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Cortex XDR by Palo Alto Networks vs Microsoft Defender for Business comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Oct 19, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
5.8
Cortex XDR offers cost-effective security with reduced infections, compliance support, enhanced efficiency, rich data, and competitive pricing.
Sentiment score
6.8
Microsoft Defender boosts productivity and security, integrating seamlessly with Office tools for significant budget savings despite ROI challenges.
They appreciate the rich telemetry data from the solution, as it provides in-depth threat identification.
Cyber Security Manager at Welab bank
Cortex XDR by Palo Alto Networks helps to reduce my total cost of ownership significantly.
Detection and Response Consultant at Inovasys
I have seen a return on investment with Cortex XDR by Palo Alto Networks, as this product is offered at a minimal cost, and we can find a good ROI from it.
Cyber Security Information Security Specialist at MHM Holding GmbH
Using Microsoft Defender for Business results in cost reductions as it consolidates various features under one product, saving around 20% to 30% of the budget.
Consultant at Dell Technologies
The value I see in Microsoft Defender for Business is in its ability to track and respond to application usage and security threats through its CASB and automation features, which are cost-beneficial.
 

Customer Service

Sentiment score
6.8
Cortex XDR support quality varies; users experience both commendable assistance and challenges, depending on region and support plans.
Sentiment score
5.5
Users have mixed reviews of Microsoft Defender's support, noting contact difficulties and inconsistent technical assistance despite good onboarding.
The technical support from Palo Alto deserves a mark of ten because they reach out within an hour whenever assistance is needed.
Head of data centers at a non-profit with 10,001+ employees
There is no back and forth, and they know what we are asking for and come up with the best resolution for a solution.
Senior Process Expert at A.P. Moller - Maersk
If any of these services are missed, it becomes a problem in terms of support tickets, follow-up, or special configuration that needs to be done in the system.
Chief of IT Architecture at a financial services firm with 10,001+ employees
It is rated ten out of ten for its quality and assistance.
Solution Consultant at BIM Group of Companies
The onboarding support is exceptional, ensuring seamless integration and implementation.
Chief Cybersecurity Architect at cytek-security
Faster support is needed for endpoint security solutions.
 

Scalability Issues

Sentiment score
7.5
Cortex XDR is scalable and cloud-based, efficiently supporting thousands of endpoints across various enterprise environments without scalability issues.
Sentiment score
8.3
Microsoft Defender for Business is scalable and effective across diverse environments, though special configurations might impact growth speed.
Cortex XDR by Palo Alto Networks can be expanded anytime by purchasing another license without any issues related to scalability.
Head of data centers at a non-profit with 10,001+ employees
The cloud-based nature of the solution ensures high scalability.
Solution Consultant at BIM Group of Companies
The scalability of Microsoft Defender for Business is rated as ten, indicating it is very scalable.
Consultant at Dell Technologies
In terms of scalability, I would rate Microsoft Defender for Business a ten.
Public Cloud Engineer at Prudential
 

Stability Issues

Sentiment score
8.1
Cortex XDR is stable and reliable, with minimal performance issues and consistent performance despite initial configuration challenges.
Sentiment score
7.2
Microsoft Defender for Business is stable and reliable, with minimal crashes, but some report occasional bugs impacting stability.
Cortex remains fast and responsive, even with increasing data and alerts.
Final Year Student at Gitam University
The thresholds we've seen on our firewall boxes at some instances reached 80% to 85%, but even at that level of utilization, we don't observe any latency or any issues reported with respect to accessing the application.
Senior Process Expert at A.P. Moller - Maersk
Cortex XDR is stable, offering high quality and reliable performance.
Cyber Security Manager at Welab bank
No customer complaints about its functionality or reliability.
Solution Consultant at BIM Group of Companies
Although it generally works, there are occasional issues and errors that sometimes require a complete system format to rectify.
I would rate the stability of Microsoft Defender for Business with a three out of ten, where one is very bad.
Public Cloud Engineer at Prudential
 

Room For Improvement

Cortex XDR needs better compatibility, UX, report customization, and pricing while reducing performance issues and enhancing automation and detection.
Microsoft Defender for Business needs better reporting, integration, simplified interface, and enhanced features to address various limitations and concerns.
Improving reporting and dashboard customization, along with the addition of real-time and exportable reports, would help SOC teams greatly.
Final Year Student at Gitam University
The inclusion of this feature would allow the application of DLP policies alongside antivirus policies via a single agent and console, making it more competitive as other OEMs often offer DLP solutions as part of their antivirus products.
Pre-Sales Architect at network techlab
If the per GB data could be provided at a certain level free of cost or at the same cost which the customer is taking for the entire bundle, that would be better.
Cyber Security Information Security Specialist at MHM Holding GmbH
Microsoft should provide batch management solutions with the application, integrating pass management with roles.
Solution Consultant at BIM Group of Companies
Features related to Advanced Persistent Threat detection vectors and cyber kill chain integrations are not available out-of-the-box.
CISO at a financial services firm with 11-50 employees
There can be improvements in the user interface to make it more intuitive.
Information Technology Security Consultant at Navaio IT Security
 

Setup Cost

Cortex XDR offers flexible licensing, ranging $55-$90 annually, deemed cost-effective despite higher setup costs, suitable for any enterprise.
Microsoft Defender for Business offers competitive pricing with enterprise value, though some users find costs high compared to competitors.
The pricing on SentinelOne is far more reasonable and cheaper than Cortex XDR by Palo Alto Networks.
Consultant at a tech services company with 1,001-5,000 employees
I would say it is definitely not a cheap product, considering how mature it is and how scalable all Palo Alto products are together.
Senior Process Expert at A.P. Moller - Maersk
Cortex XDR is perceived as expensive by some customers, yet offers dynamic pricing.
Cyber Security Manager at Welab bank
Single-year pricing remains good.
Solution Consultant at BIM Group of Companies
The pricing is quite affordable at the enterprise level with no extra expenses noted.
Consultant at Dell Technologies
Although the cost can be slightly higher, it expedites deployment, which is beneficial, especially for startups.
CISO at a financial services firm with 11-50 employees
 

Valuable Features

Cortex XDR offers advanced threat detection, AI capabilities, easy integration, remote management, and rapid response, enhancing security measures.
Microsoft Defender for Business integrates seamlessly with Microsoft products, offering comprehensive security, scalability, and user-friendly features for effective threat management.
It incorporates AI for normal behavior detection, distinguishing unusual operations.
Cyber Security Manager at Welab bank
The product provides automation responses in case of a threat attack, severity assessments, centralized manageability, and comprehensive compliance features, resulting in reduced costs.
Pre-Sales Architect at network techlab
It includes machine learning to easily analyze data and detect complex threats across endpoints, networks, or clouds.
Final Year Student at Gitam University
The threat detection capabilities are robust, with a dedicated research team and a continuously updated threat feed.
Information Technology Security Consultant at Navaio IT Security
Its vulnerability management is regarded as one of the best in the industry.
Solution Consultant at BIM Group of Companies
The most effective features of Microsoft Defender for Business include its threat detection and response capabilities in managing vulnerabilities and ransomware attacks.
Consultant at Dell Technologies
 

Categories and Ranking

Cortex XDR by Palo Alto Net...
Ranking in Endpoint Protection Platform (EPP)
5th
Average Rating
8.4
Reviews Sentiment
7.0
Number of Reviews
101
Ranking in other categories
Endpoint Detection and Response (EDR) (8th), Extended Detection and Response (XDR) (7th), Ransomware Protection (2nd), AI-Powered Cybersecurity Platforms (2nd)
Microsoft Defender for Busi...
Ranking in Endpoint Protection Platform (EPP)
16th
Average Rating
7.8
Reviews Sentiment
6.9
Number of Reviews
19
Ranking in other categories
Microsoft Security Suite (16th)
 

Mindshare comparison

As of December 2025, in the Endpoint Protection Platform (EPP) category, the mindshare of Cortex XDR by Palo Alto Networks is 3.4%, down from 4.3% compared to the previous year. The mindshare of Microsoft Defender for Business is 2.0%, up from 1.9% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Protection Platform (EPP) Market Share Distribution
ProductMarket Share (%)
Cortex XDR by Palo Alto Networks3.4%
Microsoft Defender for Business2.0%
Other94.6%
Endpoint Protection Platform (EPP)
 

Featured Reviews

ABHISHEK_SINGH - PeerSpot reviewer
Senior Process Expert at A.P. Moller - Maersk
Gained full visibility and streamlined threat detection through behavior-based insights and AI integration
Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.
Takayuki-Umehara - PeerSpot reviewer
Public Cloud Engineer at Prudential
Product deployment protects assets but needs improvement in system support
I am doing maintenance for Microsoft Defender for Business, and I'm currently working with it. We don't need to use the latest version of Microsoft Defender for Business. We still use the latest virus definition file that Microsoft Defender for Business has automatically updated. We implement a basic update mechanism. Our compliance division manages how many servers and PCs we have and whether those servers have antivirus solutions. I am not certain about how Microsoft Defender for Business helps with AI-driven security strategies. I just use it normally and don't know if it uses AI technology. I rate Microsoft Defender for Business a six out of ten.
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Top Industries

By visitors reading reviews
Computer Software Company
12%
Financial Services Firm
10%
Manufacturing Company
8%
Comms Service Provider
6%
Computer Software Company
18%
Comms Service Provider
8%
Government
6%
Financial Services Firm
6%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business43
Midsize Enterprise18
Large Enterprise43
By reviewers
Company SizeCount
Small Business15
Midsize Enterprise2
Large Enterprise3
 

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One
Cortex XDR by Palo Alto vs. SentinelOne SentinelOne offers very detailed specifics with regard to risks or attacks. The ability to reverse damage caused by ransomware with minimal interruptions to...
Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)
Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions that are very scalable, secure, and user-friendly. Cortex XDR by Palo Alto offers ...
How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface, applies behavioral-based endpoint protection and response, and includes risk-ba...
What do you like most about Microsoft Defender for Business?
A few things are valuable. One is the alerting we see when any kind of intrusion is happening, any kind of malware is being deployed across the endpoints, or any kind of suspicious activity is goin...
What is your experience regarding pricing and costs for Microsoft Defender for Business?
Our thoughts on the pricing for Microsoft Defender for Business are that we wish it could be better. If the pricing was a little better, we would definitely increase what we currently have.
What needs improvement with Microsoft Defender for Business?
Microsoft Defender for Business could be improved by making the advanced threat hunting available to all plans, as currently, it is only available to one of their plans which is not encouraging. It...
 

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps
No data available
 

Overview

 

Sample Customers

CBI Health Group, University Honda, VakifBank
Information Not Available
Find out what your peers are saying about Cortex XDR by Palo Alto Networks vs. Microsoft Defender for Business and other solutions. Updated: December 2025.
879,259 professionals have used our research since 2012.