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Cisco SecureX [EOL] vs Microsoft Defender XDR comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Nov 2, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cortex XDR by Palo Alto Net...
Sponsored
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
112
Ranking in other categories
Endpoint Protection Platform (EPP) (4th), Endpoint Detection and Response (EDR) (6th), Extended Detection and Response (XDR) (4th), Ransomware Protection (2nd), AI-Powered Cybersecurity Platforms (1st)
Cisco SecureX [EOL]
Average Rating
9.0
Reviews Sentiment
8.2
Number of Reviews
13
Ranking in other categories
No ranking in other categories
Microsoft Defender XDR
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
108
Ranking in other categories
Endpoint Detection and Response (EDR) (8th), Extended Detection and Response (XDR) (5th), Microsoft Security Suite (4th)
 

Featured Reviews

ABHISHEK_SINGH - PeerSpot reviewer
Senior Process Expert at A.P. Moller - Maersk
Gained full visibility and streamlined threat detection through behavior-based insights and AI integration
Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.
Alon K - PeerSpot reviewer
CTO & VP of Cyber Solutions, Israel at Rockwell Automation
Gives our customers visibility and they don't have to go multiple management consoles anymore
One of the examples is related to forensics. The forensics are amazing because when you have enrichment, and the solutions talk with each other, when you need it, you have the ability to know everything in the organization: when, why, whatever. With just one click you have information from email, from the endpoint, from the web. Let's say that tomorrow morning, you have a ransom[ware] attack in your organization and you would like to know from which email it came, or where the customer saved the file, even though the incident didn't occur at the same moment. With SecureX, you have Cisco Threat Response inside. [With] one click, you get all of the flow. That's amazing value. That also releases resources for our customers. The customers don't have to connect many systems and try to register the event on each system, or to go to the SIEM and do a correlation. That's the one-stop shop for the customers, and that's amazing.
reviewer2812758 - PeerSpot reviewer
Infosec at a government with 10,001+ employees
Integrated defenses have unified threat hunting, phishing simulations, and identity investigations
I appreciate Microsoft Defender XDR's MDE, Microsoft Defender tool, which has Attack Simulator. Instead of doing a phishing campaign and getting a separate tool, Microsoft Defender XDR does it all. These features of Microsoft Defender XDR have helped us conduct a phishing campaign quarterly, which has been beneficial. I also appreciate the fact that it has Defender for Office integrated, Defender for Identity, and everything integrated together. I would describe the process of using Microsoft Defender XDR to prioritize incidents in my security operations as quite decent. I appreciate the automatic alerting system where any incidents or alerts we receive come directly to our email. From there, we can open the email, go directly to Microsoft Defender XDR, and start our investigations and remediations. I perceive the integration of security and identity access management in Microsoft Defender XDR as affecting my identity protection strategies very well because it is well integrated with Purview, integrated well with Entra ID, and integrated well with Exchange. I especially appreciate MDO, the Office product. If anything happens and I want to conduct an investigation, it takes me directly to Exchange, where I can also investigate any emails or phishing incidents. Instead of going to different portals, everything can be done from Microsoft Defender XDR. If necessary for further investigation, Microsoft Defender XDR then directs me to that environment. I would assess the integration of AI in guiding security actions within Microsoft Defender XDR as quite positive. Recently, Security Copilot went big, and it is beneficial that I can use that, especially to write KQL. I can do threat hunting features and intelligence all within using Microsoft's Security Copilot. It also has a nice AI feature for threat hunting. I know that all the Defender logs go to Sentinel, and I can pull it up from Microsoft Defender XDR or from Sentinel. The fact that I can actually do all that within Microsoft Defender XDR is a nice feature. In the top module, I can do threat lookups, and I can actually type KQLs in Microsoft Defender XDR and look up incidents. Predictive shielding has had a nice impact on my proactive security measures. It is beneficial that it has, similar to Entra ID, a secure score. For me to improve the product, the secure score helps me out. If I rate it from highest to lowest, I can see what things I can improve. Secure score helps me see what areas I can improve in Microsoft Defender XDR to increase my score and bring it to 80 or more. Knowing Microsoft Defender XDR from using it since 2019, before COVID days, I know that they have improved significantly. It is much more user-friendly and has a very nice vulnerability feature that I find handy and useful. The fact that this feature integrates into Intune is also very decent.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"Cortex XDR by Palo Alto Networks's ability to block sophisticated threats in real time is quite good and is on par with SentinelOne's."
"The information the dashboard provides is very clear."
"We use Cortex XDR by Palo Alto Networks for its ability to detect based on behavior rather than simple virus scan to prevent malicious activities."
"It has a higher cost than other solutions, like CrowdStrike or Microsoft’s EDR tools, but it reduces the cost of our operations because it’s a new generation antivirus tool."
"Cortex XDR by Palo Alto Networks saves time in various ways, although the user interface is fairly standard."
"The most valuable for us is the correlation feature."
"There are a lot of lead solutions in this space, however, Palo Alto is number one."
"The normal protection was really effective, and we detected situations that if we didn't have Cortex XDR by Palo Alto Networks, it's highly likely that we would have been affected, but it protected the infrastructure."
"Using SecureX, a tool provided by Cisco, we can easily integrate it with many of our other Cisco products such as Cisco ISE and many networking devices."
"Using SecureX, we can aggregate the data from all our security products, automate many of our tasks that we had to do manually before, save a huge amount of time, and provide many reports about usage of our systems and networks to our leaders and managers to show what we can do to make our security better."
"We've reduced our workload by 20 to 30 percent just from being able to focus on the important things, as this product really does a lot of the grunt work for you."
"Our customers find the product's third-party integrations valuable. Our customers are also impressed with the tool's capability to pick up third-party threat feeds and use that as part of the decision-making process."
"I like that I don't have to jump around to five different products and log into five different places to view the data that it returns."
"It is one of my favorite things that has ever been built."
"The most valuable feature is its ability to manage all the applications and visibility. For example, if there is malware, spam, or another component that wants to attack the company in my servers, network, or applications, then SecureX will react to the problem."
"SecureX takes all the separate pieces of security within your company, adds in intelligence from different sites and services on the internet, and makes them work together."
"The threat intelligence is excellent."
"Microsoft 365 Defender is a good solution and easy to use."
"The support provides a 24 hrs service which I am completely satisfied with."
"The ability to integrate and observe a more cohesive narrative across the products is crucial."
"I like that it's fully integrated with Windows, Microsoft 365 Exchange Online, and Outlook. It is better than other antivirus solutions because it's fully integrated with all Microsoft products. It's easy to integrate them and onboard all Windows devices from SCCM."
"For me, the advanced hunting capabilities have been really great. It allowed querying the dataset with their own language, which is KQL or Kusto Query Language. That has allowed me to get much more insight into the events that have occurred. The whole power of 365 Defender is that you can get the whole story. It allows you to query an email-based activity and then correlate it with an endpoint-based activity."
"Within advanced threat hunting, the tables that have already been defined by Microsoft are helpful. In the advanced threat hunting tab, there were different tables, and one of the tables was related to device info, device alert, and device events. That was very helpful. Another feature that I liked but didn't have access to was deep analysis."
"The attack simulation is excellent; initially, this feature wasn't very robust, but Microsoft improved what we could achieve with it. We can now customize our practice phishing emails and include our company logo, for example. Attack simulation also helps integrate with third-party solutions where applicable and provides an overview of our security architecture through testing. The summary includes areas for improvement in our protection and what steps we need to take to get there."
 

Cons

"Data privacy is a matter of concern. You have to be careful with data privacy, it can be sensitive and Cortex can have most of your access."
"Cortex XDR by Palo Alto Networks could improve its user interface, which is more complicated compared to competitors such as SentinelOne."
"I don't like that they have different types of licenses. For example, if users select a license, they think they will have all the platforms they need to improve their network or security. But after some time, Palo Alto Networks changed their licensing, and some of the features that, for example, were free at the beginning now have a cost. I think the integration can be improved. For example, a lot of tools are just integrated through APIs."
"I have seen lagging with Cortex XDR by Palo Alto Networks. There was one time when we faced a threat actor trying to gain access to our system. When our team utilized the tool, we were all on the same dashboard and we faced a lag issue at that time of around five minutes, which was quite significant."
"It's more focused on network communication. If a customer wants to increase the level of protection and start working with documents, it's impossible to integrate these features into the system. It's more of a communication-oriented system than a content security-oriented system."
"The GUI could be improved."
"Although I would say this product is highly-rated, it could probably do more because nothing does everything that you want."
"I have run into some detection issues with Cortex XDR. It needs to be better at detection of internal attacks."
"Enhancing automation capabilities could further improve the product."
"I'm not sure that I would call it a bug, but sometimes the solution is a little slow."
"The automation and orchestration could be simpler."
"Remediation stuff could be integrated into the product's automation."
"I would like it to integrate with another solution, e.g., DNA. I would like it to connect to that solution, but not the security aspect."
"It would be nice if they had a different pricing model. Most of our budget for projects goes towards Cisco."
"The automation and orchestration could be simpler. It could be that all the other parts are that easy to use so that these stick out as a negative, but that's the trickiest part for us. The workflows within the orchestration are just a bit more difficult."
"The documentation can be improved and the on-prem integration. The set of applications that it was integrated with wasn't comprehensive."
"Correctly updated records are the most significant area for improvement. There have been times when we were notified of a required fix; we would carry out the fix and confirm it but still get the same notification a week later. This seems to be a delay in records being updated and leads to false reporting, which is something that needs to be fixed."
"I would like more of the features in Defender for 365 to be included in the smaller licenses. Even if I buy a small license and don't need everything, security shouldn't be a question. Security is one of the main aspects of all projects from our side, so it would be nice to have more features in the smaller licenses."
"Microsoft could improve on threat hunting and build more on threat detection and handling. The cybersecurity and cloud security posture features are a bit lesser than standard security products."
"The abundance of sub-dashboards and sub-areas within the main dashboard can be confusing, even if it all technically makes sense."
"The web filtering solution needs to be improved because currently, it is very simple."
"In the beginning, it's difficult to navigate the system because it is quite large. Just trying to find your way and understand how the system works can be hard. After spending quite a lot of time searching it's a lot easier, but I wish it were a bit more user-friendly when you're trying to find things."
"The licensing is a nightmare and has room for improvement."
"The mobile app support for Android and iOS is difficult and needs improvement."
 

Pricing and Cost Advice

"It has reasonable pricing for the use cases it provides to the company."
"When we first bought it, it was a bit expensive, but it was worth it. The licensing was straightforward."
"The price of the solution is high for the license and in general."
"I feel it is fairly priced."
"It's the most expensive solution, but features-wise, it's quite strong. It's very good for protection, so the results are very good in the case of protection. I would rate it a two out of ten in terms of pricing."
"In terms of the cost Cortex XDR by Palo Alto Networks is very expensive because we are a Mexican company and when you translate dollars to pesos the cost is very high. The solution is very expensive for Mexican companies. I understand that they have international prices, but I do not think it offsets the price enough for many companies in countries, such as Mexico. The amount it is reduced is not a massive percentage."
"Its pricing is kind of in line with its competitors and everybody else out there."
"Licensing for Palo Alto Networks Cortex XDR can be costly, especially when it comes to a hundred users. A license is required for each user, and the subscription must be renewed on a yearly basis."
"For the value you get, the pricing of the solution is excellent."
"It is free. It can't get any better than that."
"Cisco SecureX is more expensive than Trend Micro. However, considering the integration capabilities with other solutions and the quality of technical support, I believe there's justification for the price difference."
"You can spend less money for another solution, but if you really want to have a good solution you have to pay. We are happy that we are getting such a good solution for what we are spending."
"The pricing is the best part of this solution. It is free if you buy Umbrella or Duo Security. It is also a good solution."
"The pricing is competitive, especially for education institutions. Licensing can be a little bit difficult to navigate, especially with resellers with Cisco, but for us it has been pretty easy."
"The product is absolutely free to any customer. As such, the only thing one must keep in mind is that as long as he already has one Cisco security product, irregardless of what that product is, SecureX is available for free."
"It comes free with all Cisco products. So, it is a good price."
"The solution is affordable, and we haven't been hit with any hidden costs. The subscription model is straightforward, and it's easy to understand how much additional features cost. If we need to cancel a license or feature, we do that well in advance to avoid being charged for it, but overall, the pricing and licensing are simple and easy."
"The licensing fee for Microsoft 365 Defender is fair."
"It can be complex to navigate since customers have varying licensing agreements across Microsoft. If they go straightforward with E5 for all users, it's simple, but combinations based on budget constraints can complicate things."
"It is fairly priced because we get complete integrated services with the E5 license."
"All I can say again is the E5 gives you all the capabilities that it offers. It also gives Office 365 and one terabyte of storage. All in all, the E5 license model makes sense. There are some people who say it's quite costly, but rather than paying different vendors, it makes sense to go all in with Microsoft if you've got that licensing. From that perspective, it's cost-effective, but I can't comment much on that."
"They have moved from a licensing model to pay-per-use... The question is: What happens if, for any reason, there's not enough budget to accept this model? That could be a great problem."
"The most valuable licensing option is expensive, so pricing could be improved. Licensing options for this solution also need to be consolidated, because they frequently change."
"I believe the pricing is fair and acceptable. I consider it to be reasonable and satisfactory."
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Top Industries

By visitors reading reviews
Construction Company
12%
Financial Services Firm
11%
Manufacturing Company
10%
Comms Service Provider
9%
Construction Company
14%
Outsourcing Company
10%
Marketing Services Firm
9%
Computer Software Company
8%
Computer Software Company
9%
Financial Services Firm
9%
Comms Service Provider
7%
Manufacturing Company
7%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business46
Midsize Enterprise20
Large Enterprise52
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise7
Large Enterprise3
By reviewers
Company SizeCount
Small Business46
Midsize Enterprise28
Large Enterprise41
 

Questions from the Community

Cortex XDR by Palo Alto vs. Sentinel One
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Comparing CrowdStrike Falcon to Cortex XDR (Palo Alto)
Cortex XDR by Palo Alto vs. CrowdStrike Falcon Both Cortex XDR and Crowd Strike Falcon offer cloud-based solutions th...
How is Cortex XDR compared with Microsoft Defender?
Microsoft Defender for Endpoint is a cloud-delivered endpoint security solution. The tool reduces the attack surface,...
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What is your experience regarding pricing and costs for Microsoft 365 Defender?
My experience with the pricing, setup costs, and licensing of Microsoft Defender XDR is that we are on an E5 license,...
What needs improvement with Microsoft 365 Defender?
From my perspective, Microsoft Defender XDR can be improved with better visibility in certain areas where I can trigg...
What is your primary use case for Microsoft 365 Defender?
My main use cases for Microsoft Defender XDR are telemetry, advanced hunting, and the ability to perform host isolati...
 

Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps
Kenna.AppSec, Kenna.VI
Microsoft 365 Defender, Microsoft Threat Protection, MS 365 Defender
 

Overview

 

Sample Customers

CBI Health Group, University Honda, VakifBank
NHS, Rackspace, UNC Pembroke, University of North Carolina at Charlotte, Missing Piece
Accenture, Deloitte, ExxonMobil, General Electric, IBM, Johnson & Johnson and many others.
Find out what your peers are saying about CrowdStrike, SentinelOne, TrendAI and others in Extended Detection and Response (XDR). Updated: June 2026.
900,747 professionals have used our research since 2012.