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Microsoft Defender Vulnerability Management vs Prisma Cloud by Palo Alto Networks comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Jan 11, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
4.9
Determining ROI for Microsoft Defender Vulnerability Management is challenging due to service bundling and mixed-use of other products.
Sentiment score
6.9
Prisma Cloud boosts productivity, enhances security, and delivers high ROI by automating processes and reducing manual testing needs.
Organizations typically do not rely solely on Microsoft products to avoid putting all eggs in one basket, which presents a challenge for maximizing ROI.
Cloud Security Engineer at a computer software company with 51-200 employees
As a Microsoft partner, we receive significant discounts, making the solution affordable for us.
COO at Floating-Dot Technology LTD
It eliminates the need for additional hardware, making it a financially and technically sound investment.
Partner at Quasys
Reputation and data security are the two most important things to a financial institution.
Works at a comms service provider with 1-10 employees
We may have prevented a security breach with remediation of the findings.
Security Solutions Architect - Cloud Security Consultant at a consultancy with 10,001+ employees
 

Customer Service

Sentiment score
6.6
Microsoft Defender's support is praised for expertise but criticized for communication delays and varying service quality.
Sentiment score
7.1
Palo Alto Networks' technical support is praised for responsiveness, though regional inconsistencies and response time improvements are noted.
They are sometimes responsive, however, often issues cannot be reproduced on their end, making it challenging.
Security Specialist at Prudential Systems Japan
The support we receive from Microsoft is declining, and for example, after taking advanced support, we have not received satisfactory answers.
Microsoft Solutions Manager at Self-Employed
They are familiar with Microsoft products but are not direct Microsoft staff, which is an area needing improvement.
Cloud Security Engineer at a computer software company with 51-200 employees
They can respond with technical documentation or pass on the case to the next level because it requires the development of a new feature or changing a feature due to a bug.
Technical Lead at a consultancy with 11-50 employees
Anywhere we raise a tech case, they revert back within an hour.
Cloud Security Engineer at a tech vendor with 201-500 employees
I would give them 10 out of 10.
Sector Manager at a comms service provider with 51-200 employees
 

Scalability Issues

Sentiment score
7.6
Microsoft Defender excels in scalability and integration but faces documentation and on-premise infrastructure challenges across industries.
Sentiment score
7.6
Prisma Cloud offers scalable, flexible multi-cloud solutions with easy deployment, strong automation, API support, and high scalability ratings.
The integration is straightforward for those who understand it, though documentation needs improvement.
Cloud Security Engineer at a computer software company with 51-200 employees
It is scalable; I evaluated the product and decided to use Defender on over 700 of our company servers.
Security Specialist at Prudential Systems Japan
Scalability-wise, I rate the solution a nine out of ten.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
We haven't had any issues scaling the solution.
Senior Cloud Security Engineer at impelsys
There aren't any limits to Prisma Cloud's scalability.
Senior Security Consultant at helpag
 

Stability Issues

Sentiment score
6.6
Microsoft Defender Vulnerability Management is highly stable and reliable, with minimal downtime, despite minor resource-related and compatibility issues.
Sentiment score
7.9
Prisma Cloud is praised for its high stability, reliability, and effective troubleshooting, with minor well-managed issues.
There are compatibility issues occasionally arising with false positives when other security tools are not whitelisted in Microsoft Defender.
information Security and IT Manager at Discover Dollar Technologies Pvt Ltd.
It is very resource-intensive, consuming a lot of memory and CPU.
Security Specialist at Prudential Systems Japan
If Microsoft experiences downtime, this solution goes down as it is a SaaS-based solution where we have no control.
Cloud Security Engineer at a computer software company with 51-200 employees
I would rate it a ten out of ten for stability.
Cloud Security Engineer (Team lead) at a tech services company with 201-500 employees
Most of the time, when the client requires data, it is not available.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
The cloud environment is dynamic, so the tool must be dynamic.
Cloud Security Delivery Associate Manager at Accenture
 

Room For Improvement

Microsoft Defender needs better false positive reduction, integration, cost management, risk scoring, and documentation for small enterprises.
Prisma Cloud struggles with integration, UI, automation, cloud coverage, reporting, support, and pricing, hindering broader adoption and usability.
This scoring should be for specific industries as well. If I belong to the healthcare industry using Microsoft Defender Vulnerability Management, it should provide me with a risk score and show how I fare against the risk score of my industry.
DGM. Technical Security at a tech services company with 10,001+ employees
A vulnerability I patch within 15 minutes takes 24 additional hours for an update.
information Security and IT Manager at Discover Dollar Technologies Pvt Ltd.
The product is not stable; it often uses excessive memory and CPU, which makes it slow.
Security Specialist at Prudential Systems Japan
Prisma Cloud is an excellent tool.
Technical Engineer at a tech services company with 1,001-5,000 employees
We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts.
Cyber Security Architect at a comms service provider with 10,001+ employees
Even though documentation was available, it took a while for a new person to understand what integration meant, what will be achieved after the integration, or how the integration needed to be done on the Azure or AWS side.
Technical Architect at a tech services company with 1,001-5,000 employees
 

Setup Cost

Microsoft Defender Vulnerability Management provides economical tiered pricing with P1 and P2 options, often included in existing bundles.
Prisma Cloud's complex pricing is offset by comprehensive features, offering cost efficiency with strategic planning despite hidden costs.
Overall, every organization wishes for cheaper options, but we look at the security side as well, so we are good for now.
Senior Cloud Security Consultant at MetLife
For non-partners, however, the cost could be seen as higher, between seven to ten.
COO at Floating-Dot Technology LTD
The pricing is reasonable, and it's included in the whole Microsoft E5 bundle, so it's all-inclusive.
Corporate Planner at MISC Berhad
The cost was not on the higher side.
Technical Architect at a tech services company with 1,001-5,000 employees
If you are using a single tool like Prisma Cloud, with a single license, you can monitor all environments, such as Google Cloud, Azure, AWS, and Oracle Cloud.
Cloud Security Delivery Associate Manager at Accenture
It is an expensive tool.
CTO at Cyberlinx
 

Valuable Features

Microsoft Defender excels in compliance, real-time assessments, risk prioritization, integration, asset discovery, and continuous monitoring for enhanced security management.
Prisma Cloud offers advanced cloud security with continuous monitoring, automation, and centralized management, enhancing operational efficiency across industries.
The main advantage of Microsoft Defender Vulnerability Management is that it can locate and prevent most threats even when the endpoints are not connected to the corporate network, as long as the internet is available.
DGM. Technical Security at a tech services company with 10,001+ employees
The feature for customizing to region-specific and domain-specific requirements in healthcare is particularly beneficial.
Cloud Security Engineer at a computer software company with 51-200 employees
The most valuable aspect is the kind of assessment results I get, and the recommendations provided in Microsoft products really help in taking care of the resources.
Senior Cloud Security Consultant at MetLife
It provides a single pane of glass.
enterprise architect at a tech services company with 1-10 employees
If I want to check how many of my S3s have encryption, I can write a Lambda function in Prisma Cloud and get that report.
Senior IT infrastructure consultant at a tech services company with 51-200 employees
Overall, the most valuable features for us in Prisma Cloud are those that provide visibility, ensure compliance with regulations, and help us align our on-premises servers and cloud environments with mandated security standards.
Architect at a tech vendor with 10,001+ employees
 

Categories and Ranking

Microsoft Defender Vulnerab...
Average Rating
8.2
Reviews Sentiment
6.5
Number of Reviews
17
Ranking in other categories
Vulnerability Management (12th), Advanced Threat Protection (ATP) (17th), Microsoft Security Suite (19th), Risk-Based Vulnerability Management (6th)
Prisma Cloud by Palo Alto N...
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
114
Ranking in other categories
Web Application Firewall (WAF) (9th), Container Security (2nd), Cloud Security Posture Management (CSPM) (2nd), Cloud-Native Application Protection Platforms (CNAPP) (2nd), Data Security Posture Management (DSPM) (2nd)
 

Mindshare comparison

While both are Security Software solutions, they serve different purposes. Microsoft Defender Vulnerability Management is designed for Vulnerability Management and holds a mindshare of 2.2%, down 3.2% compared to last year.
Prisma Cloud by Palo Alto Networks, on the other hand, focuses on Cloud-Native Application Protection Platforms (CNAPP), holds 12.4% mindshare, down 18.9% since last year.
Vulnerability Management Mindshare Distribution
ProductMindshare (%)
Microsoft Defender Vulnerability Management2.2%
Wiz6.4%
Tenable Nessus4.9%
Other86.5%
Vulnerability Management
Cloud-Native Application Protection Platforms (CNAPP) Mindshare Distribution
ProductMindshare (%)
Prisma Cloud by Palo Alto Networks12.4%
Wiz17.4%
Microsoft Defender for Cloud8.9%
Other61.300000000000004%
Cloud-Native Application Protection Platforms (CNAPP)
 

Featured Reviews

OB
Microsoft Solutions Manager at Self-Employed
Ensures strong threat and vulnerability management with continuous risk assessment
The major priority is identity, which is crucial; we have lots of companies in manufacturing, energy, or various sectors, and it varies from one to another. I assess Microsoft Defender Vulnerability Management as very effective in continuously assessing vulnerabilities without requiring scans. We use automatic investigation and remediation features, safe attachments, safe links, and real-time reports, which are also very effective. For Active Directory, Defender has threat intelligence, and we are using that. The risk-based prioritization within Vulnerability Management affects my ability to manage vulnerabilities, particularly in relation to the Zero Trust Model utilized by our customers. The end-users often do as they please in their systems.
reviewer2776578 - PeerSpot reviewer
Cyber Security Architect at a comms service provider with 10,001+ employees
Image scanning has supported consistent security practices during cloud deployment
On a scale of ten, we would say people are happy with Prisma Cloud by Palo Alto Networks for the part we use. People are okay with it. We probably would give an eight. We don't give ten because if we don't use the other parts of Prisma Cloud by Palo Alto Networks, it's because it was difficult to implement from an operational point of view. We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts. People have other tools and in the end, we don't use the full capabilities of a product that we pay for. It's partially related to the difficulty to integrate Prisma Cloud by Palo Alto Networks runtime in our company's support process. We don't use the real-time monitoring part of Prisma Cloud by Palo Alto Networks. We don't know about the automated remediation feature of Prisma Cloud by Palo Alto Networks.
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Top Industries

By visitors reading reviews
Financial Services Firm
11%
Computer Software Company
9%
Manufacturing Company
8%
Government
8%
Financial Services Firm
14%
Computer Software Company
10%
Manufacturing Company
9%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business9
Midsize Enterprise2
Large Enterprise6
By reviewers
Company SizeCount
Small Business37
Midsize Enterprise22
Large Enterprise56
 

Questions from the Community

What needs improvement with Microsoft Defender Vulnerability Management?
When I create rules, it gave me problems and I did not know where the problem was located. A small pop-up notification indicating how a rule should be configured would be helpful, rather than the p...
What is your primary use case for Microsoft Defender Vulnerability Management?
I do not use Microsoft Defender Vulnerability Management at work. However, I am currently not working, but I do use Microsoft Defender Vulnerability Management on my personal computer.
What is your primary use case for Prisma Cloud by Palo Alto Networks?
Prisma Cloud helps support DevSecOps methodologies, making those responsibilities easier to manage.
What Cloud-Native Application Protection Platform do you recommend?
We like Prisma Cloud by Palo Alto Networks, since it offers us incredible visibility into our entire cloud system. We are able to easily see where our container vulnerabilities lie and and where cl...
What do you think of Aqua Security vs Prisma Cloud?
Aqua Security is easy to use and very manageable. Its main focus is on Kubernetes and Docker. Security is a very valuable feature and their speed of integration is very good. The initial setup was ...
 

Also Known As

No data available
Prisma Public Cloud, RedLock Cloud 360, RedLock, Twistlock, Aporeto
 

Overview

 

Sample Customers

Information Not Available
Amgen, Genpact, Western Asset, Zipongo, Proofpoint, NerdWallet, Axfood, 21st Century Fox, Veeva Systems, Reinsurance Group of America
Find out what your peers are saying about Microsoft Defender Vulnerability Management vs. Prisma Cloud by Palo Alto Networks and other solutions. Updated: March 2025.
885,444 professionals have used our research since 2012.