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Cisco Secure Email Threat Defense vs Darktrace comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Jun 15, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Sponsored
Ranking in Email Security
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
52
Ranking in other categories
Email Archiving (1st), Advanced Threat Protection (ATP) (2nd), Microsoft Security Suite (10th), Secure Email Gateway (SEG) (1st)
Cisco Secure Email Threat D...
Ranking in Email Security
20th
Average Rating
8.0
Reviews Sentiment
7.1
Number of Reviews
14
Ranking in other categories
No ranking in other categories
Darktrace
Ranking in Email Security
10th
Average Rating
8.2
Reviews Sentiment
7.2
Number of Reviews
82
Ranking in other categories
Intrusion Detection and Prevention Software (IDPS) (1st), Network Traffic Analysis (NTA) (1st), Network Detection and Response (NDR) (1st), Extended Detection and Response (XDR) (6th), AI-Powered Chatbots (3rd), Cloud Security Posture Management (CSPM) (15th), Cloud-Native Application Protection Platforms (CNAPP) (11th), Attack Surface Management (ASM) (4th), AI-Powered Cybersecurity Platforms (2nd)
 

Mindshare comparison

As of June 2025, in the Email Security category, the mindshare of Microsoft Defender for Office 365 is 12.6%, down from 17.6% compared to the previous year. The mindshare of Cisco Secure Email Threat Defense is 1.1%, up from 1.1% compared to the previous year. The mindshare of Darktrace is 3.0%, up from 1.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Email Security
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
Enrique-Diaz Jolly - PeerSpot reviewer
Provides comprehensive threat protection with suggestions for modernizing controls
I use the email gateway as the core of the email exchange between the Internet and our domain. The email gateway serves as the email exchanger The product offers protection, email security, anti-spam, and antivirus. It includes threat intelligence with advanced malware protection and many…
Malebo Lethoba Group - PeerSpot reviewer
Have found the AI analyst and detection functions highly valuable for network operations while managing complexity in initial setup
The functions I find most valuable in Darktrace ( /products/darktrace-reviews ) are the AI analyst as well as the detection.The autonomous response capabilities of Darktrace are not crucial for me because it doesn't work in a network where there are no core switches. In a modern network, the autonomous response doesn't work, especially when sitting in a shared data center.If I'm running a traditional network where I am not in a shared data center with a layer two dedicated for my resources, then it can work for me. However, if I am in a data center where I don't have layer two, it becomes an issue because the autonomous response is reliant on sending spoofed TCP resets to my core switch to block traffic, which is a major issue.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The most valuable feature of Microsoft Defender for Office 365 is the ease of use."
"Microsoft Defender for Office 365's most valuable features are safe attachments and safe links."
"Defender enables us to secure all 365-related activity from a single place. It gives us visibility into everything happening in Outlook, protecting us against phishing and other email-based threats. Defender helps us detect any suspicious behaviors."
"The two main features that prove most beneficial for us are URL scanning and attachment scanning."
"My experience with customer support and technical support for Microsoft Defender for Office 365 has been excellent."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"The benefit that stands out to me is the ability for multiple individuals to collaborate simultaneously within the same document. Additionally, there is the option to save the document directly in the integrated OneDrive or SharePoint."
"The most valuable feature is protection against malicious links, fishing, and impersonation. You can train people to be aware of these threats, but they're not always careful. When they're using their phones between meetings, they click on a link, and it's game over."
"Cisco has a threat mechanism called cloud-based Talos, where all the threats are inbuilt."
"Cisco Secure Email Cloud Mailbox can handle a complete portfolio, which is required to protect any kind of attack coming from emails. However, it does not have advanced phishing, but it is available through Cisco. If you compare Cisco Secure Email Cloud Mailbox with the competition, in the competition you have to have one or two solutions together to address the customer's requirement, whereas Cisco Secure Email Cloud Mailbox is addressing everything, such as web domain and email protection. If there is any kind of challenge it will come across through email."
"This solution is easy to use."
"Regarding stability, Cisco Secure Email Threat Defense is very stable."
"It's very easy to deploy and configure."
"The solution is stable."
"I would say it's very comprehensive, with multiple antivirus OEMs, virus encrypt features, encryption, and more."
"The product offers protection, email security, anti-spam, and antivirus."
"The platform has many modules, and each module examines a different situation in the behavior."
"A very useful feature in Darktrace for real-time threat analysis is the packet inspection that analyzes the packet traffic in real time."
"I can rate Darktrace's technical support as one of the best products in the world."
"Darktrace is valuable since it offers full packet capture and detailed metadata."
"What I like about Darktrace, is that you can quickly identify threats."
"Its AI technology supports cybersecurity by learning my environment and accurately responding to threats."
"Provides great network protection."
"It is very easy to work with Darktrace once you know how it works and the type of permissions that you need to get related to the security over a network. The interface is awesome. I'm sure that you have seen Ironman, and you know Jarvis, the computer of Tony Stark. The interface of Darktrace is very similar, and you can see in 3D, like a hologram, the whole network, traffic, and all the traces inside the network. The interface is awesome, and it provides a lot of information. At least for us, it is very easy to handle this interface, get the reports, and do the interpretation of those reports. Darktrace also provides mobile monitoring. With an app on your mobile phone, you can view the information live, which is very useful for area directors and field engineers. Darktrace can be also correlated with any type of big data solution, such as Splunk."
 

Cons

"Microsoft security solutions work as expected. They are constantly updating the solutions to make them better. At the same time, the changes can impact a customer's environment, and we need to adjust settings. Sometimes we aren't aware of the changes, and nothing is pushed from the backend automatically."
"The visibility into threats is not up to the mark, as I do not have control. I rate my experience with Microsoft Defender for Office 365 as six out of ten due to troubleshooting and pricing concerns."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"Sometimes, phishing emails manage to pass through the filter, so the system needs to enhance its phishing email detection capabilities."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"We need to be able to whitelist data at the backend."
"Configuration at the mid-level could be improved for the support team."
"Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published."
"From a technical point of view, Cisco is far behind in terms of cybersecurity, and it has to improve very much."
"The pricing could always be better."
"Customers will benefit greatly from monthly billing because the majority of customers today use the cloud, be it Office 365, or Google Cloud."
"The solution is a bit expensive."
"This solution could be improved by integration with Sandbox."
"Cisco's multiple product lines and verticals made this just one of their many verticals, and we could see a shift in focus."
"Cisco Secure Email Cloud Mailbox can improve by adding advanced phishing, then the solution would become the best in the market. However, this could increase the price even more. Additionally, if CES with domain protection could be added it would be an even better solution."
"The search area has room for improvement. When you go to the next page, it remains at the bottom of the current page that you're on. Also, under the reports section, it allows you to see any "convictions," but if you want to search for those convictions you have to remember when they all came in and go back and edit the search accordingly. You cannot click on the list of convictions to actually see if you had a spike at a certain time."
"The pricing is a bit high for the region."
"A reporting portal could be a great addition to help customize reports."
"It should be easier to access the Darktrace portal and its documentation. Only the customer can access their portal and support. It could be cheaper."
"The solution's user interface and stability could be improved."
"There aren't so many third-party vendor platforms natively integrated with the platform."
"In the next version, I'd like to see penetration testing."
"In a shared environment, it doesn't work, and there are still some integration issues."
"This product needs more in terms of prevention. The detection capabilities work well but once a threat has been detected, Darktrace should work to prevent it from doing anything malicious."
 

Pricing and Cost Advice

"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"Microsoft Defender is expensive. I typically recommend it only if clients have the budget. Otherwise, I would suggest an alternative."
"The product is expensive."
"I know that the product is incredibly expensive."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"The solution could be better by simplifying the business model of their licensing. It was hard to figure out how to get the licensing done for the environment, initially."
"The pricing has become expensive."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Cisco Secure Email Cloud Mailbox does not have any competition with Sophos, Trend Micro, or other vendors of the world. However, there is a pricing premium for the solution. One has to look at it from that angle that while they are buying Cisco, there will be a premium, and Cisco justifies that premium value. That's why they're charging a high price."
"The solution’s pricing is manageable."
"The feedback from vendors and customer is that it is expensive."
"It is expensive compared to other vendors."
"If you consider the features and the cost of market leaders, we are satisfied with the pricing."
"The pricing is reasonable."
"When it comes to large installations, it can be expensive, but for small accounts it's fine."
"The cost is moderate."
"The pricing is expensive. It costs over $100,000 a year."
"The pricing is quite high, estimated at around $350,000 per year."
"The price of Darktrace is high and could be reduced. We pay approximately $30,000 to $54,000 annually."
"In the ballpark, we're talking about $30K, $50K, and up. It can even be as much as $50K or $100K."
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Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
9%
Manufacturing Company
8%
Government
6%
Computer Software Company
30%
Government
7%
Healthcare Company
7%
Financial Services Firm
5%
Computer Software Company
14%
Manufacturing Company
8%
Financial Services Firm
8%
Government
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of variou...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Microsoft is quite affordable with a lot of features available for any size organization.
What needs improvement with Microsoft Defender for Office 365?
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS recor...
What do you like most about Secure Email Threat Defense?
Secure Email Threat Defense's scalability is good.
What is your experience regarding pricing and costs for Secure Email Threat Defense?
Cisco's closest competition is Proofpoint. Both are in the same range in terms of pricing. Pricing is on the higher s...
What needs improvement with Secure Email Threat Defense?
The physical appliance has been discontinued, although the platform still exists. Improvements here and there could b...
How does Crowdstrike Falcon compare with Darktrace?
Both of these products perform similarly and have many outstanding attributes. CrowdStrike Falcon offers an amazing u...
Which is better - SentinelOne or Darktrace?
Which solution is better depends on which is more suitable specifically for your company. Darktrace, for example, is ...
What do you like most about Darktrace?
A very useful feature in Darktrace for real-time threat analysis is the packet inspection that analyzes the packet tr...
 

Also Known As

MS Defender for Office 365
Cisco Secure Email Cloud Mailbox, Cisco CMD, Cisco Cloud Mailbox Defense
No data available
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Luiss University, Lone Star College, T-Systems, Magyar Telekom
Irwin Mitchell, Open Energi, Wellcome Trust, FirstGroup plc, Virgin Trains, Drax, QUI! Group, DNK, CreaCard, Macrosynergy, Sisley, William Hill plc, Toyota Canada, Royal British Legion, Vitol, Allianz, KKR, AIRBUS, dpd, Billabong, Mclaren Group.
Find out what your peers are saying about Cisco Secure Email Threat Defense vs. Darktrace and other solutions. Updated: June 2025.
856,873 professionals have used our research since 2012.