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Microsoft Defender for Endpoint vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.3
Microsoft Defender for Endpoint offers cost savings, enhanced protection, and efficient threat management, with anticipated future benefits.
Sentiment score
7.1
Palo Alto Networks VM-Series offers high ROI with efficient deployment, enhanced security, and significant time and effort savings.
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
The return on investment is primarily in time savings and better observability of what's happening.
Customers can see data within a week, indicating a quick return on investment.
 

Customer Service

Sentiment score
6.5
Support for Microsoft Defender for Endpoint varies, with premium tiers offering quicker responses, while basic support can be slow.
Sentiment score
7.6
Palo Alto Networks VM-Series support is generally responsive and effective, but some users note delays and inefficiencies.
The level-one support seems disconnected from subject matter experts.
I rate Microsoft support 10 out of 10.
Due to our size, we don't have access to direct technical support, but the knowledge base, Microsoft Learn, and the articles available are really good.
The support quality could be improved.
Resolving issues promptly.
They are responsive and provide high-quality assistance.
 

Scalability Issues

Sentiment score
7.7
Microsoft Defender for Endpoint is a scalable solution integrating smoothly with Microsoft, ideal for diverse organizational needs and configurations.
Sentiment score
7.6
Palo Alto Networks VM-Series is scalable with praised deployment and licensing, but faces integration and cost management challenges.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Compatibility is its main feature.
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
The solution is scalable and can easily handle an increase in the number of users.
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is stable and reliable, with integration ease, despite occasional lags and minor update bugs.
Sentiment score
8.3
Palo Alto Networks VM-Series is highly stable, reliable, and performs excellently, though occasional update and API delays are reported.
I haven't seen any outages with Microsoft.
I rate Defender 10 out of 10 for stability.
Defender for Endpoint is extremely stable.
Hardware is generally very stable.
I have not experienced any major problems or downtime.
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
 

Room For Improvement

Microsoft Defender for Endpoint needs frequent updates, improved integration, user-friendly interface, enhanced analytics, and better support documentation.
Palo Alto Networks VM-Series could improve usability and integration by adopting HTML5, enhancing features, and addressing cost and support issues.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Providing more detailed information on how Microsoft Defender for Endpoint detects vulnerabilities.
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
When managing the firewall, it involves a Strata Cloud web browser that requires improvement to enhance deployment ease and call center efficiency.
 

Setup Cost

Microsoft Defender for Endpoint is cost-effective with bundled licenses, but advanced features may incur additional fees.
Palo Alto Networks VM-Series pricing is high, complex, and costly compared to Fortinet and Check Point alternatives.
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
The pricing, setup, and licensing were very easy and simple.
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
 

Valuable Features

Microsoft Defender for Endpoint offers seamless integration, real-time threat detection, and efficient management, enhancing security with minimal system impact.
Palo Alto Networks VM-Series offers superior threat management, scalability, advanced security features, and ease, making it a preferred cybersecurity choice.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
Web filtering is the most valuable feature of Microsoft Defender for Endpoint because it effectively maintains security for website access.
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
2nd
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
194
Ranking in other categories
Endpoint Protection Platform (EPP) (1st), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (5th)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
9th
Average Rating
8.6
Reviews Sentiment
7.1
Number of Reviews
64
Ranking in other categories
Firewalls (11th)
 

Mindshare comparison

As of May 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 9.2%, down from 11.4% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.1%, up from 0.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

AnuragSrivastava - PeerSpot reviewer
Provides detailed visibility into threats but the ability to add exceptions needs improvement
One major item for improvement is the ability to add exceptions. We can add some exceptions, but not at the level we need to. The second major area for improvement involves enhanced capabilities for different operating systems or platforms. That is, even though we have coverage for different operating systems or platforms such as Linux, we don't get all of the controls and enhanced capabilities that are available with Windows devices. Reporting could also be improved because, at present, we get limited results at times. For example, in an environment with more than 100,000 devices, you may just get 10,000 results when you run a report.
AshwaniTyagi - PeerSpot reviewer
Advanced protection and good integration capabilities with good reliability
We use Palo Alto Networks VM-Series to offer services to our customers as a managed security service provider. We provide solutions and services to our customers across the globe. For example, if I want to host a firewall in the cloud or somewhere where the physical appliance is not a possibility…
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Top Industries

By visitors reading reviews
Educational Organization
25%
Computer Software Company
11%
Government
7%
Financial Services Firm
7%
Computer Software Company
16%
Financial Services Firm
13%
Manufacturing Company
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
No data available
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Palo Alto Networks VM-Series and other solutions. Updated: April 2025.
849,963 professionals have used our research since 2012.