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Microsoft Defender for Cloud Apps vs ThreatLocker Zero Trust Endpoint Protection Platform comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Oct 5, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.7
Microsoft Defender for Cloud Apps enhances security, reduces costs by 35-45%, and improves uptime with efficient cloud application management.
Sentiment score
7.9
ThreatLocker Zero Trust Platform enhances security, improves efficiency, saves costs, increases revenue, and supports business growth by reducing threats.
The biggest return on investment so far has been visibility, knowing what we have in our environment.
As a small team, Microsoft Defender for Cloud Apps allowed us to manage systems with just one or two people.
We have at least saved the costs we had from the Netskope solution this year.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
It keeps malware, Trojans, and ransomware at bay.
 

Customer Service

Sentiment score
7.0
Microsoft Defender for Cloud Apps support is generally good, but users suggest faster responses and improved communication.
Sentiment score
7.7
ThreatLocker Zero Trust's responsive customer service, highlighted by the Cyber Hero program, is praised for speed, professionalism, and effectiveness.
Their customer service is pretty good, but it's frustrating to go through three or four channels before reaching the right person.
The support is excellent, and the speed of response is commendable.
There were instances where the engineers were knowledgeable and helpful, but at other times it felt like a ping pong game, with unnecessary transfers until the right person was found.
They have been very responsive, helpful, and knowledgeable.
I would rate their customer support a ten out of ten.
Their support is world-class.
 

Scalability Issues

Sentiment score
7.6
Microsoft Defender for Cloud Apps offers scalable security, efficiently managing large user bases and app integrations with centralized management.
Sentiment score
8.0
ThreatLocker Zero Trust Platform offers seamless scalability and adaptability, efficiently managing diverse environments and dynamic growth across endpoints.
For what I know about the log collector and how much data it can take in, it is super scalable and capable of handling high workloads.
Microsoft Defender for Cloud Apps is very scalable, provided you have the right subscription.
In my experience, Microsoft Defender for Cloud Apps is good enough for small to medium businesses.
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
I would rate it a ten out of ten for scalability.
 

Stability Issues

Sentiment score
8.1
Microsoft Defender for Cloud Apps is praised for high reliability, minimal downtime, consistent performance, and swift issue resolution.
Sentiment score
7.4
ThreatLocker Zero Trust Platform is praised for stability and reliability, with minor issues swiftly addressed by support.
I would rate it a ten because I have not experienced any stability issues so far with Defender for Cloud Apps.
I would assess the stability and reliability of Microsoft Defender for Cloud Apps as stable
My impression on the stability and reliability of Microsoft Defender for Cloud Apps is that it is very stable.
For five years, we have not had a problem.
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
It has been very stable, reliable, and accessible.
 

Room For Improvement

Microsoft Defender for Cloud Apps could improve integration, pricing, support, reporting, automation, alerts, and overall user experience across multi-cloud environments.
ThreatLocker needs UI improvements, better integrations, expanded training, enhanced analytics, restricted Learning Mode, and faster support.
For data loss prevention, it would be useful to be able to drill down into the kind of data being transferred over CloudApp.
Defender typically connects to Entra ID, but we have local users on the cloud for database access, SSH, or RDS, and there is nothing produced by Defender regarding those local IAM users.
A significant improvement I would like to see is the integration into a single pane of glass.
Controlling the cloud environment, not just endpoints, is crucial.
This is problematic when immediate attention is needed.
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
 

Setup Cost

Microsoft Defender for Cloud Apps is cost-effective within Microsoft 365 bundles, especially for large organizations with discounts available.
Enterprise buyers find ThreatLocker's pricing competitive and flexible, valuing its affordability, transparency, and accessible setup costs.
The pricing for Microsoft Defender for Cloud Apps is acceptable.
My organization is currently revisiting pricing, but previously, the cost was a bit expensive, yet comparable to other solutions with similar functionalities and features.
It's not the cheapest, but also not the most expensive, placing it in the mid-level range.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
I had a really good deal at the time, and it continues to be cost-effective.
 

Valuable Features

Microsoft Defender for Cloud Apps offers integration, threat detection, and management, enhancing security with comprehensive visibility and proactive assessment.
ThreatLocker Zero Trust Platform enhances security with features like application control, selective elevation, and robust network access controls.
The ability to sanction unsanctioned apps using Secure Score benchmarking, included in Cloud, is also beneficial.
Microsoft Defender for Cloud Apps is very comprehensive, providing a complete 360-degree view of applications within an organization.
The most valuable features of Microsoft Defender for Cloud Apps include live, up-to-date information, which provided real-time alerts.
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
It protects our customers.
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
 

Categories and Ranking

Microsoft Defender for Clou...
Ranking in Advanced Threat Protection (ATP)
14th
Average Rating
8.4
Reviews Sentiment
7.3
Number of Reviews
40
Ranking in other categories
Cloud Access Security Brokers (CASB) (4th), Microsoft Security Suite (12th)
ThreatLocker Zero Trust End...
Ranking in Advanced Threat Protection (ATP)
6th
Average Rating
9.2
Reviews Sentiment
7.4
Number of Reviews
40
Ranking in other categories
Network Access Control (NAC) (5th), Endpoint Protection Platform (EPP) (7th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
 

Mindshare comparison

As of October 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Cloud Apps is 1.8%, up from 1.4% compared to the previous year. The mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 3.1%, up from 2.2% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP) Market Share Distribution
ProductMarket Share (%)
ThreatLocker Zero Trust Endpoint Protection Platform3.1%
Microsoft Defender for Cloud Apps1.8%
Other95.1%
Advanced Threat Protection (ATP)
 

Featured Reviews

Abdulrahman Muhammadi - PeerSpot reviewer
Integration with existing cloud workflows has simplified compliance and threat detection
Licensing cost is a significant concern. With Defender Plan 1, Microsoft Defender for Cloud Apps comes with a pay-per-use model. Each feature has its own pricing when activated on VMs. For example, the vulnerability assessment has separate pricing, the base model including encryptions has separate pricing, and the compliance features have separate pricing. This applies to each VM and Azure resource individually. It is not straightforward where you can take one license and apply it to everything. Each feature has its own pricing model which can be tedious, as the costs keep accumulating. The only lacking feature currently is XDR (extended detection and response). Apart from that, I have only positive experiences with the whole Microsoft suite, except for the pricing structure.
Johnathan Bodily - PeerSpot reviewer
Ensures ransomware protection and reduces phishing chaos
The application control has been great so far, and while I am still exploring the network access controls, I unfortunately don't have access to one module I would love to have due to licensing restrictions. It's easy to use in regard to reducing attack surfaces. For me, it's a piece of cake. We can have something approved within 30 seconds, thanks to the mobile app. We haven't eliminated security solutions. We just add to it, and ThreatLocker has been a great addition. We also have Kaseya and ThreatLocker as a supplement to that. It's useful. They have overlap, and we look at the overlap as a good thing. It's helped your organization save on operational costs or expenses by ensuring that many fewer hours are spent dealing with ransomware nonsense. I cannot count the amount of hours that I personally have not had to put in to recovering an environment from a ransomware event. The last big one took us about three weeks to completely recover from. Since we've grouped ThreatLocker in, the management of that whole setup has gone down to just daily help desk tasks and general server maintenance instead of having the whole system on fire. There are probably thousands of hours of saved time between our teams. It's been great so far. ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications is great. It's my biggest protection, the blocked applications. In a lot of cases, you go to install something yourself that you need for management, and it comes in and says, nope. And then I have to log into the portal and approve it. I get our other guys saying, hey, why are you trying to approve something? Any of the tools that I'm using on a day-to-day basis that haven't been in the environment during the whole learning mode initially, I could go through and set extensions and all that. So, while it's a headache on that end, the amount of saved time I can't even count. It is a little frustrating on my end since I like to go as quickly as I possibly can, and it slows me down. However, that's a really good thing. Depending on the site, it can save a lot of time and cut down headaches. It's likely saved a week's worth of time. It's cut down the amount of sever help desk tickets. Those have become minimal.
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Top Industries

By visitors reading reviews
Computer Software Company
12%
Financial Services Firm
10%
Manufacturing Company
9%
Government
7%
Computer Software Company
28%
Retailer
9%
Manufacturing Company
7%
Financial Services Firm
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business13
Midsize Enterprise10
Large Enterprise18
By reviewers
Company SizeCount
Small Business32
Midsize Enterprise4
Large Enterprise3
 

Questions from the Community

Which is the better security solution - Cisco Umbrella or Microsoft Cloud App Security?
Cisco Umbrella is an integral component of the Cisco SASE architecture. It integrates security in a single, cloud-native solution, unifying multiple features like DNS-layer security, threat intelli...
What do you like most about Microsoft Cloud App Security?
It does a great job of monitoring and maintaining a security baseline. For us, that is a key element. The notifications are pretty good.
What is your experience regarding pricing and costs for Microsoft Cloud App Security?
At the time of implementation, when the size of our organization was small, it was a more affordable product. Since all our productivity applications were on O365, Microsoft Defender for Cloud Apps...
What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
For the space that it's in, it's already there. I don't know of another product that compares to its level. Even recently, with the addition of the detect module is a very nice add-on to the packet...
 

Also Known As

MS Cloud App Security, Microsoft Cloud App Security
Protect, Allowlisting, Network Control, Ringfencing
 

Overview

 

Sample Customers

Customers for Microsoft Defender for Cloud Apps include Accenture, St. Luke’s University Health Network, Ansell, and Nakilat.
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Find out what your peers are saying about Microsoft Defender for Cloud Apps vs. ThreatLocker Zero Trust Endpoint Protection Platform and other solutions. Updated: September 2025.
869,566 professionals have used our research since 2012.