Yes. All well-known RPA products can interface with applications using exposed APIs. If not API, then via desktop automation for Web/Desktop applications. In some cases, you may have to use Java Access Bridge.
However, if it's a mainframe AS/400-based application, I have a…
Microsoft Power Automate - the most price-competitive RPA product with features at par with well known other RPA products.
The MS Power Automate has more than 500 connectors which become potent with Azure integration.
The most challenging automations supported are - Oracle…