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Proofpoint Targeted Attack Protection vs Trellix Advanced Threat Defense comparison

Proofpoint and Trellix are both solutions in the Advanced Threat Protection (ATP) category. Proofpoint is ranked #30, while Trellix is ranked #21 with an average rating of 9.0. Proofpoint holds a 1.7% mindshare in ATP, compared to Trellix’s 2.0% mindshare. Additionally, 100% of Proofpoint users are willing to recommend the solution, compared to 76% of Trellix users who would recommend it.
Proofpoint Targeted Attack ...
Read 1 Proofpoint Targeted Attack Protection review
  • 416 Views
  • 333 Comparison Views
100% willing to recommend
Trellix Advanced Threat Def...
Read 9 Trellix Advanced Threat Defense reviews
  • 416 Views
  • 379 Comparison Views
76% willing to recommend
 

Comparison Buyer's Guide

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Executive Summary
We performed a comparison between Proofpoint Targeted Attack Protection and Trellix Advanced Threat Defense based on real PeerSpot user reviews.

Find out what your peers are saying about Palo Alto Networks, Microsoft, Fortinet and others in Advanced Threat Protection (ATP).

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To learn more, read our detailed Advanced Threat Protection (ATP) Report (Updated: October 2025).
Buyer's Guide
Advanced Threat Protection (ATP)
October 2025
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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Proofpoint Targeted Attack ...
Ranking in Advanced Threat Protection (ATP)
30th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
1
Ranking in other categories
No ranking in other categories
Trellix Advanced Threat Def...
Ranking in Advanced Threat Protection (ATP)
21st
Average Rating
7.8
Reviews Sentiment
5.6
Number of Reviews
9
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of October 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Proofpoint Targeted Attack Protection is 1.7%, down from 2.3% compared to the previous year. The mindshare of Trellix Advanced Threat Defense is 2.0%, up from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Trellix Advanced Threat Defense2.0%
Proofpoint Targeted Attack Protection1.7%
Other96.3%
Advanced Threat Protection (ATP)
 

Featured Reviews

KC
Dynamic runtime engine and good protection, but needs better support and a single console
We have two to three issues per month. We contact Proofpoint's customer support for these issues. I am a major point of contact for support. If I am not able to resolve an issue, we will be reaching out to them. Proofpoint can take a couple of days to get back. I also deal with other applications from Okta and Microsoft, and we get the support within a couple of hours. There is a lot of difference between a couple of hours and a couple of days. So, Proofpoint's support should be improved. Okta and Microsoft are also able to do a Zoom or video call, but Proofpoint provides support only through email communication. Only if you request, it would be a Zoom or video session.
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PP
Ensuring long-term reliability while seeking internal email management enhancements
Prisma is a commercial name of the firewall now, but we don't work with the cloud product. Only our company is using it and we do not recommend it to customers. For us, it's transparent because it's a cloud product, so we don't really know the version as it's always updated. We have not had any problem, but it's difficult to report on what's going on because some days they can wash out perhaps 100 mails, and then it's difficult to say how many attacks you have reached. The right email has been washed out and then nobody has complained. We do not use the Threat Visualization feature; as we are in MX, the mail is washed out before it is in the mail inbox of the user, thus avoiding any problem requiring a reservation. In fact, there is no integration with existing security frameworks. The only problem we can have is that as we have no API interface, there is no inspection of internal mail. I rate Trellix Advanced Threat Defense a nine out of ten.
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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"It has a dynamic runtime engine, which gives it an advantage over Prisma that has a static engine. In Prisma, we have to do additional malware analysis, which is not required in Proofpoint."
"It stops in excess of twenty-five malware events per month, all of which could be critical to the business."
"It is very scalable."
"The fact that in 10 years, we have had no problem is the most valuable feature for us; it's really a washing machine, but the only problem we face is that it's difficult to report on this product."
"The most valuable features are the administration console and its detection and response module."
"It is stable and reliable."
"Its greatest strength is the DXL client which can rapidly disseminate attack information to all clients via the McAfee Agent instead of going through the ePO server."
"I recommend this solution because of its ease of use."
"Provides good exfiltration, and is an all-in-one product."
 

Cons

"We are using the TRAP console that has a Linux-based UI, which is not user-friendly. The TAP console looks very advanced. Currently, we are maintaining three different consoles, and it is sometimes hard to switch between them or try to grab the data."
"There could be a tool that automatically updates all-new Microsoft IPs, which are available for free to connect to the client."
"Make the ATD system a part of the whole product and take the whole thing onto the cloud. While it is there already, it is not to the same level as the on-premise version."
"The only problem we can have is that as we have no API interface, there is no inspection of internal mail."
"Lacks remote capabilities not dependent on the internet."
"The initial setup was industry standard complex. It takes awhile and has a lot of planning involved. It could be simplified with product redesign."
"We'd like them to be better at dealing with script threats."
"This solution needs to be made "cloud ready"."
"I would like to see future versions of the solution incorporate artificial intelligence technology."
 

Pricing and Cost Advice

Information not available
"The product is expensive, but it is better than the rest of them in the industry."
"Our licensing fees for this solution are approximately one million dollars per year."
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Top Industries

By visitors reading reviews
Manufacturing Company
10%
Healthcare Company
8%
Computer Software Company
6%
Transportation Company
6%
Government
16%
Comms Service Provider
15%
Performing Arts
11%
Financial Services Firm
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
No data available
By reviewers
Company SizeCount
Small Business3
Midsize Enterprise4
Large Enterprise5
 

Questions from the Community

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What do you like most about McAfee Advanced Threat Defense?
I recommend this solution because of its ease of use.
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What needs improvement with McAfee Advanced Threat Defense?
I would like to see an API interface for internal email and control of outgoing email to make it closer to 10. It's necessary; today we have an MX interface, and it would be interesting to have an ...
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What is your primary use case for McAfee Advanced Threat Defense?
We are working with Palo Alto products, specifically firewalls. We are only using Palo Alto Firewalls and not Cortex. With FireEye and Trellix, we only work with ETP now because the NDR function wh...
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Comparisons

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Microsoft Defender for Office 365 vs Proofpoint Targeted Attack Protection
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IRONSCALES vs Proofpoint Targeted Attack Protection Logo
IRONSCALES vs Proofpoint Targeted Attack Protection
Compared 29% of the time
Bitdefender Sandbox Analyzer vs Proofpoint Targeted Attack Protection Logo
Bitdefender Sandbox Analyzer vs Proofpoint Targeted Attack Protection
Compared 21% of the time
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Fortinet FortiSandbox vs Trellix Advanced Threat Defense Logo
Fortinet FortiSandbox vs Trellix Advanced Threat Defense
Compared 34% of the time
Check Point Infinity vs Trellix Advanced Threat Defense Logo
Check Point Infinity vs Trellix Advanced Threat Defense
Compared 23% of the time
Microsoft Defender for Identity vs Trellix Advanced Threat Defense Logo
Microsoft Defender for Identity vs Trellix Advanced Threat Defense
Compared 23% of the time
Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense Logo
Microsoft Defender for Office 365 vs Trellix Advanced Threat Defense
Compared 20% of the time
More Trellix Advanced Threat Defense Competitors
 

Product Reports

Buyer's Guide
Advanced Threat Protection (ATP)
October 2025
Proofpoint Targeted Attack Protection reportDownload Proofpoint Targeted Attack Protection product report
Buyer's Guide
Trellix Advanced Threat Defense
October 2025
Trellix Advanced Threat Defense reportDownload Trellix Advanced Threat Defense product report
 

Also Known As

Targeted Attack Protection
McAfee Advanced Threat Defense
 

Overview

More than 90% of targeted attacks start with email—and these threats are always evolving. Proofpoint Targeted Attack Protection (TAP) helps you stay ahead of attackers with an innovative approach that detects, analyzes and blocks advanced threats before they reach your inbox. This includes ransomware and other advanced email threats delivered through malicious attachments and URLs. And zero-day threats, polymorphic malware, weaponized documents and phishing attacks. TAP provides adaptive controls to isolate the riskiest URL clicks. TAP also detects threats and risks in cloud apps, connecting email attacks related to credential theft or other attacks.

Proofpoint

Powerful advanced threat detection

Uncover Hidden Threats

Combine in-depth static code analysis, dynamic analysis (malware sandboxing), and machine learning to increase zero-day threat and ransomware detection.

Threat Intelligence Sharing

Immediately share threat intelligence across your entire infrastructure—including multi-vendor ecosystems—to reduce time from threat encounter to containment.

Enable Investigation

Validate threats and access critical indicators of compromise (IoCs) needed for investigation and threat hunting.

Trellix
 

Sample Customers

Brinker Capital
The Radicati Group, Florida International University, MGM Resorts International, County Durham andDarlington NHS Foundation Trust
Buyer's Guide
Advanced Threat Protection (ATP)
October 2025
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