
9%
Manufacturing Company
8%
Government
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise17
Large Enterprise57
By reviewers
Company SizeCount
Small Business91
Midsize Enterprise76
Large Enterprise82
 

Questions from the Community

How do I choose between Cisco Hyperflex HX Series and Nutanix Acropolis AOS?
Cisco HyperFlex HS series vs Nutanix Acropolis AOS Cisco HyperFlex gives extended hyper-convergence functions from core to edge and multi-cloud environments. It helps IT and OT teams deploy hyper...
See all answers
How does VxRail compare with Cisco HyperFlex HX Series?
VxRail provides stable solutions for technical problems while at the same time not being too expensive for a company to invest in. Even if you are working with a limited budget, this platform offer...
See all answers
What do you like most about Cisco HyperFlex HX-Series?
It's easy to get the tool started.
See all answers
What is the biggest difference between Nutanix Acropolis and VMware vSphere?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
See all answers
Which would you choose - Nutanix Acropolis AOS or VMware vSAN?
We found the reduced power consumption with Nutanix Acropolis AOS a very attractive feature. We also like the interface that allows you to talk directly to your VM from the present software. We fou...
See all answers
What makes Nutanix Cloud Infrastructure (NCI) worth using?
NCI is a product with many tools and services but the one that, in my opinion, makes it better than similar products and worth using, is the full-stack lifecycle management. This capacity allows u...
See all answers
 

Comparisons

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HPE SimpliVity vs Cisco HyperFlex HX-Series [EOL]
Compared 62% of the time
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VxRail vs Nutanix Cloud Infrastructure (NCI) Logo
VxRail vs Nutanix Cloud Infrastructure (NCI)
Compared 7% of the time
Azure Stack HCI vs Nutanix Cloud Infrastructure (NCI) Logo
Azure Stack HCI vs Nutanix Cloud Infrastructure (NCI)
Compared 7% of the time
Sangfor HCI - Hyper Converged Infrastructure vs Nutanix Cloud Infrastructure (NCI) Logo
Sangfor HCI - Hyper Converged Infrastructure vs Nutanix Cloud Infrastructure (NCI)
Compared 7% of the time
HPE SimpliVity vs Nutanix Cloud Infrastructure (NCI) Logo
HPE SimpliVity vs Nutanix Cloud Infrastructure (NCI)
Compared 6% of the time
VMware vSAN vs Nutanix Cloud Infrastructure (NCI) Logo
VMware vSAN vs Nutanix Cloud Infrastructure (NCI)
Compared 6% of the time
More Nutanix Cloud Infrastructure (NCI) Competitors
 

Product Reports

Buyer's Guide
Cisco HyperFlex HX-Series [EOL]
September 2025
Cisco HyperFlex HX-Series [EOL] reportDownload Cisco HyperFlex HX-Series [EOL] product report
Buyer's Guide
Nutanix Cloud Infrastructure (NCI)
August 2025
Nutanix Cloud Infrastructure (NCI) reportDownload Nutanix Cloud Infrastructure (NCI) product report
 

Also Known As

No data available
Nutanix Acropolis AOS, Nutanix AOS, Nutanix Acropolis
 

Overview

The Cisco HyperFlex HX Data Platform is a purpose-built, high-performance, scale-out file system with a wide array of enterprise-class data management services. The data platform’s innovations redefine distributed storage technology, giving you complete hyper-convergence with enterprise storage features:

  • Enterprise-class data management
  • Continuous data optimization
  • Securely encrypted storage
  • Dynamic data placement
  • Clusterwide parallel data distribution
  • Linear and incremental scaling
  • API-based data platform architecture
  • A simplified approach
Cisco

Nutanix Cloud Infrastructure (NCI) is a top-ranking HCI software, cloud management tool, and Software Defined Storage (SDS) tool that is marketed as the foundation for users' hybrid clouds. It offers a powerful and secure hyperconverged infrastructure to deliver all data and applications at any scale and on any cloud. The solution offers a complete software stack that allows users to unify their hybrid cloud infrastructure. 

NCI’s services include computer, storage and network, hypervisors and containers, and deployment in public or in private clouds. The product also comes with built-in resilience, disaster recovery capabilities, self-healing, and high-security capacities. It provides further deployment flexibility through several software and hardware options and platforms. NCI includes a full set of enterprise capabilities. It can also be deployed on a wide range of servers from popular manufacturers.

The capabilities of the product are categorized into three main groups:

  • AOS storage
  • Flexible and open compute
  • Automated and secure networking

Outside of these categories, NCI also offers other capabilities:

  • Integrated disaster recovery
  • Full-stack lifecycle management
  • VMware with Nutanix
  • Intelligent operations

Nutanix Cloud Infrastructure (NCI) Features

Nutanix Cloud Infrastructure (NCI) offers its customers various features and tools in each of the previously mentioned categories. The available features for users currently include:

  • High-performance: This set of features utilizes hardware advances such as NVMe and RDMA to accelerate users' most demanding applications with consistent performance. The tools in this feature category work alongside data locality to ensure successful results.

  • Foolproof resiliency: These Nutanix Cloud Infrastructure features protect data and keep it available by facilitating advanced distributed consistency algorithms. Users can utilize these features to protect their data from issues like bit rot, hardware failures, and even entire site failure.

  • Flexibility: This set of features allows storage to be sized for the needs of each organization and expanded promptly and easily so that the organization and its data can grow. The features offer flexibility to users in terms of applying storage policies logically on a pre-workload basis, instead of being tied to hardware.

  • Hypervisor choice: Users can choose from the leading hypervisors - Microsoft Hyper-V or VMware ESXi. They can also leverage the built-in hypervisor AHV that Nutanix Cloud Infrastructure (NCI) provides.

  • Integrated virtualization: These features offer simplified automation and AHV streamlined operations. The services in this category are optimized for high performance and reliability.

  • Kubernetes: Nutanix Cloud Infrastructure (NCI) offers features to build and deploy cloud-native applications on intelligent distributed infrastructure. Apps can be integrated with cloud-compatible storage and both building and deployment can be achieved within the same platform.

  • Microsegmentation: Nutanix Cloud Infrastructure (NCI) offers features to prevent malware spread and reduce attack surfaces by leveraging machine learning (ML).

  • Virtual networking: This set of features allows users to easily implement multi-tenancy in their environment or stretch networks across clouds.

  • Centralized network management: Nutanix Cloud Infrastructure (NCI) provides organizations with a way to manage networking configurations centrally. Users can utilize it across their human-computer interaction (HCI) environment with simple virtual switch management.

Nutanix Cloud Infrastructure (NCI) Benefits

The product offers various benefits to users who utilize its capacities. Some of these include:

  • NCI reduces technology sprawl and frees up technical resources to allow organizations to focus on other activities, potentially reducing costs for the business.

  • The product allows customers to deploy, scale, and bridge to the public cloud to be able to react in evolving business environments.

  • Nutanix Cloud Infrastructure improves data availability while simultaneously protecting it against several kinds of failures and attacks.

  • The solution offers high-performance, resilient distributed storage for all workloads.

  • Working alongside Nutanix Cloud Platform, NCI offers simple management of data from one console.

  • Nutanix Cloud Infrastructure works by the zero trust philosophy, protecting users' apps and data through specially designed security protocols.

Reviews from Real Users

According to Gerhard J., an IT manager at Q4 Fuel, Nutanix Cloud Infrastructure (NCI) provides serious reliability and stability across the entire system makes for ROI.

A solutions architect at a computer software company describes NCI as a stable, straightforward to set up, and scalable solution.

Nutanix
 

Sample Customers

BluePearl Veterinary Partners, Ready Pac Foods, Bryant University, Bellevue Group, KPIT Technologies, City Harvest
St. Lukes Health System, the City of Seattle, Yahoo! Japan, Sligro, Empire Life, Hyundai AUS, and many others.
Buyer's Guide
HCI
September 2025
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