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Microsoft Defender for Office 365 vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
6.9
Microsoft Defender for Office 365 offers strong ROI through security enhancements, cost savings, and improved company productivity despite measurement challenges.
Sentiment score
5.7
Palo Alto Networks VM-Series delivers strong ROI through enhanced security, rapid deployment, and significant time savings despite high pricing.
It has also decreased our time to detection and response by about 15 to 20 percent.
Technology support manager at Alfred State College
Overall, cost of owning and operating our system goes down.
Designation Chief Consultant at Avtow
It's hard to quantify the return on investment we've seen from Microsoft Defender for Office 365.
Chief Architect at a tech vendor with 1,001-5,000 employees
Customers can see data within a week, indicating a quick return on investment.
Senior Manager Technical Security at Hitachi Systems, Ltd.
 

Customer Service

Sentiment score
5.8
Microsoft Defender for Office 365 users rate support highly, praising its responsiveness and 24/7 availability, despite occasional documentation and communication issues.
Sentiment score
7.5
Customers appreciate Palo Alto Networks VM-Series support for responsiveness and expertise, despite occasional delays and high premium service costs.
Over the past two years, there have been no critical problems.
Solution Consultant at BIM Group of Companies
we opened tickets, and they typically resolve them quickly.
Chief Architect at a tech vendor with 1,001-5,000 employees
With a subscription for Microsoft Defender for Office 365, it is an eight. Without it, it is a six.
Manager at a tech services company with 10,001+ employees
The support quality could be improved.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Resolving issues promptly.
Head of Sales at Omgea Exim Ltd
They are responsive and provide high-quality assistance.
Cyber security consultant at L&T Technology Services
 

Scalability Issues

Sentiment score
7.8
Microsoft Defender for Office 365 offers scalable, efficient protection for large enterprises, ensuring seamless growth across diverse industries.
Sentiment score
7.4
Palo Alto Networks VM-Series is scalable, easy to deploy, and suits businesses with positive feedback on flexibility and growth.
We have never faced scalability problems, and Microsoft manages it effectively.
Solution Consultant at BIM Group of Companies
Microsoft Defender for Office 365 scales transparently for us, as we grew from 1,000 users to 3,000 users, and we didn't notice much difference.
Chief Architect at a tech vendor with 1,001-5,000 employees
Microsoft Defender for Office 365 scales with the growing needs of my company well.
Senior Client Director and Advisory Service Leader at Crossfuze
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
Security Technical Lead at a tech services company with 11-50 employees
The solution is scalable and can easily handle an increase in the number of users.
Cyber security consultant at L&T Technology Services
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
Senior Security Consultant at Netsecurity.no
 

Stability Issues

Sentiment score
7.7
Microsoft Defender for Office 365 provides 99.9% uptime with minor issues, ensuring reliable performance and seamless cloud integration.
Sentiment score
8.2
Palo Alto Networks VM-Series is highly regarded for stability, reliable performance, and consistent uptime, despite minor navigation delays.
I would rate the stability of Microsoft Defender for Office 365 as 10 over 10 because it's highly available, it works, and it does the job it is meant to do.
Cloud Solutions Architect at a tech services company with 201-500 employees
I have not experienced any downtime, crashes, or performance issues because of Defender.
Technology Associate at a financial services firm with 51-200 employees
The solution is stable, as we have been using it for the past two years.
Solution Consultant at BIM Group of Companies
Hardware is generally very stable.
Security Technical Lead at a tech services company with 11-50 employees
I have not experienced any major problems or downtime.
Senior IT Infrastructure Specialist at contemi
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
Senior Security Consultant at Netsecurity.no
 

Room For Improvement

Users call for enhanced virus detection, cross-platform support, and pricing transparency in Microsoft Defender for Office 365.
Palo Alto Networks VM-Series needs UI updates, better platform integration, scalability, user-friendliness, and improved documentation for broader efficiency.
The main area for improvement is simplifying the implementation and rollout process.
Infrastructure and Security Lead at Vedanta
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
Solution Consultant at BIM Group of Companies
There is a different console for different things; I just want one consolidated console.
Senior Director, Security Architecture & Engineering at a leisure / travel company with 10,001+ employees
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Cyber security consultant at L&T Technology Services
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
Security Technical Lead at a tech services company with 11-50 employees
Having those features missing, we are not proposing Palo Alto Networks VM-Series to all customers.
Sr. Network Engineer at a tech services company with 1-10 employees
 

Setup Cost

Microsoft Defender for Office 365 pricing is seen as flexible but potentially expensive, offering value in comprehensive security features.
Palo Alto VM-Series is costly but reliable, with complex licensing; AWS Marketplace offers scalable subscription options.
We've likely saved 30% of costs.
Designation Chief Consultant at Avtow
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Infrastructure and Security Lead at Vedanta
Microsoft is quite affordable with a lot of features available for any size organization.
Solution Consultant at BIM Group of Companies
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
Security Technical Lead at a tech services company with 11-50 employees
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Senior IT Infrastructure Specialist at contemi
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
Head of Sales at Omgea Exim Ltd
 

Valuable Features

Microsoft Defender for Office 365 enhances email security with anti-phishing, anti-malware, threat intelligence, and seamless integration for efficient management.
The VM-Series provides scalable, flexible security with advanced threat management, visibility, and integration features, enhancing network protection.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
Technology support manager at Alfred State College
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
Solution Consultant at BIM Group of Companies
The value of the DLP feature is significant to us because we have internal data, sometimes sensitive, and the users may not always be aware of security and privacy, which might lead them to send out information mistakenly to external parties.
Chief Architect at a tech vendor with 1,001-5,000 employees
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Senior Manager Technical Security at Hitachi Systems, Ltd.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
Security Technical Lead at a tech services company with 11-50 employees
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
Senior Security Consultant at Netsecurity.no
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
60
Ranking in other categories
Email Archiving (1st), Email Security (1st), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
9th
Average Rating
8.6
Reviews Sentiment
6.9
Number of Reviews
66
Ranking in other categories
Firewalls (13th)
 

Mindshare comparison

As of December 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 6.8%, down from 11.7% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.9%, up from 1.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
Microsoft Defender for Office 3656.8%
Palo Alto Networks VM-Series2.9%
Other90.3%
Advanced Threat Protection (ATP)
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
AV
Cyber security consultant at L&T Technology Services
Enhance cybersecurity for large enterprises using advanced threat management
An improvement could be the integration of security intelligence with Palo Alto cloud via APIs. This would allow IOCs, domains, and hash values to be automatically entered, reducing manual entry. Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
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Use our free recommendation engine to learn which Advanced Threat Protection (ATP) solutions are best for your needs.
879,371 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
15%
Financial Services Firm
8%
Manufacturing Company
8%
Comms Service Provider
6%
Computer Software Company
12%
Manufacturing Company
10%
Financial Services Firm
10%
University
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise10
Large Enterprise31
By reviewers
Company SizeCount
Small Business29
Midsize Enterprise17
Large Enterprise24
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What needs improvement with Microsoft Defender for Office 365?
The inbuilt analysis of false positives can be faster. It's not slow, but it can be faster.
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

MS Defender for Office 365
No data available
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Palo Alto Networks VM-Series and other solutions. Updated: December 2025.
879,371 professionals have used our research since 2012.