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Microsoft Defender Vulnerability Management vs Prisma Cloud by Palo Alto Networks comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Jan 11, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
5.5
Qualys TotalCloud boosts efficiency, reduces manual effort, decreases risk, and offers significant cost savings with a notable ROI.
Sentiment score
4.4
Microsoft Defender's financial benefits are unclear, best within E5 suite, and difficult to assess against AWS for mixed solution users.
Sentiment score
6.9
Prisma Cloud boosts productivity, enhances security, and delivers high ROI by automating processes and reducing manual testing needs.
It has saved about 90% of our time.
Senior Consultant at a consultancy with 10,001+ employees
TotalCloud has generated overall savings of 30 to 40 percent across various departments.
Security Manager at a consultancy with 10,001+ employees
CallStream helps us integrate and automate tasks.
Senior Security Consultant at CyberNxt Solutions LLP
Organizations typically do not rely solely on Microsoft products to avoid putting all eggs in one basket, which presents a challenge for maximizing ROI.
Cloud Security Engineer at a computer software company with 51-200 employees
As a Microsoft partner, we receive significant discounts, making the solution affordable for us.
COO at Floating-Dot Technology LTD
It eliminates the need for additional hardware, making it a financially and technically sound investment.
Partner at Quasys
Reputation and data security are the two most important things to a financial institution.
Works at a comms service provider with 1-10 employees
We may have prevented a security breach with remediation of the findings.
Security Solutions Architect - Cloud Security Consultant at a consultancy with 10,001+ employees
 

Customer Service

Sentiment score
7.4
Qualys TotalCloud support is praised for efficiency and staff knowledge but criticized for delays and inconsistent quality.
Sentiment score
6.1
Microsoft Defender Vulnerability Management receives mixed reviews, highlighting expertise gaps and communication delays but valued for friendly assistance.
Sentiment score
7.1
Palo Alto Networks' technical support is praised for responsiveness, though regional inconsistencies and response time improvements are noted.
They are helpful, respond to my queries, and can answer any question.
Developer at a consultancy with 10,001+ employees
Qualys's tech support is highly responsive, providing multiple ways to interact with them.
Service Manager, Security Operations at CDA IT SOLUTIONS
Qualys' customer service provides quality answers, but the response time is long, even though it is within the SLA.
Works at a consultancy with 10,001+ employees
They are sometimes responsive, however, often issues cannot be reproduced on their end, making it challenging.
Security Specialist at Prudential Systems Japan
The support we receive from Microsoft is declining, and for example, after taking advanced support, we have not received satisfactory answers.
Microsoft Solutions Manager at Self-Employed
They are familiar with Microsoft products but are not direct Microsoft staff, which is an area needing improvement.
Cloud Security Engineer at a computer software company with 51-200 employees
They can respond with technical documentation or pass on the case to the next level because it requires the development of a new feature or changing a feature due to a bug.
Technical Lead at a consultancy with 11-50 employees
Anywhere we raise a tech case, they revert back within an hour.
Cloud Security Engineer at a tech vendor with 201-500 employees
I would give them 10 out of 10.
Sector Manager at a comms service provider with 51-200 employees
 

Scalability Issues

Sentiment score
7.8
Qualys TotalCloud excels in scalability, efficiently supporting diverse environments and business sizes, though it may require skilled management.
Sentiment score
7.0
Microsoft Defender Vulnerability Management is lauded for scalability and integration across environments, though some users seek improved documentation.
Sentiment score
7.6
Prisma Cloud offers scalable, flexible multi-cloud solutions with easy deployment, strong automation, API support, and high scalability ratings.
We started our organization about nine months back. We started with about 30 users, and we now have more than 100 users.
CIO at a venture capital & private equity firm with 11-50 employees
Our organization currently uses it to manage over 1200 web applications.
Analyst, Information Security at Infosys
It is absolutely scalable, and I would rate its scalability as nine out of ten.
retired at a consultancy with 10,001+ employees
The integration is straightforward for those who understand it, though documentation needs improvement.
Cloud Security Engineer at a computer software company with 51-200 employees
It is scalable; I evaluated the product and decided to use Defender on over 700 of our company servers.
Security Specialist at Prudential Systems Japan
Scalability-wise, I rate the solution a nine out of ten.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
We haven't had any issues scaling the solution.
Senior Cloud Security Engineer at impelsys
There aren't any limits to Prisma Cloud's scalability.
Senior Security Consultant at helpag
 

Stability Issues

Sentiment score
8.3
Qualys TotalCloud is highly stable with reliable support, 99.9% uptime, minimal bugs, and effective maintenance communication.
Sentiment score
6.7
Microsoft Defender Vulnerability Management is appreciated for stability and ease despite resource intensity and occasional compatibility issues.
Sentiment score
7.9
Prisma Cloud is praised for its high stability, reliability, and effective troubleshooting, with minor well-managed issues.
Overall, the support provided has been excellent.
Analyst, Information Security at Infosys
It is a stable solution, which is why we chose it.
CIO at a venture capital & private equity firm with 11-50 employees
Continuous monitoring is crucial to ensure system stability and avoid vulnerabilities or threats.
Developer at a consultancy with 10,001+ employees
There are compatibility issues occasionally arising with false positives when other security tools are not whitelisted in Microsoft Defender.
information Security and IT Manager at Discover Dollar Technologies Pvt Ltd.
It is very resource-intensive, consuming a lot of memory and CPU.
Security Specialist at Prudential Systems Japan
If Microsoft experiences downtime, this solution goes down as it is a SaaS-based solution where we have no control.
Cloud Security Engineer at a computer software company with 51-200 employees
I would rate it a ten out of ten for stability.
Cloud Security Engineer (Team lead) at a tech services company with 201-500 employees
Most of the time, when the client requires data, it is not available.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
The cloud environment is dynamic, so the tool must be dynamic.
Cloud Security Delivery Associate Manager at Accenture
 

Room For Improvement

Users suggest enhancing Qualys TotalCloud with clearer reports, better integration, intuitive UI, AI risk assessments, and improved documentation.
Microsoft Defender Vulnerability Management needs simplified configuration, better integration, faster updates, and advanced features for improved security and efficiency.
Prisma Cloud struggles with integration, UI, automation, cloud coverage, reporting, support, and pricing, hindering broader adoption and usability.
Ideally, the scanner should automatically detect and scan all subdomains, even if not explicitly defined, ensuring comprehensive vulnerability assessment.
Analyst, Information Security at Infosys
Ideally, updates should be more immediate, enabling quicker implementation of solutions.
Project Lead at Persistent Systems
Our goal is to integrate all these functions into Qualys, creating a single dashboard for comprehensive security monitoring and management.
Senior Information Security Engineer at a consultancy with 10,001+ employees
This scoring should be for specific industries as well. If I belong to the healthcare industry using Microsoft Defender Vulnerability Management, it should provide me with a risk score and show how I fare against the risk score of my industry.
DGM. Technical Security at a tech services company with 10,001+ employees
A vulnerability I patch within 15 minutes takes 24 additional hours for an update.
information Security and IT Manager at Discover Dollar Technologies Pvt Ltd.
The product is not stable; it often uses excessive memory and CPU, which makes it slow.
Security Specialist at Prudential Systems Japan
Prisma Cloud is an excellent tool.
Technical Engineer at a tech services company with 1,001-5,000 employees
We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts.
Cyber Security Architect at a comms service provider with 10,001+ employees
Even though documentation was available, it took a while for a new person to understand what integration meant, what will be achieved after the integration, or how the integration needed to be done on the Azure or AWS side.
Technical Architect at a tech services company with 1,001-5,000 employees
 

Setup Cost

Qualys TotalCloud's pricing is high yet justified by comprehensive features and flexibility, benefiting larger enterprises seeking robust security.
Microsoft Defender Vulnerability Management offers competitive pricing in industry, though costs can be complex, especially for non-partners.
Prisma Cloud's complex pricing is offset by comprehensive features, offering cost efficiency with strategic planning despite hidden costs.
Qualys TotalCloud's pricing is currently acceptable, it is becoming increasingly expensive.
Senior Manager at a financial services firm with 10,001+ employees
Pricing is managed by our finance team; however, Qualys TotalCloud offers cost-effective licensing flexibility.
IT Manager at a consultancy with 10,001+ employees
Qualys TotalCloud is expensive, but it offers a premier solution with no headaches.
Vice President at Inspira Enterprise
Overall, every organization wishes for cheaper options, but we look at the security side as well, so we are good for now.
Senior Cloud Security Consultant at MetLife
For non-partners, however, the cost could be seen as higher, between seven to ten.
COO at Floating-Dot Technology LTD
The pricing is reasonable, and it's included in the whole Microsoft E5 bundle, so it's all-inclusive.
Corporate Planner at MISC Berhad
The cost was not on the higher side.
Technical Architect at a tech services company with 1,001-5,000 employees
If you are using a single tool like Prisma Cloud, with a single license, you can monitor all environments, such as Google Cloud, Azure, AWS, and Oracle Cloud.
Cloud Security Delivery Associate Manager at Accenture
The pricing for what we are using is pretty good.
Works at a pharma/biotech company with 10,001+ employees
 

Valuable Features

Qualys TotalCloud offers comprehensive vulnerability detection, cloud security management, and automation with insightful dashboards for efficient threat management.
Microsoft Defender offers asset discovery, real-time intelligence, seamless integration, risk prioritization, continuous monitoring, and proactive remediation with AI capabilities.
Prisma Cloud offers advanced cloud security with continuous monitoring, automation, and centralized management, enhancing operational efficiency across industries.
This view of risk helps reduce the work we would have to do to combine multiple sources to prioritize risk.
Works at a consultancy with 10,001+ employees
It will help cybersecurity professionals monitor the cloud and find vulnerabilities.
Developer at a consultancy with 10,001+ employees
We are enjoying the new feature, FlexScan, which is valuable for Internet-facing VMs.
Senior Consultant at a consultancy with 10,001+ employees
The main advantage of Microsoft Defender Vulnerability Management is that it can locate and prevent most threats even when the endpoints are not connected to the corporate network, as long as the internet is available.
DGM. Technical Security at a tech services company with 10,001+ employees
The feature for customizing to region-specific and domain-specific requirements in healthcare is particularly beneficial.
Cloud Security Engineer at a computer software company with 51-200 employees
The most valuable aspect is the kind of assessment results I get, and the recommendations provided in Microsoft products really help in taking care of the resources.
Senior Cloud Security Consultant at MetLife
It provides a single pane of glass.
enterprise architect at a tech services company with 1-10 employees
If I want to check how many of my S3s have encryption, I can write a Lambda function in Prisma Cloud and get that report.
Senior IT infrastructure consultant at a tech services company with 51-200 employees
Overall, the most valuable features for us in Prisma Cloud are those that provide visibility, ensure compliance with regulations, and help us align our on-premises servers and cloud environments with mandated security standards.
Architect at a tech vendor with 10,001+ employees
 

Categories and Ranking

Qualys TotalCloud
Sponsored
Average Rating
8.6
Reviews Sentiment
7.3
Number of Reviews
39
Ranking in other categories
Vulnerability Management (11th), Container Security (11th), Cloud Workload Protection Platforms (CWPP) (8th), Cloud Security Posture Management (CSPM) (8th), SaaS Security Posture Management (SSPM) (1st), Cloud-Native Application Protection Platforms (CNAPP) (6th)
Microsoft Defender Vulnerab...
Average Rating
8.2
Reviews Sentiment
6.4
Number of Reviews
18
Ranking in other categories
Vulnerability Management (13th), Advanced Threat Protection (ATP) (20th), Microsoft Security Suite (17th), Risk-Based Vulnerability Management (6th)
Prisma Cloud by Palo Alto N...
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
114
Ranking in other categories
Web Application Firewall (WAF) (8th), Container Security (2nd), Cloud Security Posture Management (CSPM) (2nd), Cloud-Native Application Protection Platforms (CNAPP) (2nd), Data Security Posture Management (DSPM) (2nd)
 

Mindshare comparison

Vulnerability Management Mindshare Distribution
ProductMindshare (%)
Microsoft Defender Vulnerability Management1.6%
Wiz4.5%
Qualys VMDR3.9%
Other90.0%
Vulnerability Management
Cloud-Native Application Protection Platforms (CNAPP) Mindshare Distribution
ProductMindshare (%)
Prisma Cloud by Palo Alto Networks10.7%
Wiz13.1%
Microsoft Defender for Cloud7.8%
Other68.4%
Cloud-Native Application Protection Platforms (CNAPP)
 

Featured Reviews

RO
IT Security Expert at Alior Bank S.A.
Unified risk scoring has improved our cloud visibility and simplifies remediation priorities
Qualys TotalCloud provides unified vulnerability and threat assessment across both IAS and SaaS. This solution provides a single prioritized view of risk, which helps reduce the work I would have to do. We are no longer based on CVSS; we are based on Qualys risk scoring, which is based on CVSS plus internal findings made by Qualys, and then assigns its own score. The TruRisk insight feature has found a small number of assets with high vulnerability scores, though I am cautious since some information is classified. Qualys TotalCloud has positively impacted our bank's performance, and we have definitely seen benefits after implementing this solution.
reviewer2770602 - PeerSpot reviewer
Cloud Security Engineer at a computer software company with 51-200 employees
Has helped with regional threat monitoring but needs better documentation and real-time capabilities
The documentation from Microsoft needs significant improvement. The documents are disorganized, with one document linking to another, making the steps unclear and difficult to follow. Regarding updates, it is not truly real-time as it takes between eight to twelve hours for updates to occur. It would be beneficial if updates could happen more quickly, perhaps within 10 minutes to half an hour. Support for integration and documentation needs to be more straightforward. The pricing is expensive, even though it is part of the E5 package.
reviewer2776578 - PeerSpot reviewer
Cyber Security Architect at a comms service provider with 10,001+ employees
Image scanning has supported consistent security practices during cloud deployment
On a scale of ten, we would say people are happy with Prisma Cloud by Palo Alto Networks for the part we use. People are okay with it. We probably would give an eight. We don't give ten because if we don't use the other parts of Prisma Cloud by Palo Alto Networks, it's because it was difficult to implement from an operational point of view. We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts. People have other tools and in the end, we don't use the full capabilities of a product that we pay for. It's partially related to the difficulty to integrate Prisma Cloud by Palo Alto Networks runtime in our company's support process. We don't use the real-time monitoring part of Prisma Cloud by Palo Alto Networks. We don't know about the automated remediation feature of Prisma Cloud by Palo Alto Networks.
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Top Industries

By visitors reading reviews
Manufacturing Company
18%
Financial Services Firm
13%
Construction Company
7%
Comms Service Provider
6%
Financial Services Firm
12%
Manufacturing Company
10%
Computer Software Company
7%
Government
7%
Financial Services Firm
14%
Computer Software Company
9%
Manufacturing Company
9%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise3
Large Enterprise29
By reviewers
Company SizeCount
Small Business9
Midsize Enterprise2
Large Enterprise8
By reviewers
Company SizeCount
Small Business37
Midsize Enterprise21
Large Enterprise57
 

Questions from the Community

What needs improvement with Qualys TotalCloud?
Areas that need improvement in every solution include the remediation part. The remediation steps should be simple en...
What is your primary use case for Qualys TotalCloud?
Our use case involves the assets that we have under cloud, the assets exposed to the internet, and the internal appli...
What needs improvement with Microsoft Defender Vulnerability Management?
Configuration of Microsoft Defender Vulnerability Management is something that needs improvement. In future updates o...
What is your primary use case for Microsoft Defender Vulnerability Management?
I can control the applications using Microsoft Defender Vulnerability Management, which are its best features for me ...
What is your primary use case for Prisma Cloud by Palo Alto Networks?
Prisma Cloud helps support DevSecOps methodologies, making those responsibilities easier to manage.
What Cloud-Native Application Protection Platform do you recommend?
We like Prisma Cloud by Palo Alto Networks, since it offers us incredible visibility into our entire cloud system. We...
What do you think of Aqua Security vs Prisma Cloud?
Aqua Security is easy to use and very manageable. Its main focus is on Kubernetes and Docker. Security is a very valu...
 

Also Known As

Qualys TotalCloud with FlexScan
No data available
Prisma Public Cloud, RedLock Cloud 360, RedLock, Twistlock, Aporeto
 

Overview

 

Sample Customers

Information Not Available
Information Not Available
Amgen, Genpact, Western Asset, Zipongo, Proofpoint, NerdWallet, Axfood, 21st Century Fox, Veeva Systems, Reinsurance Group of America
Find out what your peers are saying about Wiz, Tenable, Qualys and others in Vulnerability Management. Updated: June 2026.
900,196 professionals have used our research since 2012.