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Cisco SecureX [EOL] vs Microsoft Defender XDR comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Nov 2, 2025

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Cortex XDR by Palo Alto Net...
Sponsored
Average Rating
8.4
Reviews Sentiment
6.7
Number of Reviews
118
Ranking in other categories
Endpoint Protection Platform (EPP) (4th), Endpoint Detection and Response (EDR) (5th), Extended Detection and Response (XDR) (4th), Ransomware Protection (2nd), AI-Powered Cybersecurity Platforms (1st)
Cisco SecureX [EOL]
Average Rating
9.0
Reviews Sentiment
8.2
Number of Reviews
13
Ranking in other categories
No ranking in other categories
Microsoft Defender XDR
Average Rating
8.4
Reviews Sentiment
7.1
Number of Reviews
108
Ranking in other categories
Endpoint Detection and Response (EDR) (9th), Extended Detection and Response (XDR) (5th), Microsoft Security Suite (4th)
 

Featured Reviews

ABHISHEK_SINGH - PeerSpot reviewer
Senior Process Expert at A.P. Moller - Maersk
Gained full visibility and streamlined threat detection through behavior-based insights and AI integration
Initially, we got to have a lot of false positives when we onboarded, but nowadays it's quite smooth. We have fine-tuned our security policies and allowed different levels of policies to get rid of those false positives. Currently, we are getting a fairly good amount of incidents that are not false positives or benign, but actionable items. The process is streamlined. In the initial days, the operations used to get involved in a lot of benign and other activities, but now the process is streamlined. We are leveraging the auto-detection and remediation plans. The operations teams are now more involved in other business roles as well, not just looking into the logs and fetching out what's happening there. They have fixed a lot of things. Initially, they didn't have IAC code drift detection, cloud posture management, or security posture management, but they have those now. They purchased different vendors and did a merger with that. They have now Prisma Cloud that gets integrated and now they are working with Cortex Cloud. Everything that was negative has now been addressed, and the product altogether looks to be in a very better and mature shape now. Currently, it's more or less detecting the workloads with AI-based best practices. Since most organizations are consuming AI agents and other things, we are looking forward to seeing what other feature enhancements Palo Alto can support in that.
Dene Lewis - PeerSpot reviewer
Head of Technical Strategy and Direction CAE Technology Services Ltd at CAE Technology Services Limited
A scalable SaaS based platform that helps with cyber threat intelligence and automated hunting
I would rate Cisco SecureX a ten out of ten. I find the product to be a fantastic platform. If you are eligible, start using it straight away. The best way to evaluate it is to start using it and see where it fits within your organization. I think it helps our customers really deliver their SecOps goals, and I see it as a core foundation of CAE's own security strategy going forward. Our partnership with Cisco is one that was built on trust over a long period of time. This has enabled us to work together to be able to provide the solutions that our customers need to drive their organizations forward. The value we add as a reseller is being able to work closer with our customers, understand them, and get intimate with their organizations. That enables us to offer them the right solutions that will help them achieve their goals.
reviewer2812758 - PeerSpot reviewer
Infosec at a government with 10,001+ employees
Integrated defenses have unified threat hunting, phishing simulations, and identity investigations
I appreciate Microsoft Defender XDR's MDE, Microsoft Defender tool, which has Attack Simulator. Instead of doing a phishing campaign and getting a separate tool, Microsoft Defender XDR does it all. These features of Microsoft Defender XDR have helped us conduct a phishing campaign quarterly, which has been beneficial. I also appreciate the fact that it has Defender for Office integrated, Defender for Identity, and everything integrated together. I would describe the process of using Microsoft Defender XDR to prioritize incidents in my security operations as quite decent. I appreciate the automatic alerting system where any incidents or alerts we receive come directly to our email. From there, we can open the email, go directly to Microsoft Defender XDR, and start our investigations and remediations. I perceive the integration of security and identity access management in Microsoft Defender XDR as affecting my identity protection strategies very well because it is well integrated with Purview, integrated well with Entra ID, and integrated well with Exchange. I especially appreciate MDO, the Office product. If anything happens and I want to conduct an investigation, it takes me directly to Exchange, where I can also investigate any emails or phishing incidents. Instead of going to different portals, everything can be done from Microsoft Defender XDR. If necessary for further investigation, Microsoft Defender XDR then directs me to that environment. I would assess the integration of AI in guiding security actions within Microsoft Defender XDR as quite positive. Recently, Security Copilot went big, and it is beneficial that I can use that, especially to write KQL. I can do threat hunting features and intelligence all within using Microsoft's Security Copilot. It also has a nice AI feature for threat hunting. I know that all the Defender logs go to Sentinel, and I can pull it up from Microsoft Defender XDR or from Sentinel. The fact that I can actually do all that within Microsoft Defender XDR is a nice feature. In the top module, I can do threat lookups, and I can actually type KQLs in Microsoft Defender XDR and look up incidents. Predictive shielding has had a nice impact on my proactive security measures. It is beneficial that it has, similar to Entra ID, a secure score. For me to improve the product, the secure score helps me out. If I rate it from highest to lowest, I can see what things I can improve. Secure score helps me see what areas I can improve in Microsoft Defender XDR to increase my score and bring it to 80 or more. Knowing Microsoft Defender XDR from using it since 2019, before COVID days, I know that they have improved significantly. It is much more user-friendly and has a very nice vulnerability feature that I find handy and useful. The fact that this feature integrates into Intune is also very decent.

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"The product's initial setup phase is very easy."
"Overall, it's a great platform; it integrates very well with other solutions from Palo Alto and also with our vendors, the ease of use is excellent, I love the root cause analysis from Cortex, which is amazing, and in a few clicks you can have the full root cause."
"Cortex XDR by Palo Alto Networks should be a stable solution."
"Cortex XDR by Palo Alto Networks has helped lighten the load of our security analysts because it was the major tool that we were using and the one we utilized most."
"It can automatically correlate events and logs, which is very helpful for an IT administrator. It can correlate different kinds of malware activities over a network, agent, or host system. You do not need to do it manually. It is a good feature. It is also a user-friendly solution. We have deployed it on the cloud because our space does not provide any flexibility for on-premises deployment, but Palo Alto has added some flexibility to install it on-premises. It must be like the same Cortex XDR agent for all the VPN services, web filtering services, and everything else."
"It has a higher cost than other solutions, like CrowdStrike or Microsoft’s EDR tools, but it reduces the cost of our operations because it’s a new generation antivirus tool."
"There has been a significant reduction of approximately 70% to 80% in our internal MTTR and MTTD metrics, now around five to eight minutes whereas previously it was hours, which has helped tremendously."
"The most valuable features are incident creation, policy-based protection, IP whitelisting, and device encryption. These are beneficial for endpoint and server security."
"If management wants to ingest reports at a high level from all of the different products, they would only need one login to SecureX to view this information as opposed to separate logins for each of the integrated products."
"It is one of my favorite things that has ever been built."
"The automation and orchestration tools are the most valuable features."
"SecureX definitely provides us with contextual awareness throughout our security ecosystem, since it allows us to integrate multiple threat intelligence feeds, as well as multiple security appliances and platforms."
"SecureX has been keeping our devices safe during the pandemic and we haven't had any major threats that have come in or that have been found on our devices."
"Using SecureX, we can aggregate the data from all our security products, automate many of our tasks that we had to do manually before, save a huge amount of time, and provide many reports about usage of our systems and networks to our leaders and managers to show what we can do to make our security better."
"The most beneficial feature of Cisco SecureX for cybersecurity efforts is its integration with other Cisco solutions and the environment. This sets it apart, as its APIs and overall integration capabilities are very strong. Additionally, its detection capabilities are commendable."
"The most valuable feature is its ability to manage all the applications and visibility. For example, if there is malware, spam, or another component that wants to attack the company in my servers, network, or applications, then SecureX will react to the problem."
"The most valuable feature is probably the aggregation and correlation of the different telemetry points with Defender for Identity, Defender for Endpoint, and Defender for Cloud Apps. All of these various things are part of that portal. We've wanted that single pane of glass for years."
"365 Defender saves us a lot of money because we don't have to recover data or hire outside lawyers to help us with legal trouble."
"Microsoft Defender XDR's capability to automatically disrupt advanced cyber attacks is very effective."
"Defender XDR has a feature called the timeline that lets you track all activities. It helps a lot with investigations."
"Overall, the solution has decreased our time to detect and respond."
"It provides a single pane of glass within the 365 admin interface, streamlining our experience by consolidating information in one place and eliminating the need to navigate through multiple interfaces."
"The proactive remediation aspects and the surfacing of suspicious activity for investigation and escalation are the key aspects we appreciate most."
"The incident-level visibility across the cyber attack chain when using Microsoft Defender XDR is great."
 

Cons

"In some cases, there are too many options for me, and it is a bit too hard to find some settings which I really need to implement."
"We had a problem with getting our older endpoints up to date, but their newest updates have been really good. I've been pleased with it in terms of what our needs are. It's doing what we want it to do."
"I would like to see improvement in the tool's user interface, particularly in the area of managing alerts and providing more reporting capabilities."
"The negative aspect I see is the economic model used by Palo Alto."
"The solution should force customers to integrate with network traffic to see the full benefits of XDR."
"There are some limitations on the Traps agents."
"I don't like that they have different types of licenses. For example, if users select a license, they think they will have all the platforms they need to improve their network or security. But after some time, Palo Alto Networks changed their licensing, and some of the features that, for example, were free at the beginning now have a cost. I think the integration can be improved. For example, a lot of tools are just integrated through APIs."
"Currently, if you use Palo Alto endpoint protection as the only solution it's very complicated to remove pre-existing threats."
"I would like it to integrate with another solution, e.g., DNA. I would like it to connect to that solution, but not the security aspect."
"They could expand into more areas."
"Remediation stuff could be integrated into the product's automation."
"For us, the biggest sticking point is that the product is not being designed for multi-tenancy use at present, from an MSP perspective."
"I'm not sure that I would call it a bug, but sometimes the solution is a little slow."
"It is good that it provides information. However, I think that there needs to be more actionable items for us based on the information provided."
"The front-end work controls the new algorithm and the firewall rules. The search feature of these rules could be improved."
"The automation and orchestration could be simpler."
"The advanced threat-hunting capabilities are phenomenal, and the security copilot enhances that, but some data elements could be better or have more context inside of the advanced tables themselves. The schemas feel a little limited to what they're building into the product. It's probably just a maturity thing. I imagine we'll see the features I want in the next year."
"The licensing process needs improvement and clarification, as it is currently difficult to understand which features are licensed to which users."
"Intrusion detection and prevention would be great to have with 365 Defender."
"The onboarding and offboarding need improvement."
"Just like in any solution, the price can always be cheaper."
"The licensing is a nightmare and has room for improvement."
"The data recovery and backup could be improved."
"The Defender agent itself is more compatible with Windows 10 and Windows 11. Other than these two lines, there are so many compatibility issues. Security is not only about Microsoft. The core technical aspects of it are quite good, but it would be good if they can better support non-Microsoft solutions in terms of putting the agents directly into VMware and other virtualization solutions. There should be more emphasis on RHEL and other operating systems that we use, other than Windows, in the server category."
 

Pricing and Cost Advice

"When we first bought it, it was a bit expensive, but it was worth it. The licensing was straightforward."
"The pricing is okay, although direct support can be expensive."
"I don't like that they have different types of licenses."
"The cost depends on your chosen license type, like Pro or other licenses."
"The pricing seems fair, and I do like the licensing model. You use wherever they are, and it is elastic."
"The pricing is a little high. It is per user per year."
"It's the most expensive solution, but features-wise, it's quite strong. It's very good for protection, so the results are very good in the case of protection. I would rate it a two out of ten in terms of pricing."
"This is an expensive solution."
"Cisco SecureX is more expensive than Trend Micro. However, considering the integration capabilities with other solutions and the quality of technical support, I believe there's justification for the price difference."
"The pricing is the best part of this solution. It is free if you buy Umbrella or Duo Security. It is also a good solution."
"It would be nice if they had a different pricing model. Most of our budget for projects goes towards Cisco."
"The product is absolutely free to any customer. As such, the only thing one must keep in mind is that as long as he already has one Cisco security product, irregardless of what that product is, SecureX is available for free."
"You can spend less money for another solution, but if you really want to have a good solution you have to pay. We are happy that we are getting such a good solution for what we are spending."
"For the value you get, the pricing of the solution is excellent."
"It comes free with all Cisco products. So, it is a good price."
"The pricing is competitive, especially for education institutions. Licensing can be a little bit difficult to navigate, especially with resellers with Cisco, but for us it has been pretty easy."
"Microsoft purposely makes its license combinations complex and includes combinations like Microsoft 365 E3 and Microsoft 365 E5, Office 365 E3, Office 365 E5, and Office 365 E1, so you get confused. Microsoft tries to sell you a bundle of a lot of things together."
"It has consistently offered highly appealing academic pricing, with distinct rates for higher education and general educational purposes."
"Microsoft should provide lower-level licensing options. They should do it in such a way that even an individual could purchase a license, and it should be entirely flexible."
"We have a lot of problems in Latin America regarding the price of Microsoft 365 Defender, because the relationship between dollars and the money of the different countries, it's is a lot. Many customers that have small businesses say that they would like the solution but it is too expensive. However, large companies do not find the cost an issue."
"With the little idea I have about the costs, I can say that XDR tools tend to be a bit expensive. If you are using Microsoft Defender XDR, then you need to go for a subscription-based pricing model."
"The pricing of Microsoft 365 Defender is definitely on the costly side, but with the features and services that Microsoft provides, such as the seamless integration of all the Defender tools, while the price is on the higher side, there is no alternative."
"They have moved from a licensing model to pay-per-use... The question is: What happens if, for any reason, there's not enough budget to accept this model? That could be a great problem."
"Microsoft Defender XDR is expensive."
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Top Industries

By visitors reading reviews
Outsourcing Company
12%
Comms Service Provider
12%
Construction Company
11%
Financial Services Firm
9%
Outsourcing Company
24%
Construction Company
14%
Marketing Services Firm
8%
Comms Service Provider
6%
Financial Services Firm
9%
Computer Software Company
8%
Outsourcing Company
8%
Comms Service Provider
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business47
Midsize Enterprise21
Large Enterprise55
By reviewers
Company SizeCount
Small Business4
Midsize Enterprise7
Large Enterprise3
By reviewers
Company SizeCount
Small Business46
Midsize Enterprise28
Large Enterprise41
 

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Also Known As

Cyvera, Cortex XDR, Palo Alto Networks Traps
Kenna.AppSec, Kenna.VI
Microsoft 365 Defender, Microsoft Threat Protection, MS 365 Defender
 

Overview

 

Sample Customers

CBI Health Group, University Honda, VakifBank
NHS, Rackspace, UNC Pembroke, University of North Carolina at Charlotte, Missing Piece
Accenture, Deloitte, ExxonMobil, General Electric, IBM, Johnson & Johnson and many others.
Find out what your peers are saying about SentinelOne, TrendAI, Wazuh and others in Extended Detection and Response (XDR). Updated: September 2026.
913,924 professionals have used our research since 2012.