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Cisco Secure Email Threat Defense vs Microsoft Exchange Online Protection (EOP) comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Dec 3, 2024

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cisco Secure Email Threat D...
Ranking in Email Security
23rd
Average Rating
8.0
Reviews Sentiment
6.7
Number of Reviews
16
Ranking in other categories
No ranking in other categories
Microsoft Exchange Online P...
Ranking in Email Security
9th
Average Rating
8.2
Reviews Sentiment
6.6
Number of Reviews
42
Ranking in other categories
Anti-Malware Tools (14th)
 

Mindshare comparison

As of September 2026, in the Email Security category, the mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.0% compared to the previous year. The mindshare of Microsoft Exchange Online Protection (EOP) is 2.9%, down from 5.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security Mindshare Distribution
ProductMindshare (%)
Microsoft Exchange Online Protection (EOP)2.9%
Cisco Secure Email Threat Defense1.1%
Other96.0%
Email Security
 

Featured Reviews

GC
Senior Cybersecurity Engineer at a financial services firm with 11-50 employees
Provides robust email security features but requires improved modernization and complexity management
Modernization is an area that could be improved for Cisco Secure Email Threat Defense, as some features have lagged behind newer competitors, potentially offering more advanced analysis capabilities. The initial setup is not straightforward and requires expertise and time to master configurations such as spoofing and DLP. More control over backend functionalities and simplifying rule management could enhance user experience. The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration. Furthermore, the pricing might deter new users who could opt for alternative, more cost-effective solutions.
NancyHartman - PeerSpot reviewer
Business Process Manager/ Educational Technologist at a educational organization with 1,001-5,000 employees
Layered email security has protected sensitive research and still flags phishing in real time
The valuable features of Microsoft Exchange Online Protection (EOP) include providing an additional layer of protection, as it builds on the basic Exchange level of security that allows us to get our work done. Another feature I appreciate is the ability to question things, as our Exchange server allows us to identify in real-time if an email is a phishing email or spam email. It really helps us identify risks, especially through our external exchanges via email or through our cloud-based platforms. Our Exchange system blocks any embedded AI from all our applications and products, so we cannot use embedded AI in our daily work from our official laptops because we have secure information. The system is quite locked down.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"This solution is easy to use."
"Overall, it's certainly a very good idea to integrate another layer on top of Microsoft Advanced Threat Protection."
"I highly recommend it as one of the best choices."
"The product offers protection, email security, anti-spam, and antivirus."
"It has an efficient email filtering feature."
"On ease of use, it rates very high."
"It has a really nice web-based administration console."
"It is an easy solution."
"I like the product's ZAP feature."
"Microsoft Exchange Online Protection (EOP) is the best email solution with more features and robust security, making it ideal for corporate use."
"Online Protection's most valuable feature is its admin interface."
"The solution's stability is very, very good. I didn't face any problems in the last year."
"What I like most about Microsoft Exchange Online Protection is its integration with Windows, so we have one central view for all alerts and incidents."
"It's all running in the backend, so it doesn't affect the app functionality."
 

Cons

"The product's complexity at times results in redundant rule sets that are difficult to untangle, highlighting the need for streamlined management systems and a more user-centric approach to system configuration."
"This solution could be improved by integration with Sandbox."
"The solution is a bit expensive. It could be cheaper."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"We encounter issues while searching for missing emails."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"There is still room for improvement in terms of integrations with other Cisco tools and non-Cisco tools. There is also some room for improvement needed in terms of the reporting."
"We would like the solution to have more in-built intelligence in the way that it reviews potential security risks, rather than our team constantly having to update the policies."
"The solution can be complex at times. It would be nice to have the on-server version. It needs to improve the stability as well."
"Not all settings can be configured automatically and most still require manual configuration. However, there is an automation tool available that can be used to input all the configurations either as a script or a tool it would be helpful."
"The biggest issue that I experience is that Microsoft keeps moving things around, and it's very inconsistent as to where you find the information when you're trying to work on different pieces."
"They should specify the difference between Defender for Office 365 and Exchange Online Protection."
"The security compliance features need to be improved. Sometimes, a client's mailbox becomes full because of retained information and not because of mail. I would like to see improvement in block rules as well."
"Having orchestration features added to Microsoft Exchange Online Protection, particularly automation and remediation, would be quite useful."
"It doesn't protect against everything. We do need protection for, for example, endpoints."
 

Pricing and Cost Advice

"It is expensive compared to other vendors."
"The solution’s pricing is manageable."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The feedback from vendors and customer is that it is expensive."
"It's a high price."
"Apart from the license fee for the solution, there are no additional costs."
"The solution is priced high and could be less expensive compared to other solutions."
"The solution should reduce the cost."
"The solution falls on the higher or more expensive side of the spectrum."
"Microsoft Exchange Online Protection is a good solution at an affordable price. It is a good investment."
"The solution is expensive but is backed by Microsoft's reputation."
"The solution's pricing is subscription-based rather than a yearly licensing cost. Pricing is based on the size of the environment and company and can be expensive."
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Top Industries

By visitors reading reviews
Marketing Services Firm
11%
Outsourcing Company
9%
Comms Service Provider
8%
Healthcare Company
8%
Financial Services Firm
11%
Manufacturing Company
9%
Comms Service Provider
9%
Computer Software Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise6
Large Enterprise7
By reviewers
Company SizeCount
Small Business23
Midsize Enterprise6
Large Enterprise13
 

Questions from the Community

What is your experience regarding pricing and costs for Secure Email Threat Defense?
Comparatively with other products, the pricing of Cisco Secure Email Threat Defense is normal. As a technical guide, I am not very aware of the pricing details.
What needs improvement with Secure Email Threat Defense?
We have deployed Cisco Secure Email Threat Defense in two customer environments. It is still in development as a new product. Some customer requirements, such as sending logs to a Syslog server, ar...
What is your primary use case for Secure Email Threat Defense?
We are working with Cloud Mail Gateway and on-premise mail gateways. We have worked with Cisco Secure Email Threat Defense.
What needs improvement with Microsoft Exchange Online Protection?
From an end-user point of view, I am quite happy with Microsoft Exchange Online Protection (EOP) because my favorite feature is the ease with which I can identify if an email is a phishing email or...
What is your primary use case for Microsoft Exchange Online Protection?
Microsoft Exchange Online Protection (EOP) serves as the main use case for my company because, as a research company, we require a very high level of security. We use multiple authentication method...
What advice do you have for others considering Microsoft Exchange Online Protection?
My experience with Microsoft Exchange Online Protection (EOP) is from an end-user perspective, and I do not have admin management experience. I am not familiar with the Advanced Threat Protection f...
 

Also Known As

Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
Microsoft EOP, MS Exchange Online Protection
 

Overview

 

Sample Customers

Luiss University, Lone Star College, T-Systems, Magyar Telekom
Information Not Available
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Microsoft Exchange Online Protection (EOP) and other solutions. Updated: September 2026.
914,322 professionals have used our research since 2012.