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Microsoft Defender vs Palo Alto Networks WildFire comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Apr 20, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.4
Organizations saw increased productivity, cost savings, and enhanced security with Microsoft Defender for Office 365's advanced features.
Sentiment score
7.5
Palo Alto Networks WildFire efficiently prevents threats, reduces costs significantly, and integrates seamlessly for comprehensive real-time security.
It has also decreased our time to detection and response by about 15 to 20 percent.
The service generates a low rate of false positives, reducing the overhead of managing false positive events.
 

Customer Service

Sentiment score
6.9
Microsoft Defender for Office 365 support is praised for responsiveness but has inconsistencies, especially in first-level assistance.
Sentiment score
7.3
Palo Alto Networks WildFire support excels for large companies, with varied quality and responsiveness for others, depending on region.
Any issues are addressed quickly by Microsoft's support.
Customer service and support have been fantastic.
There is a lack of SLA adherence, and third-party partners do not provide prompt responses.
The support is quite difficult to access promptly.
The service response times are aligned with standards, responding within a few hours based on the problem's criticality.
 

Scalability Issues

Sentiment score
8.1
Microsoft Defender for Office 365 scales effectively, seamlessly expanding capacity with minimal maintenance, suitable for large and growing organizations.
Sentiment score
8.2
Palo Alto Networks WildFire excels in adaptability, scalability, and seamless integration, meeting diverse organizational demands and high-performance standards.
We have never faced scalability problems, and Microsoft manages it effectively.
Palo Alto Networks WildFire is scalable, and I give it a nine for scalability.
Wildfire is highly scalable.
 

Stability Issues

Sentiment score
7.7
Microsoft Defender for Office 365 is reliable, with 99.9% availability and efficient bug fixes, offering seamless performance and stability.
Sentiment score
8.4
Palo Alto Networks WildFire is highly reliable, stable, and efficient, excelling in large-scale deployments and seamless cloud integration.
The solution is stable, as we have been using it for the past two years.
 

Room For Improvement

Microsoft Defender for Office 365 needs enhanced threat detection, integration, support, usability, documentation, and transparent pricing to address customer concerns.
Palo Alto Networks WildFire needs improvements in cost, user interface, ease of deployment, integration, detection capabilities, and support efficiency.
Microsoft could improve by offering recommendations for domain spoofing attacks, especially scenarios where DNS records like SPF, DKIM, and DMARC are not properly published.
The main area for improvement is simplifying the implementation and rollout process.
I would reduce the cost.
The dashboard should provide better visibility, especially in showing how many files are sent to Wildfire and their findings.
The support could be improved, as it takes a while to get assistance from the vendors.
 

Setup Cost

Microsoft Defender for Office 365, often pricey for SMEs, offers extensive security features with complex user-based licensing.
Palo Alto Networks WildFire is valued for advanced security despite high costs, preferred by enterprises but challenging for smaller firms.
Money-wise, it is a part of the Office 365 suite, making it slightly more expensive compared to Trend Micro.
Microsoft is quite affordable with a lot of features available for any size organization.
I would rate it an eight out of ten in terms of affordability.
 

Valuable Features

Microsoft Defender for Office 365 offers integrated protection with features like anti-malware and threat detection, enhancing security through AI.
WildFire offers sandboxing, App-ID, and automation, excelling in threat detection with real-time updates and seamless integration.
It provides end-to-end visibility on email threats such as phishing, extending beyond Exchange Online Protection.
It ranks the threats and allows us to prioritize those hitting us the hardest, such as email threats.
Microsoft Defender for Office 365 is now part of a centralized tenant for my entire group.
Integrating Palo Alto Networks WildFire with various security protocols similar to a firewall has significantly improved the overall threat detection capabilities in our organization.
The most valuable feature of Wildfire is its sandboxing capability for examining suspicious files or locations.
 

Categories and Ranking

Microsoft Defender for Offi...
Ranking in Advanced Threat Protection (ATP)
1st
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
49
Ranking in other categories
Email Security (1st), Microsoft Security Suite (11th)
Palo Alto Networks WildFire
Ranking in Advanced Threat Protection (ATP)
3rd
Average Rating
8.4
Reviews Sentiment
7.3
Number of Reviews
69
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of May 2025, in the Advanced Threat Protection (ATP) category, the mindshare of Microsoft Defender for Office 365 is 8.8%, down from 14.2% compared to the previous year. The mindshare of Palo Alto Networks WildFire is 12.3%, up from 12.4% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Advanced Threat Protection (ATP)
 

Featured Reviews

Tolu Omolaja - PeerSpot reviewer
Great URL scanning and attachment scanning, but I would like more proactive threat analysis
The two main features that prove most beneficial for us are URL scanning and attachment scanning. URL scanning involves an automatic scan of links and emails. When a user clicks on a link within an email, the system promptly checks the link's safety. If the link is deemed safe, access is granted automatically. However, if it is flagged as unsafe, we receive feedback and notification to caution us about the potentially harmful link. At this point, we are presented with the option to proceed or return. I have personally witnessed the system identify a few unsafe links, making this the primary advantage of using the solution. The second crucial aspect is the scanning of attachments. When an email containing an attachment arrives, we receive a notification of the new email, along with information that the attachment is being scanned for threats. This additional layer of security provides peace of mind for our organization. While Microsoft Defender for Office 365 offers numerous features, these two stand out as particularly impressive and valuable to us.
AjayKumar17 - PeerSpot reviewer
Enhanced cybersecurity with advanced sandboxing and effective in controlling DNS issues
Improvements are needed in the UI part. The dashboard should provide better visibility, especially in showing how many files are sent to Wildfire and their findings. This information should be integrated with the Dashboard so that system admins can see what is happening. Furthermore, technical support needs a lot of improvement, particularly in terms of responsiveness and adhering to service level agreements.
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Comparison Review

it_user206346 - PeerSpot reviewer
Mar 11, 2015
Cisco ASA vs. Palo Alto Networks
Cisco ASA vs. Palo Alto: Management Goodies You often have comparisons of both firewalls concerning security components. Of course, a firewall must block attacks, scan for viruses, build VPNs, etc. However, in this post I am discussing the advantages and disadvantages from both vendors concerning…
 

Top Industries

By visitors reading reviews
Computer Software Company
16%
Financial Services Firm
8%
Manufacturing Company
8%
Government
6%
Computer Software Company
15%
Financial Services Firm
10%
Manufacturing Company
9%
Government
9%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
 

Questions from the Community

What do you like most about Microsoft Defender for Office 365?
Threat Explorer is an invaluable tool for me, and it plays a crucial role in helping me discern the origins of various email campaigns, pinpointing where they emanate from, and identifying the indi...
What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
Money-wise, it is a part of the Office 365 ( /products/office-365-reviews ) suite, making it slightly more expensive compared to Trend Micro. Although Defender is free, you have to pay separately f...
What needs improvement with Microsoft Defender for Office 365?
The main area for improvement is simplifying the implementation and rollout process. There are many conditions to be met, making it challenging to ensure every system is protected. Troubleshooting ...
How does Cisco Firepower NGFW Firewall compare with Palo Alto Networks Wildfire?
The Cisco Firepower NGFW Firewall is a very powerful and very complex piece of anti-viral software. When one considers that fact, it is all the more impressive that the setup is a fairly straightf...
Which is better - Wildfire or FortiGate?
FortiGate has a lot going for it and I consider it to be the best, most user-friendly firewall out there. What I like the most about it is that it has an attractive web dashboard with very easy nav...
How does Cisco ASA Firewall compare with Palo Alto's WildFire?
When looking to change our ASA Firewall, we looked into Palo Alto’s WildFire. It works especially in preventing advanced malware and zero-day exploits with real-time intelligence. The sandbox featu...
 

Also Known As

MS Defender for Office 365
No data available
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Novamedia, Nexon Asia Pacific, Lenovo, Samsonite, IOOF, Sinogrid, SanDisk Corporation
Find out what your peers are saying about Microsoft Defender for Office 365 vs. Palo Alto Networks WildFire and other solutions. Updated: April 2025.
849,686 professionals have used our research since 2012.