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Microsoft Defender for Office 365 vs Trend Micro InterScan Messaging Security [EOL] comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Jun 3, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (2nd), Email Security (2nd), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
Trend Micro InterScan Messa...
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
3
Ranking in other categories
No ranking in other categories
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
Abdul  Waris - PeerSpot reviewer
Tech Operations at Martin Dow Limited
Deploy features like DLP and BEC for enhanced security
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement With Trend Micro email security gateway, we can deploy features like DLP and BEC. It includes Office 365 protection and sandboxing. This provides…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Defender for Office 365 has helped eliminate having to look at multiple dashboards and that is the aspect I like most about it. It is simpler, effective, and convenient. The users like the process efficiency."
"The insights provided with Microsoft Defender for Office 365 are helpful because it comes with the E5 license, and by default, we can use a lot of capabilities."
"It has significantly decreased my time to detection and response."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the individuals within our organization who are affected."
"The technical support is good and quick to resolve issues."
"Microsoft Defender for Office 365 saves me time; it does save a lot of time, especially with the automation."
"The most valuable feature of Microsoft Defender for Office 365 is its spam filter."
"The technical support services are excellent."
"With Trend Micro email security gateway, we can deploy features like DLP and BEC."
"The solution provides protection with its Email Track Records and Machine Manual features."
 

Cons

"Microsoft needs to broaden its global support presence by establishing teams of subject-matter experts in all regions."
"We are always looking for others tools to increase automation on tasks. There can be better integration with other solutions, such as PowerPoint and email."
"I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"To improve Microsoft Defender for Office 365, it would be nice to have more accessibility for users to see on their end what they are doing that could cause a threat."
"The pre-sales cost calculations could be more transparent."
"Configuration requires going to a lot of places rather than just accessing one tab."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"The product's pricing could be more flexible."
"The solution's pricing could be improved."
"There is room for improvement in content filtration, expressions, file sharing, and policy configuration."
 

Pricing and Cost Advice

"Compared to other brands, Microsoft Defender for Office 365's pricing is competitive."
"The pricing is normal. Considering its popularity, it's not overpriced."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"The license is expensive because the cost is based on the number of users."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"It's a user-base subscription."
"The product is very expensive."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"Trend Micro is an expensive solution."
"I rate Trend Micro InterScan Messaging Security’s pricing a seven out of ten."
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920,223 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Computer Software Company
11%
Manufacturing Company
10%
Financial Services Firm
8%
Comms Service Provider
7%
Performing Arts
16%
Construction Company
10%
Manufacturing Company
9%
Outsourcing Company
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
No data available
 

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitors are ch...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
What is your experience regarding pricing and costs for Trend Micro InterScan Messaging Security?
The price is a bit high because the market is highly competitive. Multiple platforms are available, so we have to choose based on comparison.
What needs improvement with Trend Micro InterScan Messaging Security?
There is room for improvement in content filtration, expressions, file sharing, and policy configuration. We could decrease the price in email security gateway and cloud security services.
What is your primary use case for Trend Micro InterScan Messaging Security?
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement.
 

Also Known As

MS Defender for Office 365
InterScan Messaging Security
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Copa Airlines, Air21, BookMyShow, Bulgarian American Credit Bank, Canadian Museum of History, CIBIL, Community National Bank, Dar Al-Handasah
Find out what your peers are saying about Proofpoint, Microsoft, Check Point Software Technologies and others in Email Security. Updated: October 2026.
920,223 professionals have used our research since 2012.