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ThreatLocker Zero Trust Endpoint Protection Platform vs Trend Micro Smart Protection comparison

 

Comparison Buyer's Guide

Executive SummaryUpdated on Oct 5, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

ROI

Sentiment score
7.9
ThreatLocker Zero Trust boosts ROI by blocking threats, reducing risks, and enhancing security with seamless integration and quick adaptation.
Sentiment score
4.8
Trend Micro Smart Protection delivers positive ROI, preventing breaches, updating systems, and supporting financial and reputational benefits over time.
If something were to happen without ThreatLocker, the cost would be huge, and thus, having it is definitely worth it.
Tier 1 IT Engineer at a retailer with 11-50 employees
The main return on investment is peace of mind, knowing that with ThreatLocker on any endpoint, it will almost always block all malicious code or exploits, even zero-day exploits.
Project Engineer at Lutz M&A, LLC
It keeps malware, Trojans, and ransomware at bay.
Technical Engineer at Cloud 1 Solutions
 

Customer Service

Sentiment score
7.7
ThreatLocker offers exceptional 24/7 customer service with fast issue resolution, highly rated by users for speed and expertise.
Sentiment score
5.1
Trend Micro Smart Protection's customer service varies; premium is effective, but standard support often faces delays and availability issues.
They have been very responsive, helpful, and knowledgeable.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate their customer support a ten out of ten.
Director, Managed Services at a consultancy with 11-50 employees
Their support is world-class.
Supervisor, Client Security at a consultancy with 11-50 employees
The agent is very light, and it doesn't cause any issues on the machine.
Solutions Architect at a tech services company with 51-200 employees
 

Scalability Issues

Sentiment score
8.0
ThreatLocker scales efficiently, handling thousands of endpoints easily, with updates and flexible deployment supporting diverse organizational needs.
Sentiment score
8.0
Trend Micro Smart Protection scales effectively for businesses of all sizes with positive feedback on performance and flexibility.
I started off with just the servers, and within a month and a half, I set up the entire company with ThreatLocker.
Technical Engineer at Cloud 1 Solutions
It seems to primarily operate on the endpoints rather than at a central location pushing out policies.
Systems Security Analyst & Deputy Security Officer at a financial services firm with 201-500 employees
I would rate it a ten out of ten for scalability.
Project Engineer at Lutz M&A, LLC
 

Stability Issues

Sentiment score
7.4
ThreatLocker Zero Trust Platform offers stable performance, minimal downtime, quick issue resolution, and seamless integration with operating systems.
Sentiment score
7.7
Trend Micro Smart Protection is stable, reliable, and well-rated, though improved compatibility with major vendors could enhance user experience.
For five years, we have not had a problem.
Supervisor, Client Security at a consultancy with 11-50 employees
Once deployed, it downloads the policies locally, so even if the computer doesn't have internet, it doesn't matter.
Information Cybersecurity Technology Specialist at Freez.it
It has been very stable, reliable, and accessible.
COO at Panda Technology
 

Room For Improvement

ThreatLocker could improve by enhancing training, UI, reporting, integration, and support to address approval and update challenges.
Trend Micro Smart Protection needs enhancements in management tools, AI, compatibility, support, pricing, integration, and threat detection features.
Controlling the cloud environment, not just endpoints, is crucial.
COO at Panda Technology
This is problematic when immediate attention is needed.
Senior System Administrator at Molders Group Limited
Comprehensive 24-hour log monitoring is a valuable enhancement for both business and enterprise-level users.
IMS ENGINEER at a tech vendor with 1,001-5,000 employees
We've experienced compatibility issues with Windows endpoint protection.
Security Architect at Kyndryl
 

Setup Cost

ThreatLocker offers a cost-effective Zero Trust solution with flexible pricing, appreciated for transparency and easy setup across clients.
Trend Micro Smart Protection pricing varies widely, seen as competitive yet sometimes more expensive, with extensive licensing terms.
After conversations with other partners, it became clear we underpriced it initially, which caused most of our issues.
Director, Managed Services at a consultancy with 11-50 employees
We are moving towards the Unified solution, where they basically bundle everything together, providing us better stability with the ability to bring in new product offerings without having to go back to the customer and say, 'This is going to cost you.'
Supervisor, Client Security at a consultancy with 11-50 employees
I had a really good deal at the time, and it continues to be cost-effective.
Cyber Security Specialist at Bremmar Consulting
However, their pricing is comparable to CrowdStrike.
Security Architect at Kyndryl
 

Valuable Features

ThreatLocker enhances security and reduces costs with application control, instant support, intuitive interface, and comprehensive training resources.
Trend Micro Smart Protection delivers comprehensive security with robust features, low resource usage, scalability, and seamless IT system integration.
ThreatLocker Zero Trust Endpoint Protection Platform's ability to block access to unauthorized applications has been excellent.
Cyber Security Specialist at Bremmar Consulting
It protects our customers.
CTO at Zettabytes
The major benefit is fewer breaches overall, as nothing can be run without prior approval. This helps my company protect its data and secure itself effectively.
Tier 1 IT Engineer at a retailer with 11-50 employees
The most effective features of Trend Micro Smart Protection are its antivirus and malware capabilities.
Security Architect at Kyndryl
 

Categories and Ranking

ThreatLocker Zero Trust End...
Ranking in Endpoint Protection Platform (EPP)
6th
Average Rating
9.2
Reviews Sentiment
7.4
Number of Reviews
40
Ranking in other categories
Network Access Control (NAC) (4th), Advanced Threat Protection (ATP) (6th), Application Control (1st), ZTNA (4th), Ransomware Protection (1st)
Trend Micro Smart Protection
Ranking in Endpoint Protection Platform (EPP)
33rd
Average Rating
8.0
Reviews Sentiment
7.0
Number of Reviews
44
Ranking in other categories
No ranking in other categories
 

Mindshare comparison

As of January 2026, in the Endpoint Protection Platform (EPP) category, the mindshare of ThreatLocker Zero Trust Endpoint Protection Platform is 1.1%, up from 0.7% compared to the previous year. The mindshare of Trend Micro Smart Protection is 0.9%, up from 0.5% compared to the previous year. It is calculated based on PeerSpot user engagement data.
Endpoint Protection Platform (EPP) Market Share Distribution
ProductMarket Share (%)
ThreatLocker Zero Trust Endpoint Protection Platform1.1%
Trend Micro Smart Protection0.9%
Other98.0%
Endpoint Protection Platform (EPP)
 

Featured Reviews

CL
Supervisor, Client Security at a consultancy with 11-50 employees
World-class support and highly effective for application control and elevation
Their product is solid. I have a hard time complaining much about it because when we do find little things, they are usually interface-related or related to things that would be nice to have. Their idea portal, unlike so many other vendors we deal with, shows movement. At least four to eight features of ThreatLocker exist because I made a request in the last five years, and it became a feature of the actual product. When it comes to improvements, we moved the product as customers, and we got to move the product by making suggestions. They seem to be very reactive to it, so there is not a whole lot that they actively need to change right now. It is one of those situations where when we run into something that would be nice to have, it happens. They make it work.
DL
Security Architect at Kyndryl
Antivirus and malware capabilities effectively enhance threat prevention and integration
Our primary use case for Trend Micro Smart Protection is endpoint protection The most effective features of Trend Micro Smart Protection are its antivirus and malware capabilities.  Additionally, it integrates well with all our tools, including ServiceNow, for fault reporting. This integration…
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Top Industries

By visitors reading reviews
Computer Software Company
25%
Retailer
8%
Manufacturing Company
8%
Financial Services Firm
7%
Manufacturing Company
13%
Performing Arts
11%
Computer Software Company
9%
Healthcare Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business32
Midsize Enterprise4
Large Enterprise3
By reviewers
Company SizeCount
Small Business16
Midsize Enterprise14
Large Enterprise16
 

Questions from the Community

What do you like most about ThreatLocker Allowlisting?
The interface is clean and well-organized, making it simple to navigate and find what we need.
What is your experience regarding pricing and costs for ThreatLocker Allowlisting?
Pricing, setup costs, and licensing have been pretty accessible and manageable. It was not too expensive to get started, especially at a small scale for a smaller MSP. It is very accessible, easy t...
What needs improvement with ThreatLocker Allowlisting?
Going with the theme of ThreatLocker Zero Trust Endpoint Protection Platform being a one-stop shop where they have just about everything, and they have a really good product stack as is. However, t...
What do you like most about Trend Micro Smart Protection?
The tool offers centralized security management. The tool's deployment is flexible.
What is your experience regarding pricing and costs for Trend Micro Smart Protection?
I find that Trend Micro Smart Protection is affordable; I don't think it can be quite expensive.
What needs improvement with Trend Micro Smart Protection?
Technical support needs to be improved. We had a customer move from Trend Micro because they didn't the support. Both response time and ownership are the problems with support. Trend Micro Smart Pr...
 

Also Known As

Protect, Allowlisting, Network Control, Ringfencing
Trend Micro Smart Protection Complete
 

Overview

 

Sample Customers

Information Not Available
Atma Jaya Catholic University of Indonesia, Blekinge County Council, Bulgarian American Credit Bank, Cancer Research UK, Delacour, Evalueserve, Gulftainer, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Mazda Motor Logistics Europe, MEDHOST, Nikigolf, Ochsner Health System, SIAX Computing Solutions, Tegen
Find out what your peers are saying about ThreatLocker Zero Trust Endpoint Protection Platform vs. Trend Micro Smart Protection and other solutions. Updated: December 2025.
879,422 professionals have used our research since 2012.