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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
49
Ranking in other categories
Advanced Threat Protection (ATP) (1st), Microsoft Security Suite (11th)
Cisco Secure Email Threat D...
Ranking in Email Security
20th
Average Rating
8.0
Reviews Sentiment
7.0
Number of Reviews
13
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
4th
Average Rating
8.4
Reviews Sentiment
6.9
Number of Reviews
38
Ranking in other categories
Anti-Malware Tools (8th)
 

Mindshare comparison

As of May 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.9%, down from 18.3% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, down from 1.2% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 6.7%, down from 9.1% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Mike Bulyk - PeerSpot reviewer
Can quickly identify, track, tag, and categorize internal emails. Reporting accessibly via the main dashboard would be a great addition.
If Cisco could continue to develop integrations, whether it's internal tooling, Threat Grid, or AMP reporting which could be accessible via a single web page, that would be helpful. This would essentially add additional context on messages as well as files or links being detected. Potentially adding additional context on why certain messages are tagged as spam or malware. In our case, malware hasn't been detected yet, but spam certainly has been. Knowing what engines or which components of the message make it identifiable as spam, that could be useful. Additional context and reporting accessibly via the main dashboard would be great. There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting.
Nur Mohammad - PeerSpot reviewer
An effective email security solution that provides DLP, Safe Attachment, and Safe Links
If you want extensive email security, you need to purchase a Plan 2 license. Plan 1 and Plan 2 are the two plans for Microsoft Exchange Online Protection. Some customers hesitate to purchase this product because it adds some costs to them, which is necessary for them. It would be helpful for customers if Plan 1 features were included with EOP. However, they still need to purchase Plan 2 for advanced security features. One of our clients recently requested to compare Zimbra's features with Microsoft Exchange Online Protection. Zimbra is open source, while Microsoft Exchange Online Protection is not. When I compare both the products, many free features are available in Zimbra because it is open-source software. It makes no sense to request Microsoft Exchange Online Protection add all the features people get on open-source software like Zimbra. Hence, I would say whatever features Microsoft Exchange Online Protection has are enough. Microsoft has a dedicated research team that should research and add new techniques like phishing and spamming solutions to the product.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I like its investigation capabilities, as that is what is most important to me. It is fairly simple with a user-friendly interface."
"The good part is that you don't have to configure it, which is very convenient."
"The technical support is good and quick to resolve issues."
"It gives us visibility into threats and, for endpoints, it helps us to prioritize threats. We used to have a lack of visibility, but now our time to detect and respond has decreased."
"Scalability-wise, I do not think there are any issues so far."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"Microsoft Defender for Office 365's most valuable feature is its performance."
"There are several features that I consider valuable."
"It's very easy to deploy and configure."
"It has an efficient email filtering feature."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"The features and functionalities are much better than Microsoft's in-built Defender plan."
"Secure Email Threat Defense's scalability is good."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"The ability to see east-west traffic is its most valuable feature. Traditionally, email defense focuses on north-south, inbound-outbound, egress-ingress traffic. With Cisco Secure Email Cloud Mailbox, it's able to quickly identify, track, tag, and categorize emails that are internal. That can typically give us visibility into if there's an internal compromised account (for example). Someone can then use that internal compromised account to email additional accounts with either malicious software or links, but internal within that Office tenant. Effectively, that email message never leaves the tenant. Any of the mail gateways really do not have any method or way of seeing this traffic since it's not leaving the environment."
"This solution is easy to use."
"You can use the product to create special accounts."
"The solution's stability is very, very good. I didn't face any problems in the last year."
"We use the solution to receive emails. We do not use the calendar function as our clients are slow adaptors to the latest features."
"With Microsoft Exchange Online Protection, if malware is attached to a mailer, it's very easy to go into the incident alert and find out what's happening with that identity and the mail."
"The initial setup is just a standard process."
"It provides security to both on-premises and Azure infrastructures."
"What I like most about Microsoft Exchange Online Protection is its integration with Windows, so we have one central view for all alerts and incidents."
"The most valuable feature of Microsoft Exchange Online Protection is the accidental release of information protection capabilities. Additionally, the solution is easy to use."
 

Cons

"In some situations, it has not been able to pick impersonated emails having no attachments. Technical support definitely has a scope for improvement."
"There's room for improvement regarding the time frame for retrieving emails."
"In one of the reports I can get the exact place where a vulnerable file resides. But for that, I need to explicitly go into the device and check. If they could include that file part in the report, without my having to go to the device itself, that would help."
"The GUI is sometimes slow to fetch the device report and could be improved."
"One area for improvement is integration. For example, when it comes to external SaaS platforms, we were not able to get a lot of information on integrations with such apps for security and authentication."
"The only thing they should improve is the licensing model. They should stop changing it. A year ago, the five features I mentioned were included in one product. Now, three of them are bundled into one product, and you have to pay extra for the other two. I don't mind paying extra, but I don't want them to change it every year or every six months. I need to know what I'm looking at and not worry about it next year."
"The visibility for the weaknesses in the system and unauthorized access can be improved."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"The tool gives false positives and it needs to be more accurate. I would like to see AI as a new feature."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"We encounter issues while searching for missing emails."
"The physical appliance has been discontinued, although the platform still exists."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The solution is a bit expensive."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"This solution could be improved by integration with Sandbox."
"The reporting needs a little bit of improvement."
"They should specify the difference between Defender for Office 365 and Exchange Online Protection."
"Some of the searchability when looking for specifics in Exchange logs is tedious."
"The product's end-of-life cycle could be extended."
"When the product is being updated, it changes some of the setups. The support team is also not good."
"The security features could be better."
"Not all settings can be configured automatically and most still require manual configuration. However, there is an automation tool available that can be used to input all the configurations either as a script or a tool it would be helpful."
"When you're using a Microsoft product solution, you can scale it, but if you're not, there are limitations."
 

Pricing and Cost Advice

"Defender for 365 comes in various plans and licenses, along with other Microsoft security solutions. Purchasing this kind of package or security bundle gives good value for money, and that's what I recommend."
"For licensing, it's usually a yearly package for customers who are subscribed to Office 365, but they can also pay on a monthly basis."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"The license is expensive because the cost is based on the number of users."
"It's a user-base subscription."
"The pricing is normal. Considering its popularity, it's not overpriced."
"It is expensive compared to other vendors."
"The feedback from vendors and customer is that it is expensive."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"The solution's pricing is subscription-based rather than a yearly licensing cost. Pricing is based on the size of the environment and company and can be expensive."
"The pricing of the solution is reasonable."
"The solution is priced high and could be less expensive compared to other solutions."
"The product's pricing is competitive for the US market."
"It's a high price."
"The solution falls on the higher or more expensive side of the spectrum."
"Regarding the price, it's comparable to other service providers. We've also looked at Check Point's offerings, and the pricing doesn't seem to be an issue."
"The pricing for the solution depends on what you are trying to achieve with the use of the product, but I know that it is not a cheaply priced product. Yearly payments have to be made towards the licensing fees of the solution."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Government
6%
Computer Software Company
36%
Healthcare Company
5%
Manufacturing Company
5%
Comms Service Provider
5%
Computer Software Company
15%
Government
9%
Financial Services Firm
9%
Manufacturing Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Money-wise, it is a part of the Office 365 ( /products/office-365-reviews ) suite, making it slightly more expensive ...
What needs improvement with Microsoft Defender for Office 365?
The main area for improvement is simplifying the implementation and rollout process. There are many conditions to be ...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The physical appliance has been discontinued, although the platform still exists. Improvements here and there could b...
What do you like most about Microsoft Exchange Online Protection?
The initial setup was easy. The configuration process is very straightforward.
What needs improvement with Microsoft Exchange Online Protection?
I would like to improve the setting of rules in Microsoft Exchange Online Protection (EOP) as it is currently working...
What is your primary use case for Microsoft Exchange Online Protection?
I am using Microsoft Exchange Online Protection (EOP) ( /products/microsoft-exchange-online-protection-eop-reviews ) ...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: April 2025.
849,686 professionals have used our research since 2012.