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Cisco Secure Email Threat Defense vs Trend Micro InterScan Messaging Security comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
25th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Trend Micro InterScan Messa...
Ranking in Email Security
34th
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
3
Ranking in other categories
Secure Email Gateway (SEG) (14th)
 

Mindshare comparison

As of July 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.3%, down from 16.9% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Trend Micro InterScan Messaging Security is 0.7%, up from 0.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
Abdul  Waris - PeerSpot reviewer
Deploy features like DLP and BEC for enhanced security
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement With Trend Micro email security gateway, we can deploy features like DLP and BEC. It includes Office 365 protection and sandboxing. This provides…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"It has significantly decreased my time to detection and response."
"My experience deploying Microsoft Defender for Office 365 was seamless."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"Scalability-wise, I do not think there are any issues so far."
"Microsoft Defender for Office 365's most valuable features are safe attachments and safe links."
"At the moment we are satisfied with this product. It's a stable, scalable, and resilient solution for us."
"The basic features are okay and I'm satisfied with the Defender."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The product offers protection, email security, anti-spam, and antivirus."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"It has an efficient email filtering feature."
"The solution is stable."
"Secure Email Threat Defense's scalability is good."
"It's very easy to deploy and configure."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"With Trend Micro email security gateway, we can deploy features like DLP and BEC."
"The technical support services are excellent."
"With Trend Micro email security gateway, we can deploy features like DLP and BEC."
"The solution provides protection with its Email Track Records and Machine Manual features."
 

Cons

"The changes to customer service, specifically the new model for support agreements, are not favorable."
"We need a separate license and we don't know how to get the license that is required."
"There is a different console for different things; I just want one consolidated console."
"In one of the reports I can get the exact place where a vulnerable file resides. But for that, I need to explicitly go into the device and check. If they could include that file part in the report, without my having to go to the device itself, that would help."
"In the areas of improvement for Microsoft Defender for Office 365, the console is the biggest challenge for me."
"I am generally satisfied with how it currently is. If I could improve anything, I would reduce the cost."
"Microsoft Defender for Office 365 should improve the troubleshooting tools. It's unclear whether the device is blocked at the firewall level or at the device itself. The granularity needed for troubleshooting is currently lacking. From my perspective, Microsoft should address this issue to benefit many users who likely share the same sentiment."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"We encounter issues while searching for missing emails."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"The behavioral analysis capability of Cisco Secure Email Threat Defense is not particularly helpful for identifying new, evolving threats within my company, as it keeps flagging legitimate emails as malicious."
"The solution's pricing could be improved."
"There is room for improvement in content filtration, expressions, file sharing, and policy configuration."
"There is room for improvement in content filtration, expressions, file sharing, and policy configuration."
"The product's pricing could be more flexible."
 

Pricing and Cost Advice

"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"The product is expensive."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"I was working in the government and it was too expensive for us to use our Microsoft products."
"While Microsoft Defender for Office 365 necessitates pricier E3 or E5 subscriptions, the extensive functionality offered by these licenses across various Microsoft products justifies the investment."
"For large enterprise organizations, they can definitely afford it, but for small and medium organizations, they might struggle to cover the expenses."
"I know that the product is incredibly expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"Trend Micro is an expensive solution."
"I rate Trend Micro InterScan Messaging Security’s pricing a seven out of ten."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
29%
Healthcare Company
7%
Government
6%
Manufacturing Company
6%
Financial Services Firm
10%
Manufacturing Company
10%
Computer Software Company
9%
Performing Arts
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
No data available
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The integration capability with other threat intelligence platforms is not optimal, as I have experienced difficulty ...
What is your experience regarding pricing and costs for Trend Micro InterScan Messaging Security?
The price is a bit high because the market is highly competitive. Multiple platforms are available, so we have to cho...
What needs improvement with Trend Micro InterScan Messaging Security?
There is room for improvement in content filtration, expressions, file sharing, and policy configuration. We could de...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
InterScan Messaging Security
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Copa Airlines, Air21, BookMyShow, Bulgarian American Credit Bank, Canadian Museum of History, CIBIL, Community National Bank, Dar Al-Handasah
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Trend Micro InterScan Messaging Security and other solutions. Updated: June 2025.
860,592 professionals have used our research since 2012.