We're a local government entity and also a very Microsoft-centric shop. We use it for backing up the following workload types (All servers running Windows Server 20xx): 
- Physical Windows Servers
- Hyper-V Servers (at the host level)
- Hyper-V Servers ( at the guest level)
- Sharepoint
- Exchange 
- Network File Shares, implemented as CAFS (Continuously Available File Shares)

The most important use case is in the recovery of some data.

We can recover after users or bad applications have deleted data.

Sometimes we use it for recovery, the complete recovery of machines.

We primarily use the solution as a backup. We have some standalone and beta on it, however, we haven't got the whole stack on it now.

We are using this product for backing up our entire environment, which includes our ERP and all of the other systems that we have.

My work is on the customer side. I analyze a company's situation and figure out what's best for them from a cost perspective and an installation perspective. I'm a customer of Microsoft and managing director of the company. 

This solution is part of our main disaster recovery as well as long term recovery solution policy. It will work on physical and virtual machines.