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Microsoft Defender vs Prisma Cloud by Palo Alto Networks comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Feb 1, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
5.5
Qualys TotalCloud boosts efficiency, reduces manual effort, decreases risk, and offers significant cost savings with a notable ROI.
Sentiment score
7.1
Microsoft Defender for Cloud enhances ROI by improving security, productivity, and cost efficiency, despite perceived licensing costs.
Sentiment score
6.9
Prisma Cloud boosts productivity, enhances security, and delivers high ROI by automating processes and reducing manual testing needs.
It has saved about 90% of our time.
Senior Consultant at a consultancy with 10,001+ employees
TotalCloud has generated overall savings of 30 to 40 percent across various departments.
Security Manager at a consultancy with 10,001+ employees
CallStream helps us integrate and automate tasks.
Senior Security Consultant at CyberNxt Solutions LLP
Defender proactively indexes and analyzes documents, identifying potential threats even when inactive, enhancing preventative security.
Endpoint management at a government with 10,001+ employees
Identifying potential vulnerabilities has helped us avoid costly data losses.
Manager at CBTS
Compared to not having Microsoft Defender for Cloud in place, we definitely saw an advantage by not having downtime due to a security threat.
Principal Microsoft Consultant at MicroAge
It eliminates the need for additional hardware, making it a financially and technically sound investment.
Partner at Quasys
Reputation and data security are the two most important things to a financial institution.
Works at a comms service provider with 1-10 employees
We may have prevented a security breach with remediation of the findings.
Security Solutions Architect - Cloud Security Consultant at a consultancy with 10,001+ employees
 

Customer Service

Sentiment score
7.4
Qualys TotalCloud support is praised for efficiency and staff knowledge but criticized for delays and inconsistent quality.
Sentiment score
6.3
Microsoft Defender for Cloud support is knowledgeable with effective documentation, but first-tier delays impact overall satisfaction.
Sentiment score
7.1
Palo Alto Networks' technical support is praised for responsiveness, though regional inconsistencies and response time improvements are noted.
They are helpful, respond to my queries, and can answer any question.
Developer at a consultancy with 10,001+ employees
Qualys's tech support is highly responsive, providing multiple ways to interact with them.
Service Manager, Security Operations at CDA IT SOLUTIONS
Qualys' customer service provides quality answers, but the response time is long, even though it is within the SLA.
Works at a consultancy with 10,001+ employees
Since security is critical, we prefer a quicker response time.
Manager at CBTS
The support team was very responsive to queries.
Programme Manager- Cyber Fusion- Group CISO at a financial services firm with 10,001+ employees
They understand their product, but much like us, they struggle with the finer details, especially with new features.
Endpoint management at a government with 10,001+ employees
They can respond with technical documentation or pass on the case to the next level because it requires the development of a new feature or changing a feature due to a bug.
Technical Lead at a consultancy with 11-50 employees
Anywhere we raise a tech case, they revert back within an hour.
Cloud Security Engineer at a tech vendor with 201-500 employees
I would give them 10 out of 10.
Sector Manager at a comms service provider with 51-200 employees
 

Scalability Issues

Sentiment score
7.8
Qualys TotalCloud excels in scalability, efficiently supporting diverse environments and business sizes, though it may require skilled management.
Sentiment score
7.5
Microsoft Defender for Cloud is highly scalable, seamlessly integrates across platforms, and efficiently handles growth, with room for feature improvement.
Sentiment score
7.6
Prisma Cloud offers scalable, flexible multi-cloud solutions with easy deployment, strong automation, API support, and high scalability ratings.
We started our organization about nine months back. We started with about 30 users, and we now have more than 100 users.
CIO at a venture capital & private equity firm with 11-50 employees
Our organization currently uses it to manage over 1200 web applications.
Analyst, Information Security at Infosys
It is absolutely scalable, and I would rate its scalability as nine out of ten.
retired at a consultancy with 10,001+ employees
As we have reduced our on-premises infrastructure, it is about how we can migrate workloads to the cloud to make it easier, and then having everything fully encompassed and secured within that area makes it much easier for us to scale as needed and grow.
Principal Microsoft Consultant at MicroAge
We are using infrastructure as a code, so we do not have any scalability issues with Microsoft Defender for Cloud implementation because our cloud automatically does it.
Senior Cloud Platform Engineer at Deutsche Börse
It has multiple licenses and features, covering infrastructures from a hundred to five hundred virtual machines, without any issues.
Snr. Infrastructure Architect (Data Centre) at LogicEra
Scalability-wise, I rate the solution a nine out of ten.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
We haven't had any issues scaling the solution.
Senior Cloud Security Engineer at impelsys
There aren't any limits to Prisma Cloud's scalability.
Senior Security Consultant at helpag
 

Stability Issues

Sentiment score
8.3
Qualys TotalCloud is highly stable with reliable support, 99.9% uptime, minimal bugs, and effective maintenance communication.
Sentiment score
7.6
Microsoft Defender for Cloud is stable and reliable, though minor update issues occur with older systems and internet latency.
Sentiment score
7.9
Prisma Cloud is praised for its high stability, reliability, and effective troubleshooting, with minor well-managed issues.
Overall, the support provided has been excellent.
Analyst, Information Security at Infosys
It is a stable solution, which is why we chose it.
CIO at a venture capital & private equity firm with 11-50 employees
Continuous monitoring is crucial to ensure system stability and avoid vulnerabilities or threats.
Developer at a consultancy with 10,001+ employees
Defender's stability has been flawless for us.
Engineer at a computer software company with 201-500 employees
I have not experienced any crashes or downtime.
Head Of IT at Cirrus Response
Microsoft Defender for Cloud is very stable.
Cloud architect at a tech vendor with 1,001-5,000 employees
I would rate it a ten out of ten for stability.
Cloud Security Engineer (Team lead) at a tech services company with 201-500 employees
Most of the time, when the client requires data, it is not available.
Technology Specialist - Cloud Security at a tech services company with 11-50 employees
The cloud environment is dynamic, so the tool must be dynamic.
Cloud Security Delivery Associate Manager at Accenture
 

Room For Improvement

Users suggest enhancing Qualys TotalCloud with clearer reports, better integration, intuitive UI, AI risk assessments, and improved documentation.
Microsoft Defender for Cloud needs improved customization, automation, UI performance, policy management, integration, AI functions, and reduced licensing complexities.
Prisma Cloud struggles with integration, UI, automation, cloud coverage, reporting, support, and pricing, hindering broader adoption and usability.
Ideally, the scanner should automatically detect and scan all subdomains, even if not explicitly defined, ensuring comprehensive vulnerability assessment.
Analyst, Information Security at Infosys
Ideally, updates should be more immediate, enabling quicker implementation of solutions.
Project Lead at Persistent Systems
Our goal is to integrate all these functions into Qualys, creating a single dashboard for comprehensive security monitoring and management.
Senior Information Security Engineer at a consultancy with 10,001+ employees
Microsoft, in general, could significantly improve its communication and support.
Endpoint management at a government with 10,001+ employees
It would be beneficial to streamline recommendations to avoid unnecessary alerts and to refine the severity of alerts based on specific environments or environmental attributes.
Works at Coca-Cola HBC
The artificial intelligence features could be expanded to allow the system to autonomously manage security issues without needing intervention from admins.
Cloud Consultant at i-Community AG
Prisma Cloud is an excellent tool.
Technical Engineer at a tech services company with 1,001-5,000 employees
We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts.
Cyber Security Architect at a comms service provider with 10,001+ employees
Even though documentation was available, it took a while for a new person to understand what integration meant, what will be achieved after the integration, or how the integration needed to be done on the Azure or AWS side.
Technical Architect at a tech services company with 1,001-5,000 employees
 

Setup Cost

Qualys TotalCloud's pricing is high yet justified by comprehensive features and flexibility, benefiting larger enterprises seeking robust security.
Microsoft Defender for Cloud offers flexible pricing but gets complex and costly, requiring careful evaluation, especially for advanced plans.
Prisma Cloud's complex pricing is offset by comprehensive features, offering cost efficiency with strategic planning despite hidden costs.
Qualys TotalCloud's pricing is currently acceptable, it is becoming increasingly expensive.
Senior Manager at a financial services firm with 10,001+ employees
Pricing is managed by our finance team; however, Qualys TotalCloud offers cost-effective licensing flexibility.
IT Manager at a consultancy with 10,001+ employees
Qualys TotalCloud is expensive, but it offers a premier solution with no headaches.
Vice President at Inspira Enterprise
Security has essentially no cost when compared to the cost of a breach.
Director, Cloud and Modern Workplace at Informanix Technology Group
Every time we consider expanding usage, we carefully evaluate the necessity due to cost concerns.
Programme Manager- Cyber Fusion- Group CISO at a financial services firm with 10,001+ employees
We appreciate the licensing approach based on employee count rather than a big enterprise license.
Manager, Microsoft Technology Alliance at Silverfort
The cost was not on the higher side.
Technical Architect at a tech services company with 1,001-5,000 employees
If you are using a single tool like Prisma Cloud, with a single license, you can monitor all environments, such as Google Cloud, Azure, AWS, and Oracle Cloud.
Cloud Security Delivery Associate Manager at Accenture
Prisma's price is pretty high, but it's a good product, and you get what you paid for, especially if you're working in a containerized environment.
Cloud Security Engineer at Fast
 

Valuable Features

Qualys TotalCloud offers comprehensive vulnerability detection, cloud security management, and automation with insightful dashboards for efficient threat management.
Microsoft Defender for Cloud enhances security and compliance with AI-powered threat intelligence, automation, and multi-cloud integration for improved protection.
Prisma Cloud offers advanced cloud security with continuous monitoring, automation, and centralized management, enhancing operational efficiency across industries.
This view of risk helps reduce the work we would have to do to combine multiple sources to prioritize risk.
Works at a consultancy with 10,001+ employees
It will help cybersecurity professionals monitor the cloud and find vulnerabilities.
Developer at a consultancy with 10,001+ employees
We are enjoying the new feature, FlexScan, which is valuable for Internet-facing VMs.
Senior Consultant at a consultancy with 10,001+ employees
The most valuable feature for me is the variety of APIs available.
Programme Manager- Cyber Fusion- Group CISO at a financial services firm with 10,001+ employees
This feature significantly aids in threat detection and enhances the user experience by streamlining security management.
Cloud Consultant at i-Community AG
The most valuable feature is the recommendations provided on how to improve security.
Cloud architect at a tech vendor with 1,001-5,000 employees
It provides a single pane of glass.
enterprise architect at a tech services company with 1-10 employees
If I want to check how many of my S3s have encryption, I can write a Lambda function in Prisma Cloud and get that report.
Senior IT infrastructure consultant at a tech services company with 51-200 employees
Overall, the most valuable features for us in Prisma Cloud are those that provide visibility, ensure compliance with regulations, and help us align our on-premises servers and cloud environments with mandated security standards.
Architect at a tech vendor with 10,001+ employees
 

Categories and Ranking

Qualys TotalCloud
Sponsored
Ranking in Container Security
13th
Ranking in Cloud Security Posture Management (CSPM)
8th
Ranking in Cloud-Native Application Protection Platforms (CNAPP)
8th
Average Rating
8.6
Reviews Sentiment
7.3
Number of Reviews
39
Ranking in other categories
Vulnerability Management (11th), Cloud Workload Protection Platforms (CWPP) (9th), SaaS Security Posture Management (SSPM) (1st)
Microsoft Defender for Cloud
Ranking in Container Security
5th
Ranking in Cloud Security Posture Management (CSPM)
4th
Ranking in Cloud-Native Application Protection Platforms (CNAPP)
4th
Average Rating
8.0
Reviews Sentiment
6.9
Number of Reviews
89
Ranking in other categories
Vulnerability Management (5th), Container Management (6th), Cloud Workload Protection Platforms (CWPP) (1st), Data Security Posture Management (DSPM) (5th), Microsoft Security Suite (7th), Compliance Management (4th), Cloud Detection and Response (CDR) (3rd)
Prisma Cloud by Palo Alto N...
Ranking in Container Security
2nd
Ranking in Cloud Security Posture Management (CSPM)
2nd
Ranking in Cloud-Native Application Protection Platforms (CNAPP)
2nd
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
114
Ranking in other categories
Web Application Firewall (WAF) (9th), Data Security Posture Management (DSPM) (2nd)
 

Mindshare comparison

As of May 2026, in the Cloud-Native Application Protection Platforms (CNAPP) category, the mindshare of Qualys TotalCloud is 1.8%, up from 1.3% compared to the previous year. The mindshare of Microsoft Defender for Cloud is 8.1%, down from 11.5% compared to the previous year. The mindshare of Prisma Cloud by Palo Alto Networks is 11.0%, down from 17.3% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Cloud-Native Application Protection Platforms (CNAPP) Mindshare Distribution
ProductMindshare (%)
Prisma Cloud by Palo Alto Networks11.0%
Microsoft Defender for Cloud8.1%
Qualys TotalCloud1.8%
Other79.1%
Cloud-Native Application Protection Platforms (CNAPP)
 

Featured Reviews

RO
IT Security Expert at Alior Bank S.A.
Unified risk scoring has improved our cloud visibility and simplifies remediation priorities
Qualys TotalCloud provides unified vulnerability and threat assessment across both IAS and SaaS. This solution provides a single prioritized view of risk, which helps reduce the work I would have to do. We are no longer based on CVSS; we are based on Qualys risk scoring, which is based on CVSS plus internal findings made by Qualys, and then assigns its own score. The TruRisk insight feature has found a small number of assets with high vulnerability scores, though I am cautious since some information is classified. Qualys TotalCloud has positively impacted our bank's performance, and we have definitely seen benefits after implementing this solution.
RW
Head Of IT at Cirrus Response
Cloud security has cut investigation time and now reveals threats faster but needs simpler oversight
When deploying AI applications, my key security concerns with Microsoft Defender for Cloud are data loss, leakage of data, and guardrails around the actual AI, and I am hoping that this is going to help me put those guardrails in place and identify data exfiltration. Microsoft Defender for Cloud has not helped me manage and secure multi-cloud environments, as we are 100 percent Microsoft and have not really got it in any other environment at all. I am not yet using the unified AI-powered security feature offered by Microsoft Defender for Cloud, but that is coming. I am not yet using the integrated XDR feature of Microsoft Defender for Cloud, but that is coming. I am not yet utilizing the GenAI threat protection features of Microsoft Defender for Cloud. That is also coming and a lot of that will come from learning it here. I have enabled the agentless scanning in my cloud environment with Microsoft Defender for Cloud. Assessing the impact on my workload protection without needing to install agents with Microsoft Defender for Cloud makes it a lot easier, but it also identifies a lot more, which puts more load on me sometimes. I would advise another organization considering Microsoft Defender for Cloud that it is the most logical route to follow if their whole ecosystem is Microsoft. It is easy to implement and it is very self-explanatory when doing it, making sense to just follow the steps as it is too simple, really. I would rate this review a 7.5 out of 10.
reviewer2776578 - PeerSpot reviewer
Cyber Security Architect at a comms service provider with 10,001+ employees
Image scanning has supported consistent security practices during cloud deployment
On a scale of ten, we would say people are happy with Prisma Cloud by Palo Alto Networks for the part we use. People are okay with it. We probably would give an eight. We don't give ten because if we don't use the other parts of Prisma Cloud by Palo Alto Networks, it's because it was difficult to implement from an operational point of view. We could have deployed the runtime monitoring with Prisma Cloud by Palo Alto Networks, but within our organization at our company, it was very difficult to find who would be the owner for the alerts. People have other tools and in the end, we don't use the full capabilities of a product that we pay for. It's partially related to the difficulty to integrate Prisma Cloud by Palo Alto Networks runtime in our company's support process. We don't use the real-time monitoring part of Prisma Cloud by Palo Alto Networks. We don't know about the automated remediation feature of Prisma Cloud by Palo Alto Networks.
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Top Industries

By visitors reading reviews
Financial Services Firm
16%
Computer Software Company
10%
Manufacturing Company
9%
Government
8%
Financial Services Firm
12%
Computer Software Company
10%
Manufacturing Company
9%
Government
6%
Financial Services Firm
15%
Computer Software Company
9%
Manufacturing Company
9%
Government
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business10
Midsize Enterprise3
Large Enterprise28
By reviewers
Company SizeCount
Small Business30
Midsize Enterprise13
Large Enterprise49
By reviewers
Company SizeCount
Small Business38
Midsize Enterprise20
Large Enterprise57
 

Questions from the Community

What needs improvement with Qualys TotalCloud?
Areas that need improvement in every solution include the remediation part. The remediation steps should be simple en...
What is your primary use case for Qualys TotalCloud?
Our use case involves the assets that we have under cloud, the assets exposed to the internet, and the internal appli...
How is Prisma Cloud vs Azure Security Center for security?
Azure Security Center is very easy to use, integrates well, and gives very good visibility on what is happening acros...
What is your experience regarding pricing and costs for Microsoft Defender for Cloud?
My experience with pricing, setup costs, and licensing was that the license cost was the only consideration. Setup an...
What needs improvement with Microsoft Defender for Cloud?
To improve Microsoft Defender for Cloud, I think pricing-wise, the license price is a little bit higher from an inges...
What is your primary use case for Prisma Cloud by Palo Alto Networks?
Prisma Cloud helps support DevSecOps methodologies, making those responsibilities easier to manage.
What Cloud-Native Application Protection Platform do you recommend?
We like Prisma Cloud by Palo Alto Networks, since it offers us incredible visibility into our entire cloud system. We...
What do you think of Aqua Security vs Prisma Cloud?
Aqua Security is easy to use and very manageable. Its main focus is on Kubernetes and Docker. Security is a very valu...
 

Also Known As

Qualys TotalCloud with FlexScan
Microsoft Azure Security Center, Azure Security Center, Microsoft ASC, Azure Defender
Prisma Public Cloud, RedLock Cloud 360, RedLock, Twistlock, Aporeto
 

Interactive Demo

Demo not available
Demo not available
 

Overview

 

Sample Customers

Information Not Available
Microsoft Defender for Cloud is trusted by companies such as ASOS, Vatenfall, SWC Technology Partners, and more.
Amgen, Genpact, Western Asset, Zipongo, Proofpoint, NerdWallet, Axfood, 21st Century Fox, Veeva Systems, Reinsurance Group of America
Find out what your peers are saying about Microsoft Defender for Cloud vs. Prisma Cloud by Palo Alto Networks and other solutions. Updated: April 2026.
895,399 professionals have used our research since 2012.