We have 1500 users and even with a reasonable sized support team we find SCCM difficult to manage. I haven't experienced the other solutions, but I suspect you will be better placed with an alternative to SCCM.
Having previously run a penetration testing company, I can tell you that the general feedback I have from professional hackers is that CrowdStrike Falcon does make their job a lot more difficult.
The "traditional" players in the endpoint protection market e.g. Trend Micro…