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Microsoft Defender for Office 365 vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Organizations saw increased productivity, cost savings, and enhanced security with Microsoft Defender for Office 365's advanced features.
Sentiment score
7.1
Palo Alto Networks VM-Series offers high ROI with efficient deployment, enhanced security, and significant time and effort savings.
It has also decreased our time to detection and response by about 15 to 20 percent.
Customers can see data within a week, indicating a quick return on investment.
 

Customer Service

Sentiment score
6.9
Microsoft Defender for Office 365 support is praised for responsiveness but has inconsistencies, especially in first-level assistance.
Sentiment score
7.6
Palo Alto Networks VM-Series support is generally responsive and effective, but some users note delays and inefficiencies.
Over the past two years, there have been no critical problems.
Customer service and support have been fantastic.
The support quality could be improved.
Resolving issues promptly.
They are responsive and provide high-quality assistance.
 

Scalability Issues

Sentiment score
8.1
Microsoft Defender for Office 365 scales effectively, seamlessly expanding capacity with minimal maintenance, suitable for large and growing organizations.
Sentiment score
7.6
Palo Alto Networks VM-Series is scalable with praised deployment and licensing, but faces integration and cost management challenges.
We have never faced scalability problems, and Microsoft manages it effectively.
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
The solution is scalable and can easily handle an increase in the number of users.
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
 

Stability Issues

Sentiment score
7.7
Microsoft Defender for Office 365 is reliable, with 99.9% availability and efficient bug fixes, offering seamless performance and stability.
Sentiment score
8.3
Palo Alto Networks VM-Series is highly stable, reliable, and performs excellently, though occasional update and API delays are reported.
The solution is stable, as we have been using it for the past two years.
Hardware is generally very stable.
I have not experienced any major problems or downtime.
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
 

Room For Improvement

Microsoft Defender for Office 365 needs enhanced threat detection, integration, support, usability, documentation, and transparent pricing to address customer concerns.
Palo Alto Networks VM-Series could improve usability and integration by adopting HTML5, enhancing features, and addressing cost and support issues.
The main area for improvement is simplifying the implementation and rollout process.
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
I would reduce the cost.
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
When managing the firewall, it involves a Strata Cloud web browser that requires improvement to enhance deployment ease and call center efficiency.
 

Setup Cost

Microsoft Defender for Office 365, often pricey for SMEs, offers extensive security features with complex user-based licensing.
Palo Alto Networks VM-Series pricing is high, complex, and costly compared to Fortinet and Check Point alternatives.
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Microsoft is quite affordable with a lot of features available for any size organization.
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
 

Valuable Features

Microsoft Defender for Office 365 offers integrated protection with features like anti-malware and threat detection, enhancing security through AI.
Palo Alto Networks VM-Series offers superior threat management, scalability, advanced security features, and ease, making it a preferred cybersecurity choice.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
Microsoft Defender for Office 365 is now part of a centralized tenant for my entire group.
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
49
Ranking in other categories
Email Security (1st), Microsoft Security Suite (11th)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
9th
Average Rating
8.6
Reviews Sentiment
7.1
Number of Reviews
64
Ranking in other categories
Firewalls (11th)
 

Mindshare comparison

As of May 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.8%, down from 14.2% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.1%, up from 0.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
AshwaniTyagi - PeerSpot reviewer
Advanced protection and good integration capabilities with good reliability
We use Palo Alto Networks VM-Series to offer services to our customers as a managed security service provider. We provide solutions and services to our customers across the globe. For example, if I want to host a firewall in the cloud or somewhere where the physical appliance is not a possibility…
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
17%
Financial Services Firm
14%
Manufacturing Company
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Money-wise, it is a part of the Office 365 ( /products/office-365-reviews ) suite, making it slightly more expensive compared to Trend Micro. Although Defender is free, you have to pay separately f...
What needs improvement with Microsoft Defender for Office 365?
The main area for improvement is simplifying the implementation and rollout process. There are many conditions to be met, making it challenging to ensure every system is protected. Troubleshooting ...
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

MS Defender for Office 365
No data available
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Palo Alto Networks VM-Series and other solutions. Updated: April 2025.
850,028 professionals have used our research since 2012.