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Cisco Secure Email Threat Defense vs MetaDefender Email Gateway Security comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Oct 6, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
22nd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
MetaDefender Email Gateway ...
Ranking in Email Security
32nd
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
3
Ranking in other categories
Secure Email Gateway (SEG) (12th)
 

Mindshare comparison

As of November 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of MetaDefender Email Gateway Security is 1.2%, up from 0.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Cisco Secure Email Threat Defense1.1%
MetaDefender Email Gateway Security1.2%
Other97.7%
Email Security
 

Featured Reviews

GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
RM
Senior Information Systems Engineer at Liberty Pumps, Inc.
Helpful support, and useful dashboards
They offer a feature called SmartLink neutralization. I have tried it before. It seemed to work most of the time; however, I had a few users for whom it just wouldn't work. Whenever they click on a link, it stays on the MetaDefender page, saying that it's scanning it and never moves forward. I haven't tried it in a while since then. Since I can't turn it off on a per-user basis, I had to turn it off globally. I have certain exceptions for not doing the sanitization, and how to set those up is not intuitive. It would be useful if there were a better way of doing that. Using digital certificates is hard. It would be better if it used Windows Servers' built-in certificate management.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"It has an efficient email filtering feature."
"The advanced threat analytics and URL filtering in threat detection are good features that are working well."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"The features and functionalities are much better than Microsoft's in-built Defender plan, and this product has helped us to protect our organization from any malware attack in the past."
"The product offers protection, email security, anti-spam, and antivirus."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"Cisco Secure Email Threat Defense's best features include user management of graymail, enhancing security awareness by allowing users to manage cold calls, sales-based items, and ensuring email compliance."
"The most valuable feature of MetaDefender Email Security is the CDR. Customers purchase this solution specifically for data communication, as the other features can be obtained through other technologies that most customers already possess. Therefore, data communication serves as the foundation for the platform."
"The most valuable feature is called summary reconstruction which is used to deliver encrypted files to users."
"The sanitization is very good."
 

Cons

"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"This solution could be improved by integration with Sandbox."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"We encounter issues while searching for missing emails."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"The learning curve shows that in the beginning, there are numerous false positives. For one month, we had to reclassify the false positives manually until the system learned."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"They offer a feature called SmartLink neutralization. I have tried it before. It seemed to work most of the time; however, I had a few users for whom it just wouldn't work. Whenever they click on a link, it stays on the MetaDefender page, saying that it's scanning it and never moves forward."
"The DLP should be upgraded and has room for improvement."
"Although the number of AV engines is good, it could be better."
 

Pricing and Cost Advice

"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"According to our customers, the price of MetaDefender is high and it continues to increase by almost 15 percent each year."
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921,523 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
9%
Healthcare Company
9%
Outsourcing Company
13%
Construction Company
12%
Comms Service Provider
9%
University
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
No data available
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
Ask a question
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Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
OPSWAT MetaDefender Email Security, MetaDefender Email Gateway Security, MetaDefender Email Security
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
https://www.opswat.com/blog/how-one-of-the-largest-banks-in-taiwan-uses-opswat-metadefender-email-security-to-close-security-gaps https://www.opswat.com/blog/hapool-insurance-achieves-almost-100-reduction-in-email-threats-with-opswat https://www.opswat.com/blog/luzerner-psychiatrie-ag-stops-email-borne-malware-attacks-with-opswat-technology
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. MetaDefender Email Gateway Security and other solutions. Updated: November 2026.
921,523 professionals have used our research since 2012.