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Microsoft Defender for Endpoint vs Palo Alto Networks VM-Series comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Dec 1, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.3
Organizations achieve financial gains and efficiency by using Microsoft Defender, eliminating third-party solutions, and enhancing security management.
Sentiment score
7.1
Palo Alto Networks VM-Series offers strong ROI with enhanced security, increased agility, and significant time savings for users.
Without detection and protection measures, organizations would face substantial payments and reputational damage, including the necessity to inform customers about data breaches, potentially leading to loss of business.
We have seen a return on investment when using Microsoft Defender for Endpoint, as it saves labor by reducing the need for staff to focus on it.
The biggest return on investment for me when using Microsoft Defender for Endpoint is the time saving.
Customers can see data within a week, indicating a quick return on investment.
 

Customer Service

Sentiment score
6.6
Microsoft's Defender for Endpoint support is generally effective but experiences vary; premium options offer swift, knowledgeable assistance.
Sentiment score
7.6
Palo Alto Networks VM-Series support is responsive and professional, but some users note room for improvement in efficiency.
The level-one support seems disconnected from subject matter experts.
I rate Microsoft support 10 out of 10.
Due to our size, we don't have access to direct technical support, but the knowledge base, Microsoft Learn, and the articles available are really good.
The support quality could be improved.
Resolving issues promptly.
They are responsive and provide high-quality assistance.
 

Scalability Issues

Sentiment score
7.6
Microsoft Defender for Endpoint efficiently scales with diverse enterprises, integrates seamlessly with Microsoft products, supporting growth effectively.
Sentiment score
7.6
Palo Alto Networks VM-Series is scalable, satisfying users despite some cloud integration challenges, and suitable for diverse enterprises.
We managed to scale it out in a short amount of time, with two months of planning and three months of implementation on 10,000 computers.
Microsoft Defender for Endpoint is scalable enough to handle various devices across environments, whether they are laptops, Android devices, or operating in hybrid environments.
Compatibility is its main feature.
They are easy to upgrade, and with credit licensing, they scale effectively according to demand.
The solution is scalable and can easily handle an increase in the number of users.
It is easy to use with an excellent graphical user interface and extensive documentation, which contributes to its high scalability.
 

Stability Issues

Sentiment score
7.9
Microsoft Defender for Endpoint is praised for stability, efficiency, and low resource impact, despite minor occasional bugs.
Sentiment score
8.3
Palo Alto Networks VM-Series is praised for stability and reliability, despite occasional bugs and manual interventions during upgrades.
I haven't seen any outages with Microsoft.
I rate Defender 10 out of 10 for stability.
Defender for Endpoint is extremely stable.
Hardware is generally very stable.
I have not experienced any major problems or downtime.
Perfection is unlikely as the dynamic nature of traffic and constant changes can result in occasional bugs despite regular updates.
 

Room For Improvement

Microsoft Defender for Endpoint struggles with support, integration, UI, performance issues, and lacks essential features and platform support.
Palo Alto Networks VM-Series needs better integration, scalability, documentation, cloud compatibility, and improved features to address user concerns and performance.
Repeated interactions are necessary due to Level One's lack of tools and knowledge, hindering efficient problem-solving and negatively impacting our experience with Microsoft support.
We use Microsoft partners to help govern the platform, and as part of an alliance, we want to gather data from each tenant and combine them for a complete view.
Providing more detailed information on how Microsoft Defender for Endpoint detects vulnerabilities.
Integration with CSIRT across all use levels would make it easier for administrators to stay updated on the blocked entities without manual intervention.
Most customers go for partner-enabled support, which involves multiple layers, leading to delays.
When managing the firewall, it involves a Strata Cloud web browser that requires improvement to enhance deployment ease and call center efficiency.
 

Setup Cost

Microsoft Defender for Endpoint offers cost-effective, flexible pricing options integrated with Microsoft services, including discounts for education and volume.
Palo Alto Networks' VM-Series pricing is high but justified by advanced security features, with flexible licensing aiding budget management.
Given our extensive Microsoft licensing, transitioning to Defender for Endpoint did not affect licensing costs.
It costs $15 per VM for the P2 plan, which is seen as affordable for customers.
The pricing, setup, and licensing were very easy and simple.
Palo Alto is expensive in terms of pricing, particularly when comparing features to cost.
The cost involves purchasing through a vendor, which might mark up due to the supply chain.
Pricing for Palo Alto Networks is higher than other OEMs, but considering the robustness and features, it gains customer trust.
 

Valuable Features

Microsoft Defender for Endpoint offers seamless integration, real-time protection, and automated response, ensuring robust security with minimal impact.
Palo Alto Networks VM-Series excels in threat prevention, scalability, and user-friendly management, integrating advanced security features and cloud services.
Defender for Endpoint's coverage across different platforms in our environment is pretty good. We have devices running Linux, Mac OS, Windows, iOS, and Android. It covers all of them.
Microsoft Defender for Endpoint provides a unified management interface allowing customers to manage their on-premises and hybrid infrastructures from a single pane.
One of the best features of Microsoft Defender for Endpoint is its database for identifying zero-day attacks or malware attacks.
We use these tools to prevent all known and unknown threats using Palo Alto Networks' Wildfire and other data filtering tools to gather information, analyze traffic, manage malicious traffic, and offer visibility, control, and attack prevention.
Palo Alto's robust threat intelligence supports new updates, and I can open cases directly with their Threat Intelligence team.
The DNS security significantly enhances security through visibility and detection, allowing control over crucial traffic like DNS, which is often exploited by ransomware.
 

Categories and Ranking

Microsoft Defender for Endp...
Ranking in Advanced Threat Protection (ATP)
4th
Average Rating
8.2
Reviews Sentiment
7.1
Number of Reviews
197
Ranking in other categories
Endpoint Protection Platform (EPP) (1st), Anti-Malware Tools (1st), Endpoint Detection and Response (EDR) (3rd), Microsoft Security Suite (6th)
Palo Alto Networks VM-Series
Ranking in Advanced Threat Protection (ATP)
9th
Average Rating
8.6
Reviews Sentiment
7.1
Number of Reviews
64
Ranking in other categories
Firewalls (12th)
 

Mindshare comparison

As of June 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Endpoint is 8.9%, down from 11.2% compared to the previous year. The mindshare of Palo Alto Networks VM-Series is 2.5%, up from 0.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Sudhen Swami - PeerSpot reviewer
Easy to update with good protection and a useful cloud portal
We've mainly used it for endpoints. However, we've also used it for DLP as well. We're also in the process of implementing it for cloud and identity as well. However, it's very good for endpoints, and that's our main focus. The malware protection is good. The visibility it provides is very useful. We can combine visibility with wider security features and alerts around malware, misconfiguration, or any other kinds of threats. The cloud portal is quite good. From there, we are able to see alerts and have colleagues review issues and monitor to see if any patterns arise. It's serving us quite well overall. It allows us to look at other items, like application and browser control. It helps us prioritize threats. We have a process in place now where we can review issues and remediate them effectively. We have been able to integrate a variety of Microsoft security products together. We use Azure AD, for example, and we've begun to implement DLP, among other items. We're looking at labeling and tagging and will expand into that soon. Defender has more stringent system requirements than, for example, Check Point. So when we implemented the Check Point Endpoint agent, that solution didn't mind what version of Windows you were using. When we moved to Defender, Defender had certain system prerequisites that had to be met. So we had to make sure that we're on a minimum version of Windows when we're utilizing Office, and Office has to be a particular version as well. It has more stringent system requirements that have to be met before you can implement it. It works natively together with other Microsoft solutions. Once you get more and more of those different components across the environment, then you start to get better visibility. So, rather than having lots of different solutions, you have fewer solutions and a single vendor solution. That way, you start getting into a position where you get better visibility and integration as well. The standardization is good. It's important. It's helping me with monitoring and learning. Updates and upgrades are quite smooth and seamless. Defender helps us automate routine tasks. Quite a lot of Microsoft is straightforward for us now. Previously, we didn't have enough resources and were unable to look at the alerts. Having this in place makes things a lot more straightforward for us. We have both the technology and the people in place now, alongside the process. We do see the benefits in that, and that's why we're continuing our adoption across the estate in terms of client and server as well. It's helping us avoid looking at multiple dashboards and centralized monitoring. We're not fully there yet. We're getting there. While we haven't witnessed time saving yet, once it's fully deployed, it will. By then, we'll have standardized processes across a single solution. We have saved money, however, as we continue to reduce non-Mircosft systems. Since we won't be using various competing technologies, we can save on licensing costs. We've likely so far saved 15%. While it's hard to estimate exactly how much, the solution has helped us decrease time to detection and time to respond.
RonnieYazdani - PeerSpot reviewer
User-friendly CLI and efficient dashboard streamline operations with robust security features
I find Palo Alto Networks VM-Series easy to deploy, and none of my customers have had significant complaints. My customers have high certifications provided by Palo Alto Networks. The friendly dashboard and the ability to easily command and use the CLI make Palo Alto Networks VM-Series a better product. It offers robust solutions, making it valuable to my customers.
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856,873 professionals have used our research since 2012.
 

Top Industries

By visitors reading reviews
Educational Organization
19%
Computer Software Company
12%
Government
7%
Financial Services Firm
7%
Computer Software Company
17%
Financial Services Firm
14%
Manufacturing Company
8%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
Which offers better endpoint security - Symantec or Microsoft Defender?
We use Symantec because we do not use MS Enterprise products, but in my opinion, Microsoft Defender is a superior solution. Microsoft Defender for Endpoint is a cloud-delivered endpoint security s...
How does Microsoft Defender for Endpoint compare with Crowdstrike Falcon?
The CrowdStrike solution delivers a lot of information about incidents. It has a very light sensor that will never push your machine hardware to "test", you don't have the usual "scan now" feature ...
Features comparison between Palo Alto and Fortinet firewalls
In the best tradition of these questions, Feature-wise both are quite similar, but each has things it's better at, it kind of depends what you value most. PA is good at app control, web filtering a...
How does Azure Firewall compare with Palo Alto Networks VM Series?
Both products are very stable and easily scalable. The setup of Azure Firewall is easy and very user-friendly and the overall cost is reasonable. Azure Firewall offers a solid threat awareness, can...
 

Also Known As

Microsoft Defender ATP, Microsoft Defender Advanced Threat Protection, MS Defender for Endpoint, Microsoft Defender Antivirus
No data available
 

Interactive Demo

Demo not available
 

Overview

 

Sample Customers

Petrofrac, Metro CSG, Christus Health
Warren Rogers Associates
Find out what your peers are saying about Microsoft Defender for Endpoint vs. Palo Alto Networks VM-Series and other solutions. Updated: June 2025.
856,873 professionals have used our research since 2012.