On the platform that I work on, it is the sole database package, and there's a whole lot of production going on every day: many transactions, many online users, batch, etc., accessing the database.
We've had it for so long, so it's status quo. But we've added all sorts of functionality to our applications and there are no issues with databases. Anything developers request, we're able to accomplish.
Also, we deal a lot with government regulation - and not to talk about what the company does - but anything that they require of us, because we transmit data back and forth with them, we're able to do that with no problems. And there have been a lot of changes over the past five years that our government dictated regarding what we actually end up doing. So, we're able to be extremely flexible with that.